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262篇 您的检索式:作者名="Lowe H C"
    题名 作者 年代 出处 被引量
1胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) 2018神经损伤与功能重建2018,13,9:2
2On the reconfiguration of de- gradable VLSI/WSI arrays显示文摘Low C P Leong H W 1997IEEE Trans Comput- er-Aided Design of Integrated Circuits and Systems1997,16,10:1
3Coronary in-stent restenosis:current status and future strategies显示文摘LOWE H C OESTERLE S N KHACHIGIAN L M 2002J Am Coll Cardiol2002,39,2:1
4Polycystin-1,STAT6,and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease显示文摘Low S H Vasanth S Larson C H 2006Dev Cell2006,10,1:1
5The relative importance of non-sea-salt sulphate and sea-salt aerosol to the marine cloud condensation nuclei population:Animproved multi-component aerosol-cloud droplet parametrization显示文摘O'Dowd C D Lowe J A Smith M H 1999Quart J Roy Meteor Soc1999,125,556:1
6Heuristic solutions to multidepot location-routing problem显示文摘Wu T H Low C Bai J W 2002Computers&Operations Research2002,29,:1
7Preparation of mixed-matrix membranes for micellar enhanced ultrafiltration based on response surface methodology显示文摘Ngang H P Ahmad A L Low S C 2012Desalination2012,293,:1
8Coronary instent restenosis:current status and future strategies显示文摘Lowe H C Oesterle S N Khachigian L M 2002J Am Coll Cardiol2002,39,21:1
9Polycystin-1,STAT6,and p100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease显示文摘LOW S H VASANTH S LARSON C H 0,,01:1
10A Retrospective Evaluation of Operative Treatment of Ankle Fractures显示文摘Low C K Pang H Y Wong H P 1997Ann Acad Med Singapore1997,26,:1
11Video parsing and browsing using compressed data 显示文摘Zhang H J Low C Y Smoliar S W 1995Multimedia Tools and Applications1995,1,1:1
12Novel ,affinity separations based on perfluorocarbon emulsions : Use of a perfluorocarbon affinity emulsion for the direct extraction of glucose-6-phosphate dehydrogenase from homogenised bakers' yeast 显示文摘McCreath G E Chase H A Lowe C 1994J Chromatogra A1994,659,2:1
13Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells显示文摘Pepper C Lowe H Fegan C 2007Br J Cancer2007,97,2:1
14Heuristic solutions to multi-depot location-routing problems显示文摘Wu T H Low C Bai J W 2002Computers and Operations Research2002,9,10:1
15Heuristic solutions to multi- depot location-routing problems 显示文摘Wu T H Low C Bai J W 2002Computers and Operations Research2002,29,:1
16Internet congestion control显示文摘Low S H Paganini Doyle J C 2002IEEE Control Systems Magazine2002,22,1:1
17Microstructures and dislocation configurations in nanostructured Cu processed by repetitive corrugation and straightening 显示文摘HUANG J Y ZHU Y T JIANG H LOWE T C 2001Acta Materia2001,49,9:1
18Energy and exergy analysis of simple solid-oxide fuel-cell power systems显示文摘S H Chan C F Low O L Ding 2002Journal of Power Sources2002,103,:1
19Polycystin-1,S-TAT6,and p100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease显示文摘LOW S H VASANTH S LARSON C H 2006Dev Cell2006,10,1:1
20Energy and exergy analysis of a simple solid-oxide fuel cell power system 显示文摘Chan S H Low C F Ding O L 2002Journal of Power Sources2002,103,2:1
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