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| 1 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Planar chips technology for miniaturization and integration of separation techniques into monitoring systems:capillary electrophoresis on a chip 显示文摘 | MANZ A HARRISON D J VERPOORTE E M J | 1992 | Chromatography1992，593，： | 2 |
| 4 | Hepatitis delta virus显示文摘 | Sarah A Hughes Heiner Wedemeyer Phillip M Harrison | 2011 | The Lancet2011，，9785： | 2 |
| 5 | A general theory of acute and chronic heart {ailure显示文摘 | Maciver D H Dayer M J Harrison A J | 2013 | Int J Cardiol2013，165，1： | 1 |
| 6 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 7 | Time-series-based prediction of complex oscillator networks via compressive sensing显示文摘 | Wang W X Yang R Lai Y C Kovanis V Harrison M A F | 2011 | EPL2011，94，48： | 1 |
| 8 | The JAK/STAT Signaling Pathway显示文摘 | Rawlings J S Rosler K M Harrison D A | 2004 | J Cell Sci2004，17，： | 1 |
| 9 | The vacuolar H^+-ATPase:a universal proton pump of eukaryotes显示文摘 | FINBOW ME HARRISON MA | 1997 | Biochem J1997，324，3： | 1 |
| 10 | Factors associated with pressure ulcers in adults in acute care hospitals显示文摘 | FISH ER A R WELL S G HARRISON M B | 2004 | Holist Nurs Pract2004，18，5： | 1 |
| 11 | Risk and predictors forpregnancy-related complications in women with heart disease 显示文摘 | Siu S C Sermer M Harrison D A | 1997 | Circulation1997，96，9： | 1 |
| 12 | Developmental vari- ation in cytochrome P450 expression in Papilio polyxenes in re- sponse to xanthotoxin, a hostplant allelochemicals 显示文摘 | Harrison T L Zangerl A R Schuler M A | 2001 | Archives of Insect Biochemistry Physiology2001，48，4： | 1 |
| 13 | Does direct foreign investment affect domestic firm credit constraints显示文摘 | HARRISON A MCMILLAN M | | 0，，01： | 1 |
| 14 | Current and emerging therapies in nonalcoholic fatty liver disease显示文摘 | KASHI M R TORRES D M HARRISON S A | 2008 | Semin Liver Dis2008，28，： | 1 |
| 15 | Cretaceous - Tertiary shortening, basin development, and volcanism in central Tibet 显示文摘 | KAPP P YIN A HARRISON T M | 2005 | Geological Society of America Bulletin2005，117，78： | 1 |
| 16 | Selective regulation of myofiber differentiation by energy status during postnatal development 显示文摘 | Harrison A P Rowlerson A M Dauncey M J | 1996 | Am J Physiol-Reg I1996，270，3： | 1 |
| 17 | Collaborative computational projects显示文摘 | TENNYSON J HARRISON N M | 1994 | Comput Sci News1994，4，： | 1 |
| 18 | Stable carbon isotope ratio analysis of Australian orange juices 显示文摘 | SIMPKINS W A PATEL G HARRISON M | 2000 | Food Chem2000，70，： | 1 |
| 19 | A tectonic model for Cenozoic igneous activities in the eastern Indo-Asian collision zone显示文摘 | Wang J H Yin A Harrison T M | 2001 | Earth and Planetary Science Letters2001，188，12： | 1 |
| 20 | Fate of Listeria monocyto genes and Aeromonas hydrophilia on packaged channel catfish fillets stored显示文摘 | Leung C K Huang Y W Harrison M A | 1992 | Journal of Food Protection1992，55，9： | 1 |
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