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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 小鼠脊髓重与颈膨大截面积QTL研究(英文)显示文摘应用近交系小鼠A/J和C5 7BL/ 6J以及其F2 代重组小鼠定位脊髓重与颈膨大截面积数量性状基因座(QuantitativeTraitLoci,QTL)。结果表明 13个QTL与脊髓重和截面积相关 ,这些QTL分别位于 2、4、8、14、15、17、18、19和X染色体上。其中 6个QTL与脊髓重相关 ;4个QTL与颈膨大截面积相关 ;3个QTL与二者均相关。在 13个QTL中 ,3个QTL (P <0 0 1)———SC1(位于D15Mit15 8附近 )、SC2 (DXMit14 0附近 )和SC3(DXMit6 4附近 )其表型变异的解释率分别为 2 4 %、19%和 15 % ;加性效应分别为 - 3 78、3 4 1和 2 0 6mg。其他QTL的P值在 0 0 1~ 0 0 5之间。在上述 3个QTL中 。 | 谭湘陵 周艳 蔡可夫 绍义祥 朱顺星 Lu L Williams R W 顾晓松 | 2004 | Acta Genetica Sinica2004，31，8： | 3 |
| 3 | Comparison of antioxidant activity of clove ( Eugenia caryophylata Thunb) buds and lavender ( Lavandula stoechas L.)显示文摘 | ìlhami Gül?in ?. Güng?r ?at ?ükrü Beydemir Mahfuz Elmasta? ?. ?rfan Küfrevio?lu | 2004 | Food Chemistry2004，，3： | 3 |
| 4 | Genome-level analysis of genetic regulation of liver gene expression networks显示文摘 | Gatti, D Maki, A Chesler, EJ Kirova, R Kosyk, O Lu, L Williams, RW Perkins, A Langston, MA Threadgill, DW Rusyn, I | 2007 | 中国生物学文摘2007，21，11： | 3 |
| 5 | Preparation and Evaluation of Zidovudine-loaded Sustained-release Microsuheres显示文摘 | Abu-lzza K A Garcia-Contreras L Lu D R | 1996 | J Pharm Sci1996，85，6： | 3 |
| 6 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 7 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 8 | Al2O3对赤铁矿烧结过程的影响显示文摘主要分析了Al2O3对烧结过程“初熔”相物理化学特性的影响,阐述了含有不同形态Al2O3,的高铝铁矿石对烧结矿结构、烧结矿质量以及烧结过程的影响,探讨了Al2O3,对烧结矿低温还原粉化性能(RDI)的影响机理,提出了3种解决高铝铁矿石烧结的方法(中和法、稀释法、富集法),并简述了优化烧结原料以及烧结过程的可行措施。 | L Lu R J Holmes J R Manuel 张代华(译) 周茂军(校) | 2007 | 世界钢铁2007，7，5： | 2 |
| 9 | A new kinetic modal for the NO-carbon reaction 显示文摘 | Li Y H Radovic L R Lu G Q | 1999 | Chemical Engineering Science1999，，54： | 1 |
| 10 | Biofeedback for robotic gait rehabilitation显示文摘 | Lu nenburger L Colombo G Riener R | 2007 | Neuroengineering Rehabil2007，，4： | 1 |
| 11 | Surface nanocrystallization of iron induced by ultrasonic shot peening显示文摘 | TAO N R SUI M L LU J | 1999 | Nanostructured Materials1999，11，4： | 1 |
| 12 | An XML multi-signature scheme显示文摘 | LU E J L CHEN R F | 2004 | Applied Mathematics and Computation2004，，149： | 1 |
| 13 | Antioxidant activities of polyphenols from sage 显示文摘 | Lu Y R Wang Q L Liu X Y | 2001 | Food Chem2001，75，2： | 1 |
| 14 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 15 | The genomes of sheeppox and goatpox viruses 显示文摘 | Tulman E R Afonso C L Lu Z | 2002 | J Virol2002，76，12： | 1 |
| 16 | Effects of t yroserleutide on gene expression of calmodulin and PI3K in hepatocellular carcinoma显示文摘 | Zhao L Zhao Q Lu R | 2008 | Cell Biochem2008，103，2： | 1 |
| 17 | Silver nanoparticles in-hibit hepatitis B virus replication显示文摘 | Lu L Sun RW Chen R | 2008 | Antivir Ther2008，13，2： | 1 |
| 18 | A mechanical calculation of the flexible & floating anti-ship collision device for bridge piers显示文摘 | Lti W Lu R L Ning X L | 2012 | Advanced Materials Research2012，，： | 1 |
| 19 | MicroRNA-125b down-regulation mediates endometrial cancer invasion by targeting ERBB2显示文摘 | Shang C Lu Y M Meng L R | 2012 | Med Sci Monit2012，18，4： | 1 |
| 20 | Large-scale seroprevalence anal- ysis of human metapneumovirus and human respiratory syneytial vi- res infections in Beijing, China显示文摘 | Lu G Gonzalez R Guo L | 2011 | Viral J2011，8，： | 1 |
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