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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Recent developments in semiconductor gamma-ray detectors 显示文摘 | Luke P N Amman M TindaU C | 2005 | Journal of Radloanalyrical and Nuclear Chemistry2005，264，1： | 1 |
| 3 | Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor显示文摘 | Sven P Luke M | 2000 | Clin Cancer Res2000，，6： | 1 |
| 4 | Economic analysis in the MRO in- dustry: an options approach 显示文摘 | LUKE T M CHAN S P | 2004 | The Engineering Econo- mist2004，49，5： | 1 |
| 5 | The Associ- ation of Surgical Margins and Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy: A Meta-Analysis显示文摘 | Houssami N Macaskill P Luke Marinovich M | 2014 | Ann Surg Oncol2014，21，3： | 1 |
| 6 | Iron overload and heart fibrosis in mice deficient for both β2- microglobulin and Ragl 显示文摘 | MANUELA M S MARIA D S LUKE H P | 2000 | Am J Pathol2000，157，6： | 1 |
| 7 | Strategic hospital alli-ances:do the type and market structure of strategic hospital alli-ances matter?显示文摘 | MCCUE M J CLEMENT J P LUKE R D | 1999 | Medical care1999，37，10： | 1 |
| 8 | Real time visualisation and analysis of dense phase powder conveying显示文摘 | Ostrowski K Luke S P Bennett M A | 1999 | Power Technology1999，102，1： | 1 |
| 9 | Coplanar- grid Detector with Single- electrode Readout 显示文摘 | Luke P N | 1997 | Proceeding of SPIE1997，3115，： | 1 |
| 10 | Biochar addition to an arsenic contami- nated soil increases arsenic concentrations in the pore water but reduces uptake to tomato plants显示文摘 | Luke B Marta M Luca P | 2013 | Science of the Total Environment2013，，： | 1 |
| 11 | Real time visualisation and analysis of dense phase powder bonveying显示文摘 | Ostrowski K Luke S P Bennett M A | 1999 | Powder Technology1999，，102： | 1 |
| 12 | Application of capacitance electrical tomography for on-line and off-line analysis of flow pattern in horizontal pipeline of pneumatic conveyer 显示文摘 | Ostrowski K L Luke S P Bennett M A | 2000 | Chemical Engineering Journal2000，，77： | 1 |
| 13 | Learning symbolic models of stochastic domains 显示文摘 | Hanna M P Luke S Z Leslie P K | 2007 | Journal of Artificial Intelligence Re- search2007，29，1： | 1 |
| 14 | 查看详情显示文摘 | Lukes P Clupek M Babicky V | | 0，，： | 1 |
| 15 | Pre-induction and induction hydration of tricalciun silicate : an environmental scanning electron microscopy syudy 显示文摘 | Meredith P Donald A M Luke K | 1995 | J Mater Sci1995，39，： | 1 |
| 16 | Detection of supercooled liquid in mixed - phase clouds using radar Doppler spectra显示文摘 | Luke E P Kollias P Shupe M D | 2010 | Journal of Geophysical Research: Atmospheres ( 1984 - 2012 )2010，115，： | 1 |
| 17 | Real time visualization and analysis of dense phase powder conveying 显示文摘 | Ostrowski K L Luke S P Bennet M A Wilhams R A | 1999 | Powder Technology1999，102，1： | 1 |
| 18 | Economic analysis in the MRO industry: An options approach 显示文摘 | Luke T M Chan S P | 2004 | The Engineering Economist2004，49，1： | 1 |
| 19 | Degradation of phenol by under-water pulsed corona discharge in combination with TiO2 photocatalysis显示文摘 | Lukes P Clupek M Sunka P | | 0，，： | 1 |
| 20 | Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor显示文摘 | Cordula P Sven P Luke M | 2000 | Clin Cancer Res2000，6，6： | 1 |
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