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| 1 | An epidermal sEMG tattoo-like patch as a new human–machine interface for patients with loss of voice显示文摘Throat cancer treatment involves surgical removal of the tumor,leaving patients with facial disfigurement as well as temporary or permanent loss of voice.Surface electromyography(sEMG)generated from the jaw contains lots of voice information.However,it is difficult to record because of not only the weakness of the signals but also the steep skin curvature.This paper demonstrates the design of an imperceptible,flexible epidermal sEMG tattoo-like patch with the thickness of less than 10μm and peeling strength of larger than 1N cm−1 that exhibits large adhesiveness to complex biological surfaces and is thus capable of sEMG recording for silent speech recognition.When a tester speaks silently,the patch shows excellent performance in recording the sEMG signals from three muscle channels and recognizing those frequently used instructions with high accuracy by using the wavelet decomposition and pattern recognization.The average accuracy of action instructions can reach up to 89.04%,and the average accuracy of emotion instructions is as high as 92.33%.To demonstrate the functionality of tattoo-like patches as a new human–machine interface(HMI)for patients with loss of voice,the intelligent silent speech recognition,voice synthesis,and virtual interaction have been implemented,which are of great importance in helping these patients communicate with people and make life more enjoyable. | Huicong Liu Wei Dong Yunfei Li Fanqi Li Jiangjun Geng Minglu Zhu Tao Chen Hongmiao Zhang Lining Sun Chengkuo Lee | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 2 | Characterization of bacterial community dynamics in a full-scale drinking water treatment plant显示文摘Understanding the spatial and temporal dynamics of microbial communities in drinking water systems is vital to securing the microbial safety of drinking water.The objective of this study was to comprehensively characterize the dynamics of microbial biomass and bacterial communities at each step of a full-scale drinking water treatment plant in Beijing,China.Both bulk water and biofilm samples on granular activated carbon(GAC) were collected over 9 months.The proportion of cultivable cells decreased during the treatment processes,and this proportion was higher in warm season than cool season,suggesting that treatment processes and water temperature probably had considerable impact on the R2 A cultivability of total bacteria.16 s rRNA gene based 454 pyrosequencing analysis of the bacterial community revealed that Proteobacteria predominated in all samples.The GAC biofilm harbored a distinct population with a much higher relative abundance of Acidobactena than water samples.Principle coordinate analysis and one-way analysis of similarity indicated that the dynamics of the microbial communities in bulk water and biofilm samples were better explained by the treatment processes rather than by sampling time,and distinctive changes of the microbial communities in water occurred after GAC filtration.Furthermore,20 distinct OTUs contributing most to the dissimilarity among samples of different sampling locations and 6 persistent OTUs present in the entire treatment process flow were identified.Overall,our findings demonstrate the significant effects that treatment processes have on the microbial biomass and community fluctuation and provide implications for further targeted investigation on particular bacteria populations. | Cuiping Li Fangqiong Ling Minglu Zhang Wen-Tso Liu Yuxian Li Wenjun Liu | 2017 | Journal of Environmental Sciences2017，29，1： | 5 |
| 3 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 4 | Parametric analysis of mechanical behavior of steel planer tubular truss under fire 显示文摘 | Jin Meng Zhao Jincheng Liu Minglu | 2011 | Journal of Constructional Steel Research2011，67，1： | 1 |
| 5 | Study on coordinated control and hardware system of a mobile manipulator显示文摘 | Yingshu Chen Libing Liu Minglu Zhang ect | 2006 | Proceedings of the 6th world congress on intelligent control and automation2006，，6： | 1 |
| 6 | An experiment study of the mechanical behavior of steel planar trusses in a fire 显示文摘 | Liu Minglu Zhao Jincheng Jin Meng | 2010 | Journal of Constructional Steel Research2010，66，4： | 1 |
| 7 | Comparison of NOM removal and microbial properties in up-flow/down-flow BAC filter显示文摘 | Lineng Han Wenjun Liu Mo Chen Minglu Zhang Shuming Liu Ruilin Sun Xiangqin Fei | 2013 | Water Research2013，，： | 1 |
| 8 | Molecular analysis of bacteria/communities in biofilms of a drinking water clearwell 显示文摘 | ZHANG Minglu LIU Wenjun NIE Xuebiao | 2012 | Microbes and Environments2012，27，4： | 1 |
| 9 | Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model显示文摘CD4^(+)T cells are essential for sustaining CD8^(+)T cell responses during a chronic infection.The adoptive transfer of virus-specific CD4^(+)T cells has been shown to efficiently rescue exhausted CD8^(+)T cells.However,the question of whether endogenous virus-specific CD4^(+)T cell responses can be enhanced by certain vaccination strategies and subsequently reinvigorate exhausted CD8^(+)T cells remains unexplored.In this study,we developed a CD4^(+)T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus(LCMV)infection.We primed chronically LCMV-infected mice with a Listeria monocytogenes vector that expressed the LCMV glycoprotein-specific I-Ab-restricted CD4^(+)T cell epitope GP61–80(LM-GP61)and subsequently boosted the primed mice with an influenza virus A(PR8 strain)vector that expressed the same CD4^(+)T cell epitope(IAV-GP61).This heterologous prime-boost vaccination strategy elicited strong anti-viral CD4^(+)T cell responses,which further improved both the quantity and quality of the virusspecific CD8^(+)T cells and led to better control of the viral loads.The combination of this strategy and the blockade of the programmed cell death-1(PD-1)inhibitory pathway further enhanced the anti-viral CD8^(+)T cell responses and viral clearance.Thus,a heterologous prime-boost immunization that selectively induces virus-specific CD4^(+)T cell responses in conjunction with blockade of the inhibitory pathway may represent a promising therapeutic approach to treating patients with chronic viral infections. | Ran He Xinxin Yang Cheng Liu Xiangyu Chen Lin Wang Minglu Xiao Jianqiang Ye Yuzhang Wu Lilin Ye | 2018 | Cellular & Molecular Immunology2018，15，9： | 1 |
| 10 | POVA:traffic light sensing with probe vehicles显示文摘 | Zhu Yanmin Liu Xuemei Li Minglu | 2013 | IEEE Trans on Parallel and Distributed Systems2013，24，7： | 1 |
| 11 | Endotoxin contamination and control in surface water sources and a drinking water treatment plant in Beijing, China显示文摘 | Zhang Can Liu Wenjun Sun Wen Zhang Minglu Qian Lingjia Li Cuiping Tian Fang | 2013 | Water Research2013，，11： | 1 |
| 12 | Parametric analysis of mechanical behavior of steel planar tubular truss under fire显示文摘 | Meng Jin Jincheng Zhao Minglu Liu | | 0，，01： | 1 |
| 13 | Design and characterization of plasticized bacterial cellulose/waterborne polyurethane composite with antibacterial function for nasal stenting显示文摘A nasal stent capable of preventing adhesions and inflammation is of great value in treating nasal diseases.In order to solve the problems of tissue adhesion and inflammation response,we prepared plasticized bacterial cellulose(BCG)and waterborne polyurethane(WPU)composite with antibacterial function used as a novel nasal stent.The gelation behavior of BCG could contribute to protecting the paranasal sinus mucosa;meanwhile,the WPU with improved mechanical property was aimed at supporting the narrow nasal cavity.The thickness,size and the supporting force of the nasal stent could be adjusted according to the specific conditions of the nasal.Thermogravimetric analysis,contact angle and water absorption test were applied to investigate the thermal,hydrophilic and water absorption properties of the composite materials.The composite materials loaded with poly(hexamethylene biguanide)hydrochloride maintained well antibacterial activity over 12days.Animal experiments further revealed that the mucosal epithelium mucosae damage of BCG-WPU composite was minor compared with that of WPU.This new type of drug-loaded nasal stent can effectively address the postoperative adhesions and infections while ensuring the health of nasal mucosal,and thus has an immense clinical application prospects in treating nasal diseases. | Zhaoxuan Feng Minglu Li Xing Jin Yudong Zheng Junxiu Liu Liang Zhao Yansen Wang Hao Li Danlin Zuo | 2020 | Regenerative Biomaterials2020，7，6： | 1 |
| 14 | An In-VM Measuring Framework for Increasing Virtual Machine Security in Clouds显示文摘 | Liu Qian Weng Chuliang Li Minglu | 2010 | IEEE Transactions on Security&Privacy2010，8，6： | 1 |
| 15 | A Mandatory Access Control Framework in Virtual Machine System with Respect to Multi-level Security I: Theory显示文摘At present,there are few security models which control the communication between virtual machines (VMs).Moreover,these models are not applicable to multi-level security (MLS).In order to implement mandatory access control (MAC) and MLS in virtual machine system,this paper designs Virt-BLP model,which is based on BLP model.For the distinction between virtual machine system and non-virtualized system,we build elements and security axioms of Virt-BLP model by modifying those of BLP.Moreover,comparing with BLP,the number of state transition rules of Virt-BLP is reduced accordingly and some rules can only be enforced by trusted subject.As a result,Virt-BLP model supports MAC and partial discretionary access control (DAC),well satisfying the requirement of MLS in virtual machine system.As space is limited,the implementation of our MAC framework will be shown in a continuation. | LIU Qian WANG Guanhai WENG Chuliang LUO Yuan LI Minglu | 2010 | China Communications2010，7，4： | 1 |
| 16 | Single-cell RNA Sequencing Reveals Sexually Dimorphic Transcriptome and Type 2 Diabetes Genes in Mouse Islet β Cells显示文摘Type 2 diabetes(T2D)is characterized by the malfunction of pancreaticβcells.Susceptibility and pathogenesis of T2D can be affected by multiple factors,including sex differences.However,the mechanisms underlying sex differences in T2D susceptibility and pathogenesis remain unclear.Using single-cell RNA sequencing(scRNA-seq),we demonstrate the presence of sexually dimorphic transcriptomes in mouseβcells.Using a high-fat diet-induced T2D mouse model,we identified sex-dependent T2D altered genes,suggesting sex-based differences in the pathological mechanisms of T2D.Furthermore,based on islet transplantation experiments,we found that compared to mice with sexmatched islet transplants,sex-mismatched islet transplants in healthy mice showed down-regulation of genes involved in the longevity regulating pathway ofβcells.Moreover,the diabetic mice with sex-mismatched islet transplants showed impaired glucose tolerance.These data suggest sexual dimorphism in T2D pathogenicity,indicating that sex should be considered when treating T2D.We hope that our findings could provide new insights for the development of precision medicine in T2D. | Gang Liu Yana Li Tengjiao Zhang Mushan Li Sheng Li Qing He Shuxin Liu Minglu Xu Tinghui Xiao Zhen Shao Weiyang Shi Weida Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 1 |
| 17 | Research and Development of Ceramic Filtration Membrane显示文摘Ceramic filter membrane plays an irreplaceable role in many fields because of its unique advantages. However, the complicated preparation process and high cost still limit the large scale application of ceramic fi lter membrane. Therefore, to improve the preparation process of ceramic fi lter membrane, optimize the membrane system structure is the ceramic fi lter membrane industry is facing major problems. In this paper, the structure, separation principle, preparation technology and application of ceramic fi lter membrane are introduced. | Minglu Deng Rong Chen Sirong Liu | 2018 | Ceramic Sciences and Engineering2018，1，1： | 1 |
| 18 | A Novel Goodness of Fit Test Spectrum Sensing Using Extreme Eigenvalues显示文摘The existing Goodness of fit(GoF)test based spectrum sensing algorithms mostly use samples or energies as observations to make decisions,which can hardly achieve satisfactory performance especially when the Primary user(PU)signals are highly correlated.Meanwhile,the eigenvalue of covariance matrix can reflect signal correlations well.Motivated by this,we study the distribution of eigenvalue and propose an eigenvalue based GoF spectrum sensing algorithm.In the proposed scheme,we use the ratios of maximum to minimum eigenvalue as observations and thus it can bring performance improvements through capturing correlation of PU signals.We also provide the related theoretical analysis for the proposed method.Simulation results show that the proposed method overcomes the problem of noise uncertainty and achieves performance improvement over the classical samples-based GoF test. | LI He ZHAO Wenjing LIU Chang JIN Minglu YOO Sang-Jo | 2020 | Chinese Journal of Electronics2020，29，6： | 0 |
| 19 | Self-supported ultrathin NiCo layered double hydroxides nanosheets electrode for efficient electrosynthesis of formate显示文摘Electrochemical CO_(2)reduction into energy-carrying compounds,such as formate,is of great importance for carbon neutrality,which however suffers from high electrical energy input and liquid products crossover.Herein,we fabricated self-supported ultrathin NiCo layered double hydroxides(LDHs)electrodes as anode for methanol electrooxidation to achieve a high formate production rate(5.89 mmol h^(-1)cm^(-2))coupled with CO_(2)electro-reduction at the cathode.A total formate faradic efficiency of both anode for methanol oxidation and cathode for CO_(2)reduction can reach up to 188%driven by a low cell potential of only 2.06 V at 100 mA cm^(-2)in membrane-electrode assembly(MEA).Physical characterizations demonstrated that Ni^(3+)species,formed on the electrochemical oxidation of Ni-containing hydroxide,acted as catalytically active species for the oxidation of methanol to formate.Furthermore,DFT calculations revealed that ultrathin LDHs were beneficial for the formation of Ni^(3+)in hydroxides and introducing oxygen vacancy in NiCo-LDH could decrease the energy barrier of the rate-determining step for methanol oxidation.This work presents a promising approach for fabricating advanced electrodes towards electrocatalytic reactions. | Haoyuan Chi Jianlong Lin Siyu Kuang Minglu Li Hai Liu Qun Fan Tianxiang Yan Sheng Zhang Xinbin Ma | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 20 | Responses of microbial interactions to elevated salinity in activated sludge microbial community显示文摘Biological treatment processes are critical for sewage purification,wherein microbial interactions are tightly associated with treatment performance.Previous studies have focused on assessing how environmental factors(such as salinity)affect the diversity and composition of the microbial community but ignore the connections among microorganisms.Here,we described the microbial interactions in response to elevated salinity in an activated sludge system by performing an association network analysis.It was found that higher salinity resulted in low microbial diversity,and small,complex,more competitive overall networks,leading to poor performance of the treatment process.Subnetworks of major phyla(Proteobacteria,Bacteroidetes,and Chloroflexi)and functional bacteria(such as AOB,NOB and denitrifiers)differed substantially under elevated salinity process.Compared with subnetworks of Nitrosomonadaceae,Nitrosomonas(AOB)made a greater contribution to nitrification under higher salinity(especially 3%)in the activated sludge system.Denitrifiers established more proportion of cooperative relationships with other bacteria to resist 3%salinity stress.Furthermore,identified keystone species playing crucial roles in maintaining process stability were dynamics and less abundant under salinity disturbance.Knowledge gleaned from this study deepened our understanding of microbial interaction in response to elevated salinity in activated sludge systems. | Tao Ya Zhimin Wang Junyu Liu Minglu Zhang Lili Zhang Xiaojing Liu Yuan Li Xiaohui Wang | 2023 | Frontiers of Environmental Science & Engineering2023，17，5： | 0 |
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