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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Effects of ethanol consumption on hepatic hemodynamics in patients with alcoholic cirrhosis显示文摘 | A Luca JC Garcia-Pagan J Bosch F Feu J Caballeria RJ Groszmann J Rodes | 1997 | Gastroenterology1997，，4： | 3 |
| 3 | Interleukin-1 increases fibronectin production by cultured rat cardiac fibroblasts显示文摘 | Lucas F Jesus A Mosquera | 2002 | Pathobiology2002，70，4： | 1 |
| 4 | Transformation of maltose into prebiotic isomahooligosaccharides by a novel &-glucosidase from Xantophyllomyces dendrorhous 显示文摘 | Luca F A Dolores M Aranzazu G | 2007 | Process Biochemistry2007，42，： | 1 |
| 5 | Formation of the structure of chars during devolatilization of pulverized coal and its thermoproperties: a review 显示文摘 | Yu J Lucas J A Wall T F | 2007 | Progress in Energy and Combustion Science2007，33，2： | 1 |
| 6 | Influence of the Ion Exchanged Metal (Cu, Co, Ni and Mn) on the Se- lective Catalytic Reduction of NOz Over Mordenite and ZSM-5 显示文摘 | De Lucas A Valverde J L Dorado F | 2005 | Journal of Molecular Catalysis A: Chemical2005，225，1： | 1 |
| 7 | Longevity of direct resin composite restorations in posterior teeth显示文摘 | Brunthaler A Konig F Lucas T | | 0，，： | 1 |
| 8 | Characterization of a new kerati nolytic bacterium that completely degrades native feather ker- atin 显示文摘 | Riffel A Lucas F Heeb P | 2003 | Archives of Microbiology2003，179，4： | 1 |
| 9 | Characterization of a new keratinolytic bacterium that completely degrades native feather keratin 显示文摘 | Riffel A Lucas F Heeb P | 2003 | Arch Microbiol2003，179，： | 1 |
| 10 | Formation of the Structure of Chars During Devolatilization o{ Pulverized Coal and its Thermoproperties : A Review显示文摘 | Yu Jianglong Lucas J A Wall T F | 2007 | Progress in Energy and Combustion Science2007，33，： | 1 |
| 11 | Longevity of direct resin composite restorations in posterior teeth显示文摘 | Brunthaler A Konig F Lucas T | 2003 | Clin Oral Investig2003，7，2： | 1 |
| 12 | State Space Formulation for Linear Viscoelastic Dynamic Systems with Memory 显示文摘 | PALMERI A RICCIARDELLI F DE LUCA A | 2003 | Journal of Engineering Mechanics2003，129，7： | 1 |
| 13 | Poly ( ethylene-co-vinylacetate) ( EVA) as wax in hibit or of a Brazili an crude oil: oilviscosity, pour point and phase behavior of organic solutions 显示文摘 | Machado A L C Lucas E F Gonzalez G | 2001 | Journal of Petroleum Science and Engineering2001，32，234： | 1 |
| 14 | The effects of tertiary wastewater treatment on the prevalence of antimicrobial re- sistant bacteria显示文摘 | Luca G Danilo M A Lo F W | 2002 | Water Research2002，36，： | 1 |
| 15 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 16 | State Space Formulation for Linear Viscoelastic Dynamic Systems with Memory 显示文摘 | PALMERI A RICCIARDELLI F DE LUCA A | 2003 | Journal of Engineering Mechanics2003，129，7： | 1 |
| 17 | Formation of the structure of chars during devolatilization of pulverized coal and its thermoproperties: A review显示文摘 | Yu J L Lucas J A Wall T F | 2007 | Progress Energy Combust2007，33，2： | 1 |
| 18 | Longevity of direct resin com- posite restorations in posterior teeth:a review显示文摘 | Brunthaler A Knig F Lucas T | 2003 | Clinical Oral In- vestigations2003，7，2： | 1 |
| 19 | Poly (ethylene-co-vinyl acetate)(EVA)as wax inhibitor of a Brazilian crude oil:Oil viscosity, pour point and phase behavior of organic solutions显示文摘 | MACHADO A L C LUCAS E F GONZáLEZ G | 2001 | Journal of Petroleum Science and Engineering2001，32，2： | 1 |
| 20 | Multi-- channel Surface EMG Classification Using Support Vector Machines and Signal--based Wavelet Optimization显示文摘 | Lucas M F Gaufriau A S Pascual S | 2008 | Biomedical Signal Processing and Control2008，3，2： | 1 |
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