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| 1 | Mechanisms and major sites of distal catheter migration in ventriculoperitoneal shunting maneuvers: A review article显示文摘A ventriculoperitoneal shunt(VPS) is a medical device used to deflect cerebrospinal fluid from cerebral ventricles to the peritoneal cavity. Since 1908, ventriculoperitoneal shunts have been considered the best option in hydrocephalus management. Manifestation related to VPS may arise anywhere whilst tunneling the VPS from the ventricle to the peritoneal cavity, but complications associated with the distal catheter are especially common and a leading cause of revision surgeries. Among the many complications associated with peritoneal shunts, migration of the catheter into other parts of the body is still common. Scrotal migration mainly takes place in children aged 4 days to 5 years. Patent processus vaginalis, formation of an inguinal hernia, and increased intraabdominal pressure are leading risk factors associated with migration of the peritoneal catheter into the scrotum. Thoracic migration of peritoneal catheters predominantly occurs in adult patients. Important mechanisms in thoracic migration include(1) iatrogenic perforation of the external or internal jugular veins by the surgeon during tunneling and(2) gradual destruction of the venous structures by the catheter due to routine extension and flexion of the neck. After entering the vessel, negative intrathoracic pressure combined with positive intraabdominal pressure aids migration into the thoracic cavity. Sharp tips or shunt types contribute to intraabdominal migration and perforation. | Ismatullah Soufiany Khalil Ahmad Hijrat Spina Soufiany Lukui Chen | 2018 | Translational Neuroscience and Clinics2018，4，2： | 2 |
| 2 | RGD-FasL Induces Apoptosis of Pituitary Adenoma Cells显示文摘This study was to investigate the cytotoxic effects on pituitary adenoma cell lines GH3/MMQ/AtT20 induced by RGD-FasL and the underlying mechanism. Fas/DcR3 mRNAs were detected by RT-PCR and their surface expressions were measured by flow cytometry. Cytotoxicity exerted by RGD-FasL on tumor cells was measured with MTT assay and the induced apoptosis was determined by agarose gel electrophoresis. The cell cycle and apoptosis was assessed by flow cytometry with PI staining. The expressions of caspase8/9/3,Bcl-2,RANKL and JNK2 were detected by Western blotting. Approximately 13.7% of GH3 cells,25.5% of MMQ cells,22.2% of AtT20 cells express Fas,while 23.9% of GH3 cells,24.1% of MMQ cells,4.6% of AtT20 cells express DcR3. The cytotoxic effects of FasL/RGD-FasL on tumor cells were all taken in a dose-dependent manner. Cell lines MMQ/AtT20 showed the same sensitivity to RGD-FasL as to FasL,while cell line GH3 was less sensitive to RGD-FasL. The cell cycle analysis indicated that RGD-FasL could inhibit cells in G0/G1 phase and G2/M phase. In MMQ and AtT20 cells treated with RGD-FasL,the AI was not significantly different from that treated with FasL,while in GH3 cells treated with RGD-FasL,the AI was lower than that treated with FasL. The expressions of caspase-8/9/3,RANKL and JNK2 were increased while that of Bcl-2 was decreased after treatment with RGD-FasL,suggesting that RGD-FasL induces apoptosis through caspase activation. We concluded that RGD-FasL could possibly be considered as a novel therapeutical candidate for the treatment of pituitary adenomas. | Lukui Chen Guohong Zhuang Wenzhu Li Yunsheng Liu Junqing Zhang Xinhua Tian | 2008 | Cellular & Molecular Immunology2008，5，1： | 2 |
| 3 | Bypass surgery for ischemic stroke caused by intracranial artery stenosis or occlusion显示文摘Surgical revascularization may be beneficial in patients with ischemic stroke caused by intracranial stenosis or occlusion who are ineligible for thrombolysis. Objective: To evaluate the outcome of superficial temporal artery to middle cerebral artery(STA-MCA) bypass in ischemic stroke caused by intracranial artery stenosis or occlusion. Methods: We retrospectively studied successive case series of 19 patients who underwent surgical treatment between 2013–2017 of STA-MCA bypass. Surgical procedure was performed for the patients with acute ischemic stroke who were ineligible for thrombolysis. Results: Of the 19 patients enrolled, symptom aggravation occurred during medical treatment, the patients were ineligible for thrombolysis despite being within 8 hours of symptom onset. Bypass significantly improved National Institutes of Health Stroke Scale scores, mean patient age was 78.05 years(range, 39-78 y). However, male 11(57.95%)out of nineteen patients were presented with left-sided-lesions while female 8(42%) had right-sided lesions with significant infarction growth by diffusion weighted imaging achieved, after surgical maneuver. No major complications occurred intraoperatively, in contrast to 2(10.5%) minor manifestation were suffering minor complications probably they included the remote infarction(posterior cerebral artery territory). Pooled analysis with our patients showed a significant neurological improvement and a good outcome in 13(68.4%) patients without hemorrhage or any other complication, 6(31.6%) patients with unfavorable outcome(severe disability 2; vegetative state 4, non of them are died 0;). Conclusion: STA-MCA bypass may be beneficial to patients with acute stroke or stenosis in progress who are ineligible for medical therapy. Furthermore, it appears safe when the infarction is small. These findings indicate that STA-MCA bypass could be considered as a treatment option in selected patients with ischemic stroke caused by intracranial stenosis or occlusion. | Ismatullah Soufiany Khalil Ahmad Hijrat Spina Soufiany Lukui Chen | 2018 | Translational Neuroscience and Clinics2018，4，1： | 1 |
| 4 | The safety and efficacy of magnetic nano-iron hypertherrnia therapy on rat brain gliorna 显示文摘 | YI Guoqing GU Bin CHEN Lukui | 2014 | Tumor Biology2014，35，3： | 1 |
| 5 | Management of post-stroke neuropsychiatric disorders显示文摘Post-stroke neuropsychiatric(NP) disorders are common and have complex etiologies.Multiple factors such as lesion location, personality characteristics, socioeconomic status, pre-stroke psychiatric history, and family support are the determining factors in most cases. Although depression and anxiety are more common, emotional incontinence and catastrophic reactions are also frequently observed. Post-stroke depression(PSD)has been associated with an increased risk of stroke recurrence. Despite its serious consequences and high prevalence, PSD remains undetected and untreated. Treatment options of NP disorders depend on severity, presentation at the time of diagnosis, and patient cooperation, and include antidepressants, mood stabilizers, exercise therapy, psychotherapy, and even revascularization. The efficient management of NP disorders improves outcomes, quality of life, and survival rates in post-stroke patients. However,very few studies have identified definitive treatment for these patients; therefore, further research is required. | Ahsan Ali Khan Lukui Chen Guilong Zhang Xiaoyuan Guo Guojian Wu Hong Wang Yang You Yuchun Gu Yonggui Yuan | 2016 | Translational Neuroscience and Clinics2016，2，4： | 1 |
| 6 | Resection of intramedullary spinal cord tumor under awake anesthesia: A novel approach to minimize postoperative motor deficits显示文摘Objective: To observe advantages and disadvantages of the resection of intramedullary spinal cord tumor under awake anesthesia. Methods: Two patients with intramedullary spinal cord tumor underwent resection under awake anesthesia and followed up post-operatibely for any motor deficits. Results: Patients who underwent tumor resection under awake(AAA) anesthesia combined with intraoperative NPM had no motor deficits postoperatively. More accurate and nondelayed responses were observed in the awake cycle of anesthesia and helped guide surgery, thus avoiding injuries to the spinal cord. Conclusion: Intramedullary spinal cord tumors are not common, but only gross total resection(GTR) can provide complete remission of symptoms and progression-free survival. However, GTR sometimes results in motor function deficits postoperatively,particularly when the cervical cord is involved, and especially if surgery is done under general anesthesia with intraoperative neurophysiological monitoring(NPM) alone,because of delayed sensory evoked potential and motor evoked potential responses. We present two cases that underwent GTR of cervical intramedullary spinal cord tumors under an asleep-awake-asleep(AAA) cycle of anesthesia, combined with intraoperative NPM in which no post-operative motor deficits were observed on 6-months follow up. | Ahsan Ali Khan Lukui Chen Xiaoyuan Guo Hong Wang Guojian Wu Jun Kong Ning Yin | 2017 | Translational Neuroscience and Clinics2017，3，1： | 0 |
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