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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Gas producting parameters in sanitary landfill simula-tors显示文摘 | BARLAZ M A MIKE M W HAM R K | 1987 | Waste Management and Research1987，5，1： | 1 |
| 3 | Gas production parameters in sanitary landfill simulators 显示文摘 | M A Barlaz M W Mike R K Ham | 1987 | Waste Management and Research1987，5，1： | 1 |
| 4 | Is entrepreneur-politician alliance sustainable during transition?The case of management buyouts in China显示文摘 | PEI S MIKE W KAMEL M | 2010 | Management&Organization Review2010，6，1： | 1 |
| 5 | Multivariate analysis of heavy metal and nutrient concentrations in sediments of Taihu Lake, China 显示文摘 | Qu w C Mike D Wang S M | 2001 | Hydrobiologia2001，450，： | 1 |
| 6 | Gas production parameters in sanitary landfill simulators显示文摘 | BARLAZ M A MIKE M W HAM R K | 1987 | Waste Management and Research1987，，5： | 1 |
| 7 | Adenosine kinase of Arabidopsis.Kinetic properties and gene expression显示文摘 | Barbara A M Li W Mike S A Yvonne Y S,Wensheng Q,Jamie S,Klaus V S | | 0，，： | 1 |
| 8 | The Contingent Value of Corporate Political Ties显示文摘 | Sun P Kamel M Mike W | 2012 | Academy of Management Perspectives2012，26，3： | 1 |
| 9 | Denosine kinase deficiency in associated with developmental abnormalities and reduced transmethylation显示文摘 | Barbara A M Yvonne Y S Mike S A Jamie D S,Luiz A P,Margarita I T,Peter S S,Elizabeth A W,Luke M M,Conrad W A | | 0，，： | 1 |
| 10 | Partial hepatectomy induced liver proteome changes in mice显示文摘 | Christoph W S Mike S W Maciej M M | 2005 | Proteomics2005，5，1： | 1 |
| 11 | Tip squeezing显示文摘 | SHANE M TIM W MIKE C | 2008 | KiwiTech Bulle- tin2008，49，： | 1 |
| 12 | Gas production parameters in sanitary landfill simulators 显示文摘 | M A Barlaz M W Mike R K Ham | 1987 | Waste Management and Research1987，5，： | 1 |
| 13 | Partial hepatectomy induced liver proteome changes in mice显示文摘 | Christoph W S Mike S W Maciej M M | 2005 | Proteomics2005，5，1： | 1 |
| 14 | Partial hepatec- tomy induced liver proteome changes in mice 显示文摘 | Christoph W S Mike S W Maciej M | 2005 | Pro- teomics2005，5，1： | 1 |
| 15 | Compact multiplexing of monodisperse electrosprays显示文摘 | Weiwei D C Mike W Brian M | 2009 | Aerosol Science2009，40，10： | 1 |
| 16 | Evidence for an aquatic plant origin of ketones found in Taihu Lake sediments 显示文摘 | QU W C MIKE D WANG S M | 1999 | Hydrobiologia1999，397，： | 1 |
| 17 | Gas production parameters in sanitary landfill simulators 显示文摘 | BARLAZ M A MIKE M W HAM R K | 1987 | Waste Management and Research1987，5，1： | 1 |
| 18 | Market - political ambidexterity during institutional transitions显示文摘 | Yuan Li Mike W P Craig D M | 2013 | Strategic Organization2013，11，2： | 1 |
| 19 | Gas production parameters in sanitary landfill simulations显示文摘 | BALAZ M A MIKE M W HAM R K | 1987 | Waste Management and Research1987，，5： | 1 |
| 20 | Genetic polymorphisms associated with susceptibility and outcome in ARDS显示文摘 | RICHARD P M SUZANNE W B MIKE R H | 2002 | Chest2002，121，3： | 1 |
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