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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | 人工全膝关节置换术后单纯金属底座髌骨假体的翻修显示文摘目的分析带金属底座髌骨假体失败的原因,并观察单纯髌骨假体翻修的临床疗效。方法对 22例 (30膝 )人工全膝关节置换术后因金属底座髌骨假体失败而行单纯髌骨假体翻修者进行回顾性分析。假体均为同一类型的后十字韧带保留型假体,以金属底座髌骨假体置换髌骨。应用膝关节 KSS评分标准评价翻修术后的临床转归。结果髌骨假体失败时间在人工全膝关节置换术后的 26~ 96个月,平均 62.3个月,主要症状有金属摩擦感 (80% )和膝关节疼痛 (70% )。术中发现 23膝 (76.7% )聚乙烯完全磨损、金属底座外露; 9膝髌骨倾斜或半脱位; 2膝完全脱位。 30膝均成功施行骨水泥全聚乙烯髌骨翻修术,随访时间 24~ 81个月,平均 42.5个月。所有患者主诉症状消失,可独立行走活动,膝关节评分从术前的平均 73分( 27~ 88分)增加至 87分( 60~ 100分);膝关节屈曲度由术前的平均 91°增加至 99.5°。结论 (1)金属底座髌骨假体早期失败率较高; (2)髌骨位线不良和异常滑动轨迹是导致带金属底座髌骨假体失败的诱发因素; (3)单纯髌骨假体翻修可获满意的临床结果,其发生并发症的潜在危险和人工全膝关节翻修术相似,应予以重视。 | 张先龙 SJ Yue NN Lo KH Seow SK Tan | 2001 | 中华骨科杂志2001，21，1： | 2 |
| 3 | Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen显示文摘 | Wang YM NG WC LO SK | 1999 | J Gastroenterol1999，34，5： | 1 |
| 4 | Adverse metabolic and microbiological effects of tube feeding in experimental canine obstructive jaundice显示文摘 | Chuang JH Chen WJ Lo SK | 1997 | JPEN1997，21，1： | 1 |
| 5 | Duodenal histology in patients with celiac disease after trealment with a gluten-free diet显示文摘 | Lee SK Lo W Memeto L | 2003 | Gastrointest Endosc :2003，57，2： | 1 |
| 6 | The clinical utility of wireless capsule endoscopy显示文摘 | Arnott ID Lo SK | 2004 | Digestive Disease and Sciences2004，49，6： | 1 |
| 7 | Factors associated with poo- rly controlled hypertension in continuous ambulatory peritone- al dialysis patients 显示文摘 | Wong PN Mak SK Lo KY | 2004 | Singapore Med J2004，45，11： | 1 |
| 8 | Vascular endothelial adhesion molecules and tissue inflammation显示文摘 | Malik AB Lo SK | 1996 | Pharmacol Rev1996，48，2： | 1 |
| 9 | Molecular cloning of the human fertilin 3 subunit 显示文摘 | Gupta SK Alves K Palladino LO | 1996 | Biochem Biophys Res Commun1996，224，2： | 1 |
| 10 | Gonadoblastoma in patient with Tumer's syndrome 显示文摘 | Lo KW Lam SK Cheung TH | 1996 | J Obstet Gynaecol1996，22，： | 1 |
| 11 | Neutrophil-activating protein interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils显示文摘 | Lo SK Olsenbert Egber E | 2001 | J Exp Med2001，171，10： | 1 |
| 12 | Endoscopic management of pancreatic pseudocysts显示文摘 | Lo SK Rowe A | 1977 | Gastroenterologist1977，5，： | 1 |
| 13 | Antiphospholipid antibodies activate vascular endothelial cells显示文摘 | Simantov R Lo SK Gharavi A | 1996 | Lupus1996，5，： | 1 |
| 14 | Papillary endolyohamic sac tumors:CT,MR imaging,and angiographic Findings in 20 patients显示文摘 | Mukherji SK Albernaz VS Lo WW | 1997 | Radiology1997，202，3： | 1 |
| 15 | Prevalence of and risk factors for erectile dysfunction in Hong Kong diabetic patients 显示文摘 | Siu SC Lo SK Wong KW | 2001 | Diabet Med2001，18，9： | 1 |
| 16 | Role of platelets in maintenance of pulmonary vascular permeability to protein 显示文摘 | Lo SK Burhop KE Kaplan JE | 1988 | Am J Physiol1988，254，： | 1 |
| 17 | Predicting the grade of disability lyear after stroke following rehabihtation 显示文摘 | Lin JH Tsai AY Lo SK | 2005 | Kaohsiung J Med Sci2005，21，： | 1 |
| 18 | Initial experience with wireless cap- sule enteroscopy in the diagnosis and management of inflammatory bow- el disease 显示文摘 | Mow WS Lo SK Targan SR | 2004 | Clin Gastroenterol Hepatol2004，2，： | 1 |
| 19 | Prevalence of anti-neutrophil antibody in primary sclerosing cholangitis and ulcerative colitis using an alkaline phosphatase technique 显示文摘 | Fleming KA Chapman RW | 1992 | Gut1992，33，10： | 1 |
| 20 | In vivo expression of neutrophil inhibitory factor via gene transfer prevents lipopolysaccharide-induced lung neutrophil infiltration and injury by a beta2 integrin-dependent mechanism显示文摘 | Zhou MY Lo SK Magnus B | 1998 | J Clin Invest1998，101，： | 1 |
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