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1篇 您的检索式:作者名="M.Shadab Ali"
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1Long non-coding RNA(lncRNA):A potential therapeutic target in acute lung injury显示文摘Acute Lung Injury(ALI)and its severe form Acute Respiratory Distress Syndrome(ARDS)are the major cause of ICU death worldwide.ALI/ARDS is characterized by severe hypoxemia and inflammation that leads to poor lung compliance.Despite many advances in understanding and management,ALI/ARDS is still causing significant morbidity and mortality.Long non-coding RNA(lncRNA)is a fast-growing topic in lung inflammation and injury.lncRNA is a class of non-coding RNA having a length of more than 200 nucleotides.It has been a center of research for understanding the pathophysiology of various diseases in the past few years.Multiple studies have shown that lncRNAs are abundant in acute lung injury/injuries in mouse models and cell lines.By targeting these long non-coding RNAs,many investigators have demonstrated the alleviation of ALI in various mouse models.Therefore,lncRNAs show great promise as a therapeutic target in ALI.This review provides the current state of knowledge about the relationship between lncRNAs in various biological processes in acute lung injury and its use as a potential therapeutic target.Almaz Zaki M.Shadab Ali Vijay Hadda Syed Mansoor Ali Anita Chopra Tasneem Fatma 2022Genes & Diseases2022,9,5:2
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