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| 1 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 2 | /Banat Purification and characterization of a 54KDa chitinase from Bombyx mori Insect 显示文摘 | Babiker M A A | 1999 | Biochemistry and molecular Biology1999，29，： | 1 |
| 3 | Rapid and sim- ple method for isolating malaria DNA from fingerprick samples of blood显示文摘 | Foley M Ranford-Cartwright LC Babiker HA | 1992 | Mol Biochemi Parasitol1992，53，12： | 1 |
| 4 | Climate change policy, market structure,and carbon leakage显示文摘 | Babiker M H | 2005 | Journal of international Econom-ics2005，65，2： | 1 |
| 5 | Rapid and simple method for isolating malaria DNA from fingerprick samples of blood显示文摘 | Foley M Ranford-Cartwright LC Babiker HA | 1992 | Mol Biochem Parasitol1992，70，： | 1 |
| 6 | Influence of soil moisture on activity and persistence of the strigol analogue GR24显示文摘 | BABIKER A G T HANDOUN A M RUDWAN A MANSI M G FAKI H H | 1987 | Weed Research1987，27，： | 1 |
| 7 | Climate Change Policy, Market Structure, and Carbon Leakage显示文摘 | Babiker M H | 2005 | Journal of International Economics2005，65，： | 1 |
| 8 | A GIS-based DRASTIC model for assessing aquifer vulnerability in Kakamigahara Heights, Gifu Prefecture, Central Japan 显示文摘 | Babiker I S Mohamed M A A Hiyama T | 2005 | Sci Total Environ2005，345，13： | 1 |
| 9 | E//ect of protease digestion and dephosphorylation on high emulsifying properties of hen egg yolk phosvitin显示文摘 | Khan M S Babiker E E Azakami H | 1998 | Journal of Agricultural and Food Chemistry1998，46，： | 1 |
| 10 | Effect ofseason on contractile and metabolic properties of desert camelmuscle (camelus dromedarius )显示文摘 | Abdelhadi O M A Babiker S A Picard B | 2012 | Meat Science2012，90，1： | 1 |
| 11 | Emulsifying properties and bactericidal action of chitosan-lysozyme conjugates 显示文摘 | Song Y Babiker E E Usui M | 2002 | Food Research International2002，35，5： | 1 |
| 12 | Flash points and volatility characteristics of gasoline/diesel blends显示文摘 | A1-Abdullah M H Kalghatgi G T Babiker H | 2015 | Fuel2015，153，： | 1 |
| 13 | The orbital angu- lar momentum of light 显示文摘 | ALLEN L PADGETI' M J BABIKER M | 1999 | Progress in Optics1999，39，4： | 1 |
| 14 | The orbital angular momentum of light 显示文摘 | L Allen M J Padgett M Babiker | 1999 | Progress in Optics1999，54，5： | 1 |
| 15 | Climate change policy, market structure, and carbon leakage 显示文摘 | BABIKER M | 2005 | International Economics2005，65，2： | 1 |
| 16 | Evaluation of Nucleic Acid Sequencing of the D1/D2 Re- gion of the Large Subunit of the 28S rDNA and the In- ternal Transcribed Spacer Region Using SmartGene IDNS Software for Identification of Filamentous Fungi in a Clinical Laboratory 显示文摘 | Kwiatkowski N P Babiker W M Merz W G | 2012 | The Journal of Molecular Diagnostics2012，14，4： | 1 |
| 17 | Clinicopathological significance of PTEN and bcl2 expressions in oral squamous cell carcinoma显示文摘 | Rahmani A Alzohairy M Babiker AY | 2012 | Int J Clin Exp Pathol2012，5，9： | 1 |
| 18 | A GIS-based DRASTIC model for assessing aquifer vulnerability in Kakamigabara Heights, Gifu Prefecture, central Japan 显示文摘 | BABIKER I S MOHAMED M A A HIYAMA T | 2005 | Science of the Total Environment2005，345，： | 1 |
| 19 | An HIV-1 clade C DNA prime,NYVAC boost vaccine regimen induces reliable,polyfunctional,and long-lasting T cell responses显示文摘 | Harari A Bart PA St(o)hr W Tapia G Garcia M Medjitna-Rais E Burnet S Cellerai C Erlwein O Barber T Moog C Liljestrom P Wagner R Wolf H Kraehenbuhl JP Esteban M Heeney J Frachette MJ Tartaglia J McCormack S Babiker A Weber J Pantaleo G | 2008 | J Exp Med2008，205，1： | 1 |
| 20 | Accelera- tion of post-mortem tenderization in ovine carcasses through activation of Ca2-dependent proteases显示文摘 | KOOHMARAIE M BABIKER A S SCHROEDER A L | 1988 | Food Science1988，53，6： | 1 |
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