|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair显示文摘Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical repair.Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele.This study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and postoperatively.The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate.There were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two groups.The NTA group had a higher preoperative DFI than the TA group.Both groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and DFI.The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA group.Both TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA group.However,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group. | Parviz K Kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen Keikhosrow M Kavoussi Amy Esqueda J David Wininger Shahryar K Kavoussi | 2021 | Asian Journal of Andrology2021，23，2： | 2 |
| 3 | Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology显示文摘 | Luke J M Monika A T Alejandro N | 2013 | Journal of Medical Microbiolo- gy2013，62，2： | 1 |
| 4 | Executive Function and Theory of Mind: Stability and Prediction from Ages 2 to 3 显示文摘 | Stephanie M C Dorothy J M Luke W | 2004 | Developmental Psychology2004，40，6： | 1 |
| 5 | Nuclear magnetic resonance imaging in multiple sclerosis 显示文摘 | Lukes S A Crookes L E Aminoff M J | 1983 | Ann Neurol1983，13，： | 1 |
| 6 | Meat Analysis;convalescent blood products for Spanish influence pheumonis:a future H5N1 treatment显示文摘 | LUKE T C KILBANE E M JACKSON J L | 2006 | Ann Intern Med2006，145，： | 1 |
| 7 | The novel use of decorin in prevention of the develop- ment of proliferative vitreoretinopathy (PVR) 显示文摘 | Nassar K LuKe J LuKe M Kamal M Abd EI-Nabi E Soliman M | 2011 | Graefes Arch Clin Exp Ophthalmol2011，249，11： | 1 |
| 8 | Adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted reproductive technology treatment显示文摘 | Stern J E Luke B Tobias M | 2015 | Fertility and sterility2015，103，6： | 1 |
| 9 | Strategic hospital alli-ances:do the type and market structure of strategic hospital alli-ances matter?显示文摘 | MCCUE M J CLEMENT J P LUKE R D | 1999 | Medical care1999，37，10： | 1 |
| 10 | Universal correlations between Tc and ns/m (carrier density over effective mass) in High-Tc Cuprate superconductors 显示文摘 | UEMURA Y J LUKE G M STERNLIEB B J | 1989 | Phys Rev Lett1989，62，： | 1 |
| 11 | Melasma in Latin Americans显示文摘 | Perez M Luke J Rossi A | 2011 | J Drugs Dermatol2011，10，5： | 1 |
| 12 | Purple nutsedge (Cyperus rotundus) competition with sugarcane and response to shade 显示文摘 | Heredge E T Luke M J Griffin J L | 2010 | Journal American Society of Sugar Cane Technologists2010，30，： | 1 |
| 13 | The value of urbanopen space : Meta-analyses of contingent valuation andhedonic pricing results 显示文摘 | Brander Luke M Koetse Mark J | 2011 | Journal of EnvironmentalManagement2011，92，5： | 1 |
| 14 | Universal correlations between Tc and ns/m* (carrier density over effectivie Mass)in high-Tc cuprate superconductors显示文摘 | Y J Uemura G M Luke B J Sternlieb | 1989 | Physical Review Letters1989，62，19： | 1 |
| 15 | Elbow arthros- copy in the pediatric and adolescent population 显示文摘 | Micheli L J Luke A C Mintzer C M | 2001 | Ar- throscopy2001，17，7： | 1 |
| 16 | Phylogeny of Trypanosomesas inferred from the small and large subunit rRNAs:Implieations for the evolution of parasitism in the Trypanosomatid protozoa 显示文摘 | Maslov D A Lukes J Jirku M | 1996 | Mol Biochem Parasitol1996，75，： | 1 |
| 17 | Analysis oribosomal RNA genes suggests that Trypanosomes are monophyletic显示文摘 | Lukes J Jirku M Dolezel D | 1997 | J Mol Evol1997，44，： | 1 |
| 18 | Mapping agricultural land use using retrospective ground referenced data, satellite sensor imagery and GIS显示文摘 | Baban S M J Luke C | 2000 | International Journal of Remote Sensing2000，21，8： | 1 |
| 19 | A review of bioohars ' potential role in the remediation,revegeta-tion and restoration of contaminated soils 显示文摘 | Luke B Eduardo M J Jose L G Eva H Brett R Tom S | 2011 | Environmental Pollution2011，，159： | 1 |
| 20 | The configuration of ( + )- s - ( 1 - propenyl)- 1- cysteine s- oxide from Allium cepa 显示文摘 | Carson J F Lundin R E Lukes T M | 1966 | J Org Chem1966，31，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员