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| 1 | Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi. | Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 80 |
| 2 | Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines显示文摘AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H.pylori Sydney strain 1 was performed with broth dilution method.Anti-H.pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS:The water extract from Rhizoma Coptidis,Radix Scutellariae and Radix isatidis could significantly inhibit the H.pylori activity with their MIC less than 7.8 mg/mL,suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H.pylori infection.CONCLUSION:Rhizoma Coptidis,Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H.pylori. | Feng Ma Ye Chen Jing Li He-Ping Qing Ji-De Wang YaLi Zhang Yang Bai Bei-Guo Long | 2010 | World Journal of Gastroenterology2010，16，44： | 34 |
| 3 | Relationship between expression of α-fetoprotein messenger RNA and some clinical parameters of human hepatocelular carcinoma显示文摘METHODWedetectedtheexpressionofAFPinmRNAlevelintissuesamplesfrom52patientssuferingfromHCCbyRTPCRmethod.RESULTSThepositiverat... | HE Ping, TANG Zhao You, YE Sheng Long and LIU Bin Bin | 1999 | World Journal of Gastroenterology1999，5，2： | 23 |
| 4 | Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing. | JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU | 2017 | Photonics Research2017，5，4： | 20 |
| 5 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 6 | Magnetogenetics: remote non-invasive magnetic activation of neuronal activity with a magnetoreceptor显示文摘Current neuromodulation techniques such as optogenetics and deep-brain stimulation are transforming basic and translational neuroscience. These two neuromodulation approaches are, however, invasive since surgical implantation of an optical fiber or wire electrode is required. Here, we have invented a non-invasive magnetogenetics that combines the genetic targeting of a magnetoreceptor with remote magnetic stimulation. The noninvasive activation of neurons was achieved by neuronal expression of an exogenous magnetoreceptor, an iron-sulfur cluster assembly protein 1(Isca1). In HEK-293 cells and cultured hippocampal neurons expressing this magnetoreceptor, application of an external magnetic field resulted in membrane depolarization and calcium influx in a reproducible and reversible manner, as indicated by the ultrasensitive fluorescent calcium indicator GCa MP6 s.Moreover, the magnetogenetic control of neuronal activity might be dependent on the direction of the magnetic field and exhibits on-response and off-response patterns for the external magnetic field applied. The activation of this magnetoreceptor can depolarize neurons and elicit trains of action potentials, which can be triggered repetitively with a remote magnetic field in whole-cell patch-clamp recording.In transgenic Caenorhabditis elegans expressing this magnetoreceptor in myo-3-specific muscle cells or mec-4-specific neurons, application of the external magnetic field triggered muscle contraction and withdrawal behavior of the worms, indicative of magnet-dependent activation of muscle cells and touch receptor neurons, respectively. The advantages of magnetogenetics over optogenetics are its exclusive non-invasive, deep penetration, long-term continuous dosing, unlimited accessibility, spatial uniformity and relative safety. Like optogenetics that has gone through decade-long improvements, magnetogenetics, with continuous modification and maturation, will reshape the current landscape of neuromodulation toolboxes and will have a broad range of applications to basic and translational neuroscience as well as other biological sciences. We envision a new age of magnetogenetics is coming. | Xiaoyang Long Jing Ye Di Zhao Sheng-Jia Zhang | 2015 | Science Bulletin2015，60，24： | 19 |
| 7 | Nuclear factor kappa B: A marker of chemotherapy for human stage Ⅳ gastric carcinoma显示文摘AIM: To detect the nuclear factor kappa B (NF-κB) condition in human stage Ⅳ gastric carcinoma patients and to explore the correlation between NF- κB activation and survival of these patients after chemotherapy. METHODS: Expression of NF-κB-p65 was determined by immunohistochemical analysis. Activity of NF- κB DNA-binding in carcinoma tissue was detected by electrophoretic mobility shift assay. Kaplan-Meier survival analysis was performed to show the relation between NF-κB and progression-free survival (PFS) or overall survival (OS) of the patients. RESULTS: The positive expression rate of NF-κB-p65 in 60 gastric cancer tissue samples was 76.7% (46/60). The expression of NF-κB-p65 was reduced in adjacent carcinoma and normal tissue samples. Electrophoretic mobility shift assay (EMSA) analysis showed a strong activation of NF-κB in cancer tissue samples. A survival difference was found in NF- κB-p65 positive and negative patients. NF-κB-p65 expression was negative in cancer tissue samples (n = 14). PFS was 191.40 ± 59.88 d and 152.93 ± 16.99 d, respectively, in patients with positive NF- κB-p65 expression (n = 46) (P = 0.4028). Thesurvival time of patients with negative and positive NF-κB-p65 expression was 425.16 ± 61.61 d and 418.85 ± 42.98 d, respectively (P = 0.7303). Kaplan-Meier analysis showed no significant difference in PFS or OS. The 46 patient tissue which positive NF- κB-p65 expression was found in the tissue samples from the 46 patients whose PFS and OS were 564.89 ± 75.94 d and s 352.37 ± 41.32 d, respectively (P = 0.0165). CONCLUSION: NF-κB is activated in gastric carcinoma tissue, which is related to the OS after chemotherapy. | Sheng Ye You-Ming Long Jian Rong Wen-Rui Xie | 2008 | World Journal of Gastroenterology2008，14，30： | 18 |
| 8 | Prognostic factors and survival in patients with gastric stump cancer显示文摘AIM:To elucidate the clinicopathological characteristics and prognostic factors of gastric stump cancer(GSC).METHODS:The clinical data for 92 patients with GSC were collected at Fudan University Shanghai Cancer Center.The prognostic factors were analyzed with Cox proportional hazard models.RESULTS:GSC tended to occur within 25 years following the primary surgery,when the initial disease is benign,whereas it primarily occurred within the first15 years post-operation for gastric cancer.Patients with regular follow-up after primary surgery had a better survival rate.The multivariate Cox regression analysis revealed that Borrmann type?Ⅰ/Ⅱ(HR=3.165,95%CI:1.055-9.500,P=0.040)and radical resection(HR=1.780,95%CI:1.061-2.987,P=0.029)were independent prognostic factors for GSC.The overall 1-,3-,and 5-year survival rates of the 92 patients were78.3%,45.6%and 27.6%,respectively.The 1-,3-,and 5-year survival rates of those undergoing radical resection were 79.3%,52.2%,and 37.8%,respectively.The 5-year survival rates for stages?Ⅰ,Ⅱ,Ⅲ,andⅣwere 85.7%,47.4%,16.0%,and 13.3%,respectively(P=0.005).CONCLUSION:The appearance of GSC occurs sooner in patients with primary malignant cancer than in patients with a primary benign disease.Therefore,close follow-up is necessary.The overall survival of patients with GSC is poor,and curative resection can improve their prognosis. | Hua Huang Wei Wang Zhong Chen Jie-Jie Jin Zi-Wen Long Hong Cai Xiao-Wen Liu Ye Zhou Ya-Nong Wang | 2015 | World Journal of Gastroenterology2015，21，6： | 16 |
| 9 | Epidermal growth factor receptor antibody plus recombinant human endostatin in treatment of hepatic metastases after remnant gastric cancer resection显示文摘We report a 55-year-old male who developed advanced hepatic metastasis and peritoneal carcinomatosis after resection of remnant gastric cancer resection 3 mo ago. The patient only received epidermal growth factor (EGF) receptor antibody (Cetuximab) plus recombinant human endostatin (Endostar). Anti-tumor activity was assessed by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computer tomography (PET/CT) at baseline and then every 4 wk. The case illustrates that 18FDG-PET/CT could make an early prediction of the response to Cetuximab plus Endostar in such clinical situations. 18FDG-PET/CT is a useful molecular imaging modality to evaluate the biological response advanced hepatic metastasis and peritoneal carcinomatosis to Cetuximab plus Endostar in patients after remnant gastric cancer resection. | Long Sun Huang-Yang Ye Ying-Hong Zhang Yong-Song Guan Hua Wu | 2007 | World Journal of Gastroenterology2007，13，45： | 15 |
| 10 | Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells显示文摘AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie(XTSJ) decoction on gastric cancer stem-like cells(GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted by FACS using the cancer stem cell marker CD44; the stemness of these cells was checked in our previous study. In an in vitro study, the expression of Notch-1, Hes1, Vascular endothelial growth factor(VEGF), and Ki-67 in both CD44-positive gastric cancer stem-like cells(GCSCs) and CD44-negative cells was measured by Western blot. The effect of XTSJ serum on cell viability and on the above markers was measured by MTT assay and Western blot, respectively. In an in vivo study, the ability to induce angiogenesis and maintenance of GCSCs in CD44-positive-MKN-45- and CD44-negative-engrafted mice were detected by immunohistochemical staining using markers for CD34 and CD44, respectively. The role of XTSJ decoction in regulating the expression of Notch-1, Hes1, VEGF and Ki-67 was measured by Western blot and real-time polymerase chain reaction.RESULTS: CD44+ GCSCs showed more cell proliferation and VEGF secretion than CD44-negative cells in vitro, which were accompanied by the high expression of Notch-1 and Hes1 and positively associated with tumor growth(GCSCs vs CD44-negative cells, 2.72 ± 0.25 vs 1.46 ± 0.16, P < 0.05) and microvessel density(MVD)(GCSCs vs CD44-negative cells, 8.15 ± 0.42 vs 3.83 ± 0.49, P < 0.001) in vivo. XTSJ decoction inhibited the viability of both cell types in a dose-dependent manner in vitro. Specifically, a significant difference in the medium-(82.87% ± 6.53%) and high-dose XTSJ groups(77.43% ± 7.34%) was detected at 24 h in the CD44+ GCSCs group compared with the saline group(95.42% ± 5.76%) and the low-dose XTSJ group(90.74% ± 6.57%)(P < 0.05). However, the efficacy of XTSJ decoction was reduced in the CD44- groups; significant differences were only detected in the high-dose XTSJ group at 48 h(78.57% ± 6.94%) and 72 h(72.12% ± 7.68%) when compared with the other CD44- groups(P < 0.05). Notably, these differences were highly consistent with the Notch-1, Hes1, VEGF and Ki-67 expression in these cells. Similarly, in vivo, XTSJ decoction inhibited tumor growth in a dose-dependent manner. A significant difference was observed in the medium(1.76 ± 0.15) and high-dose XTSJ(1.33 ± 0.081) groups compared with the GCSCs control group(2.72 ± 0.25) and the low-dose XTSJ group(2.51 ± 0.25)(P < 0.05). We also detected a remarkable decrease of MVD in the medium-(7.10 ± 0.60) and high-dose XTSJ(5.99 ± 0.47) groups compared with the GCSC control group(8.15 ± 0.42) and the low-dose XTSJ group(8.14 ± 0.46)(P < 0.05). Additionally, CD44 expression was decreased in these groups [medium-(4.43 ± 0.45) and high-dose XTSJ groups(3.56 ± 0.31) vs the GCSC control(5.96 ± 0.46) and low dose XTSJ groups(5.91 ± 0.38)](P < 0.05). The significant differences in Notch-1, Hes1, VEGF and Ki-67 expression highly mirrored the results of XTSJ decoction in inhibiting tumor growth, MVD and CD44 expression.CONCLUSION: Notch-1 may play an important role in regulating the proliferation of GCSCs; XTSJ decoction could attenuate tumor angiogenesis, at least partially, by inhibiting Notch-1. | Bing Yan Long Liu Ying Zhao Li-Juan Xiu Da-Zhi Sun Xuan Liu Ye Lu Jun Shi Yin-Cheng Zhang Yong-Jin Li Xiao-Wei Wang Yu-Qi Zhou Shou-Han Feng Can Lv Pin-Kang Wei Zhi-Feng Qin | 2014 | World Journal of Gastroenterology2014，20，36： | 14 |
| 11 | Circulating Dickkopf-1 and osteoprotegerin in patients with early and longstanding rheumatoid arthritis显示文摘背景风湿性关节炎(RA ) 被 synovial 膜的发炎描绘,导致进有象后果的关节的软骨和骨头的降级的邻近的软骨矩阵的 synovial 织物的侵略。Dickkopf-1 (DKK-1 ) 和 osteoprotegerin (OPG ) 被表明了是涉及改变的骨头侵蚀和骨头的关键分子。这研究的目的是在蛋白质 DKK-1 铺平的 RA.Methods 的不同舞台探索 DKK-1 和 OPG 的潜在的角色, OPG 被 ELISA 检测。浆液样品与 RA 和 60 健康控制从 300 个病人被收集。哪个, 150 个 RA 病人被定义为早 RA (疾病持续时间 1 年) ,和另外的 150 RA 病人们被定义为 longlasting RA (疾病持续时间 5 年) 。在浆液采样的时候,各种各样临床并且实验室参数被估计。 DKK-1 或 OPG 和 clinical/laboratory 参数的关联是 analyzed.Results 当没有重要差别在 OPG.In 对比的水平在二个组之间被观察时, DKK-1 的浆液水平与健康控制相比与长期的 RA 在病人被提高,在早 RA 病人,传播 OPG 被提高,当在 DKK-1 的表示的二个组之间没有重要差别时。浆液 DKK-1 在长期的 RA 病人与锋利的分数和 DAS28 被相关。在早 RA,年龄是是的唯一的参数显著地与在那里的浆液 OPG.Conclusions 有关是在 DKK-1 和 OPG 之间的串音,它在 RA 在骨头破坏包含了。在 RA 的不同舞台, DKK-1 和 OPG 可以在 RA 的致病起不同作用。 | LIU Yan-ying LONG Li WANG Shi-yao GUO Jian-ping YE Hua CUI Liu-fu YUAN Guo-hua LI Zhan-guo | 2010 | Chinese Medical Journal2010，，11： | 14 |
| 12 | Enhanced photocatalytic activity of rGO/TiO2 for the decomposition of formaldehyde under visible light irradiation显示文摘Due to the low concentration of indoor air contaminants,photocatalytic technology shows low efficiency for indoor air purification.The application of TiO_2 for photocatalytic removal of formaldehyde is limited,because TiO_2 can only absorb ultraviolet(UV) light.Immobilization of TiO_2 nanoparticles on the surface of graphene can improve the visible light photocatalytic activity and the adsorption capacity.In this study,rGO(reduced graphene oxide)/TiO_2 was synthesized through a hydrothermal method using titanium tetrabutoxide and graphene oxide as precursors,and was used for the degradation of low concentration formaldehyde in indoor air under visible light illumination.Characterization of the crystalline structure and morphology of rGO/TiO_2 revealed that most GO was reduced to rGO during the hydrothermal treatment,and anatase TiO_2 nanoparticles(with particle size of 15–30 nm) were dispersed well on the surface of the rGO sheets.rGO/TiO_2 exhibited excellent photocatalytic activity for degradation of formaldehyde in indoor air and this can be attributed to the role of rGO,which can act as the electron sink and transporter for separating photo-generated electron–hole pairs through interfacial charge transfer.Furthermore,rGO could adsorb formaldehyde molecules from air to produce a high concentration of formaldehyde on the surface of rGO/TiO_2.Under visible light irradiation for 240 min,the concentration of formaldehyde could be reduced to 58.5 ppbV.rGO/TiO_2 showed excellent moisture-resistance behavior,and after five cycles,r GO/TiO_2 maintained high photocatalytic activity for the removal of formaldehyde(84.6%).This work suggests that the synthesized rGO/TiO_2 is a promising photocatalyst for indoor formaldehyde removal. | Lian Yu Long Wang Xibo Sun Daiqi Ye | 2018 | Journal of Environmental Sciences2018，30，11： | 13 |
| 13 | Ginsenoside-Rg_6, a Novel Triterpenoid Saponin from the Stem-Leaves of Panax ginseng C. A. Mey.显示文摘A novel dammarane-type triterpene oligoglycoside, named ginsenoside-Rg6 3, was isolated from the stem-leaves of Panax ginseng C. A. Mey., together with two known ones, 20(S)-ginsenoside-Rg2 1 and 20(R)-ginsenoside-Rg2 2. On the basis of chemical and physicochemical evidence , the structure of ginsenoside-Rg6 have been elucidated as 6-O-(-L-rhamnosyl-(1?2)-(-D-glucopyranosyl-dammarane-(E)-20(22), 24-diene-3(, 6(, 12(-triol. | Xiu Wei YANG, Long Yun LI, Jian Ming TIAN, Zhi Wei ZHANG, Jin Mei YE, Wei Fang Gu (National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083) (Academy of Chinese Traditional Medicine and Materia Medica of Jilin Provinc | 2000 | Chinese Chemical Letters2000，11，10： | 12 |
| 14 | Realizing over 10% efficiency in polymer solar cell by device optimization显示文摘The low band gap polymer based on benzodithiophene(BDT)-thieno[3,4-b]thiophene(TT)backbone,PBDT-TS1,was synthesized following our previous work and the bulk heterojunction(BHJ)material comprising PBDT-TS1/PC71BM was optimized and characterized.By processing the active layer with different additives i.e.1,8-diiodooctane(DIO),1-chloronaphthalene(CN)and 1,8-octanedithiol(ODT)and optimizing the ratio of each additive in the host solvent,a high PCE of 9.98%was obtained under the condition of utilizing 3%DIO as processing additive in CB.The effect of varied additives on photovoltaic performance was illustrated with atomic force microscopy(AFM)and transmission electron microscope(TEM)measurements that explained changes in photovoltaic parameters.These results provide valuable information of solvent additive choice in device optimization of PBDTTT polymers,and the systematic device optimization could be applied in other efficient photovoltaic polymers.Apparently,this work presents a great advance in single junction PSCs,especially in PSCs with conventional architecture. | Shaoqing Zhang Long Ye Wenchao Zhao Bei Yang Qi Wang Jianhui Hou | 2015 | Science China Chemistry2015，58，2： | 12 |
| 15 | Fixation of CO_2 by electrocatalytic reduction to synthesis of dimethyl carbonate in ionic liquid using effective silver-coated nanoporous copper composites显示文摘与高表面区域,开的孔和高效率,催化剂在 electrocatalytic 被准备并且第一采用了 CO2 的减小和 dimethyl 碳酸盐(直接数字控制) 的 electrosynthesis。为在离子的液体的 CO2 的 electrocatalytic 减小的电气化学的性质被周期的 voltammogram (CV ) 学习。象 electrocatalytic 性能上的温度,工作潜力和阴极材料一样的各种各样的反应变量的效果也被调查。直接数字控制的 80% 产量在最佳的反应条件下面被获得。 | Xuan Yun Wang Su Qin Liu Ke Long Huang Qiu Ju Feng De Lai Ye Bing Liu Jin Long Liu Guan Hua Jin | 2010 | Chinese Chemical Letters2010，21，8： | 10 |
| 16 | Adsorption of VOCs on reduced graphene oxide显示文摘A modified Hummer's method was adopted for the synthesis of graphene oxide(GO) and reduced graphene oxide(rGO). It was revealed that the modified method is effective for the production of GO and rGO from graphite. Transmission electron microscopy(TEM) images of GO and rGO showed a sheet-like morphology. Because of the presence of oxygenated functional groups on the carbon surface, the interlayer spacing of the prepared GO was higher than that of rGO. The presence of \OH and C_O groups in the Fourier transform infrared spectra(FTIR) spectrum and G-mode and 2D-mode in Raman spectra confirmed the synthesis of GO and rGO. rGO(292.6 m^2/g) showed higher surface area than that of GO(236.4 m^2/g). The prepared rGO was used as an adsorbent for benzene and toluene(model pollutants of volatile organic compounds(VOCs)) under dynamic adsorption/desorption conditions. rGO showed higher adsorption capacity and breakthrough times than GO. The adsorption capacity of rGO for benzene and toluene was 276.4 and 304.4 mg/g, respectively.Desorption experiments showed that the spent rGO can be successfully regenerated by heating at 150.0°C. Its excellent adsorption/desorption performance for benzene and toluene makes rGO a potential adsorbent for VOC adsorption. | Lian Yu Long Wang Weicheng Xu Limin Chen Mingli Fu Junliang Wu Daiqi Ye | 2018 | Journal of Environmental Sciences2018，30，5： | 10 |
| 17 | Effect of spinal cord extracts after spinal cord injury on proliferation of rat embryonic neural stem cells and Notch signal pathway in vitro显示文摘Objective:To investigate the effect of the spinal cord extracts(SCE)after spinal cord injuries(SCIs)on the proliferation of rat embryonic neural stem cells(NSCs)and the expressions of mRNA of Notch1 as well as of Hes1 in this process in vitro.Methods:The experiment was conducted in 4 different mediums:NSCs+PBS(Group A-blank control group),NSCs+SCE with healthy SD rats(Croup B-normal control group),NSCs+SCE with SD rats receiving sham-operation treatment(Croup C-sham-operation group)and NSCs+SCE with SCIs rats(Group D-paraplegic group).Proliferative abilities of 4 different groups were analyzed by MTT chromatometry after co-culture for 1,2,3,4 and 5 d,respectively.The expressions of Notch 1 and Hes1 mRNA were also detected with RT-PCR after co-culture for 24 and 48 h,respectively.Results:After co-culture for 1,2,3,4 and 5 d respectively,the MTT values of group D were significantly higher than those of group A,group B and group C(P<0.05).However,there were no significantly differences regarding MTT values between group A,group B and group C after co-culture for 1,2,3,4 and 5 d,respectively(P>0.05).Both the expressions of Notch1 and Hes1 mRNA of group D were significantly higher than those of other 3 groups after co-culture for 24 h and 48 h as well(P<0.05).But there was no difference oin expressions of Notch1 and Hes1 mRNA among group A,group B and group C after co-culture for 24 h and 48 h(P>0.05).There was no difference in expressions of Notch1and Hes1 mRNA between 24 h and 48 h treatment in group D.Conclusions:SCE could promote the proliferation of NSCs.It is demonstrated that the microenvironment of SCI may promote the proliferation of NSCs.Besides,SCE could increase the expression of Notch1 and Hes1 mRNA of NSC.It can be concluded that the Notch signaling pathway activation is one of the mechanisms that locally injured microenvironment contributes to the proliferation of ENSC after SCIs.This process may be performed by up-regulating the expressions of Notch1 and Hes1 gene. | Qing-Zhong Zhou Ge Zhang Hai-Bo Long Fei Lei Fei Ye Xu-Feng Jia Yun-Long Zhou Jian-Ping Kang Da-Xiong Feng | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，7： | 9 |
| 18 | Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials:a review显示文摘Magnesium(Mg)or its alloys are widely tested as potential orthopedic implants,particularly as biodegradable alloys for fracture fixation due to their mechanical properties are close to those of bone.Currently,available Mg or its alloys are confronted with challenges in passing regulatory biosafety tests prior to clinical trials due to its fast degradation and associated degradation products.The degradation of Mg is accompanied by the release of Mg ions,the rise of pH and osmolality in surrounding environments.According to the standard of ISO 10993 Part 13,the pH value shall be appropriate to the site of intended use maintaining in an appropriate range.Approaches to overcome these challenges include the selection of adequate alloying elements,proper surface treatment techniques and control of the degradation rate of Mg or its alloys developed as orthopedic implants.To date,Mg or its alloy-based bone implants have not yet been widely used in clinical applications as medical implants.This review critically summarized published methods to improve the corrosion resistance of Mg and its alloys.The current progress on in vitro cytotoxicity and in vivo biocompatibility properties of these metals was also reviewed.This review aimed to provide a reference for further research and development(R&D)of biodegradable Mg and its alloys with regard to the evaluation of their corrosion process and biocompatibility and facilitation of their translation to clinical applications. | Long Li Ming Zhang Ye Li Jie Zhao Ling Qin Yuxiao Lai | 2017 | Regenerative Biomaterials2017，4，2： | 9 |
| 19 | Biodiversity-based development and evolution:the emerging research systems in model and non-model organisms显示文摘Evolutionary developmental biology,or Evo-Devo for short,has become an established field that,broadly speaking,seeks to understand how changes in development drive major transitions and innovation in organismal evolution.It does so via integrating the principles and methods of many subdisciplines of biology.Although we have gained unprecedented knowledge from the studies on model organisms in the past decades,many fundamental and crucially essential processes remain a mystery.Considering the tremendous biodiversity of our planet,the current model organisms seem insufficient for us to understand the evolutionary and physiological processes of life and its adaptation to exterior environments.The currently increasing genomic data and the recently available gene-editing tools make it possible to extend our studies to non-model organisms.In this review,we review the recent work on the regulatory signaling of developmental and regeneration processes,environmental adaptation,and evolutionary mechanisms using both the existing model animals such as zebrafish and Drosophila,and the emerging nonstandard model organisms including amphioxus,ascidian,ciliates,single-celled phytoplankton,and marine nematode.In addition,the challenging questions and new directions in these systems are outlined as well. | Long Zhao Feng Gao Shan Gao Yujun Liang Hongan Long Zhiyi Lv Ying Su Naihao Ye Liusuo Zhang Chengtian Zhao Xiaoyu Wang Weibo Song Shicui Zhang Bo Dong | 2021 | Science China(Life Sciences)2021，64，8： | 9 |
| 20 | Prospects and Problems for Identification of Poisonous Plants in China using DNA Barcodes显示文摘Objective Poisonous plants are a deadly threat to public health in China. The traditional clinical diagnosis of the toxic plants is inefficient, fallible, and dependent upon experts. In this study, we tested the performance of DNA barcodes for identification of the most threatening poisonous plants in China. Methods Seventy-four accessions of 27 toxic plant species in 22 genera and 17 families were sampled and three DNA barcodes(matK, rbcL, and ITS) were amplified, sequenced and tested. Three methods, Blast, pairwise global alignment(PWG) distance, and Tree-Building were tested for discrimination power. Results The primer universality of all the three markers was high. Except in the case of ITS for Hemerocallis minor, the three barcodes were successfully generated from all the selected species. Among the three methods applied, Blast showed the lowest discrimination rate, whereas PWG Distance and Tree-Building methods were equally effective. The ITS barcode showed highest discrimination rates using the PWG Distance and Tree-Building methods. When the barcodes were combined, discrimination rates were increased for the Blast method. Conclusion DNA barcoding technique provides us a fast tool for clinical identification of poisonous plants in China. We suggest matK, rbcL, ITS used in combination as DNA barcodes for authentication of poisonous plants. | XIE Lei WANG Ying Wei GUAN Shan Yue XIE Li Jing LONG Xin SUN Cheng Ye | 2014 | Biomedical and Environmental Sciences2014，27，10： | 9 |
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