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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Clinical Efficacy of Oral Ganciclovir for Prophylaxis and Treatment of Recurrent Herpes Simplex Keratitis显示文摘 | Xin Wang Linnong Wang Nianlang Wu Xinjun Ma Jianjiang Xu | 2015 | Chinese Medical Journal2015，，1： | 7 |
| 3 | Source and deposition of polycyclic aromatic hydrocarbons to Shanghai,China显示文摘Despite recent efforts to investigate the distribution and fate of polycyclic aromatic hydrocarbons (PAHs) in air, water, and soil, very little is known about their temporal change in wet deposition. As a result of increased attention to public health, a large-scale survey on the deposition flux and distribution of PAH contamination in rainwater was urgently conducted in Shanghai, China. In this study, 163 rainwater samples were collected from six sites, and 15 PAH compounds were detected by the use of a simple solid phase microextraction (SPME) technique coupled with gas chromatography-mass spectrometry. The dominant PAH species monitored were naphthalene, phenanthrene, anthracene, and fluoranthene. The concentration of total PAHs per event was between 74 and 980 ng/L, with an average value of 481 ng/L, which is at the high end of worldwide figures. The annual deposition flux of PAHs in rainwater was estimated to be 4148 kg/yr in the Shanghai area, suggesting rainfall as a major possible pathway for removing PAHs from the atmosphere. Diagnostic analysis by the ratios of An/178 and Fl/Fl+Py suggested that combustion of grass, wood, and coal was the major contributor to PAHs in the Shanghai region. Back trajectory analysis also indicated that the pollutant sources could be from the southern part of China. | Lili Yan Xiang Li Jianmin Chen Xinjun Wang Jianfei Du Lin Ma | 2012 | Journal of Environmental Sciences2012，24，1： | 4 |
| 4 | RHOBTB3 promotes proteasomal degradation of HIFa through facilitating hydroxylation and suppresses the Warburg effect显示文摘 | Chen-Song Zhang Qi Liu Mengqi Li Shu-Yong Lin Yongying Peng Di Wu Terytty Yang Li Qiang Fu Weiping Jia Xinjun Wang Teng Ma Yue Zong Jiwen Cui Chengfei Pu Guili Lian Huiling Guo Zhiyun Ye Sheng-Cai Lin | 2015 | Cell Research2015，25，9： | 2 |
| 5 | Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo: a time-series study显示文摘 | Wenhui Jiang Aiqun Ma Tingzhong Wang Ke Han Yu Liu Yanmin Zhang Anping Dong Yuan Du Xin Huang Jun Wang Xinjun Lei Xiaopu Zheng | 2006 | Pflügers Archiv - European Journal of Physiology2006，，1： | 1 |
| 6 | The Experimental Study of Relation between Type I Collagen, NF-κB, VCAM-1 and Atherosclerosis显示文摘 | Hongyan Wang Jianjie Zheng Aiqun Ma Xinjun Lei Xiaojun Bai Yili Wang | 2006 | Journal of US-China Medical Science2006，3，5： | 1 |
| 7 | Antithrombotic Management of Atrial Fibrillation Patients Presenting with Coronary Artery Disease:A Consensus Document of the Chinese Society of Cardiology显示文摘The coexistence of coronary artery disease(CAD)and atrial fibrillation(AF)is common in clinical practice.Patients with CAD require antiplatelet therapy to reduce the occurrence of myocardial ischemic events.However,patients with AF at high risk of thromboembolism require oral anticoagulants to reduce the occurrence of thromboembolic events such as stroke.In cases where CAD coexists with AF,the combined use of antiplatelet and anticoagulation therapy can effectively reduce the risk of ischemic and thromboembolic events but increase the risk of bleeding at the same time.The optimal antithrombotic regimen in patients with both CAD and AF has been controversial in clinical practice.In recent years,the expert consensuses on antithrombotic therapy in patients with AF presenting with acute coronary syndrome and/or undergoing percutaneous coronary intervention have been successively released in Europe and North America,and have been updated in a timely manner.In contrast,the guidelines on antithrombotic therapies in China are lacking.Based on published clinical evidence,this consensus incorporated relevant international and Chinese guidelines,consensuses,and expert recommendations,and addressed the issues encountered in the clinical practice of antithrombotic therapy in patients with AF and different types of CAD.The current guideline is of great significance to guide treatment in patients with both CAD and AF in China. | Chinese Society of Cardiology of Chinese Medical Association Editorial Board of Chinese Journal of Cardiology Zuyi Yuan Shulin Wu Yaling Han Peng Qu Shaowen Liu Changsheng Ma Yumei Xue Xinjun Lei | 2021 | Cardiology Discovery2021，1，1： | 1 |
| 8 | Delay-dependent robust stability of uncertain systems with multiple time-delays and nonlinear perturbations显示文摘 | MA Xinjun XU Bugong | 2004 | Journal of South China University of Technology (Natural Science Edition)2004，32，10： | 1 |
| 9 | Enhance the performance of polymer solar cells via extension of the flanking end groups of fused ring acceptors显示文摘Two new fused ring electron acceptors(FREAs)IDT-IC-T and IDT-IC-B with thienyl or phenyl substituents at the terminal INCN unit are synthesized.Theoretical calculations indicate that the two acceptors dominantly favor an intermolecularπ-πstacking between the flanking terminal groups.The twist angle between the aryl substituent and INCN unit has a significant influence on theπ-πstacking distance of terminal unit.IDT-IC-T with a smaller twist angle has a shorterπ-πstacking distance than that of IDT-IC-B with a larger twist angle.In addition,extending the conjugation also affects the blend film morphology.IDT-IC-T and IDT-IC-B based photoactive films show appropriate nanoscale phase separations;whereas,blend films based on the parent compound IDT-IC show large-size acceptor domains.As expected,PBDB-T:IDT-IC-T blend films show higher and more balanced electron and hole mobilities.Moreover,these two acceptors present a good charge-transport connectivity arising from the extended conjugation and the increased intermolecular overlapping.Ultimately,IDT-IC-T demonstrates the highest electron mobility(1.47×10^(-4)cm^2V^(-1)s^(-1))and the best power conversion efficiency(PCE)of 9.43%.As for IDT-IC,which only shows an electron mobility of 7.33×10^(-5)cm^2V^(-1)s^(-1)and a PCE of 5.82%.These findings provide a facile and effective way to improve the photovoltaic performance. | Shiyu Feng Danyang Ma Liangliang Wu Yahui Liu Cai'e Zhang Xinjun Xu Xuebo Chen Shouke Yan Zhishan Bo | 2018 | Science China Chemistry2018，61，10： | 0 |
| 10 | First-row transition metal compounds for aqueous metal ion batteries显示文摘In recent years,a series of aqueous metal ion batteries(AMIBs)has been developed to improve the safety and cost-efficiency of portable electronics and electric vehicles.However,the significant gaps in energy density,power density,and cycle stability of AMIBs directly hinder them from replacing the currently widely used non-aqueous metal ion batteries,which stems from the lack of reasonable configuration and performance optimization of electrode materials.First-row transition metal compounds(FRTMCs),with the advantages of optional voltage ranges(from low to high),adjustable crystal structures(layered and tunnel types with large spacing),and designable morphology(multi-dimensional nanostructures),are widely used to construct high-performance AMIBs.However,no comprehensive review papers were generated to highlight their specific and significant roles in AMIBs.In this review,we first summarize the superiority and characteristics of FRTMCs in AMIBs.Then,we put forward control strategies of FRTMCs from subsurface engineering to inner construction to promote capacitance control and diffusion control energy storage.After that,the electrochemical performance of the FRTMCs regulation strategies in AMIBs is reviewed.Finally,we present potential directions and challenges for further enhancements of FRTMCs in AMIBs.The review aims to provide an in-depth understanding of regulation strategies for enhancing energy storage to build high-performance AMIBs that meet practical applications. | Mengmeng Zhou Xinjun Huang Xiaomeng Tian Baohua Jia Hongge Pan Wenping Sun Qin Zhao Tianyi Ma | 2021 | Journal of Energy Chemistry2021，30，12： | 0 |
| 11 | First Outbreak of Occupational Brucellosis Involving Multiple Clusters--Hubei Province,China,2019显示文摘What is already known on this topic?Human brucellosis,a neglected zoonotic disease,causes more than 500,000 new cases each year globally.The disease is of major public health concern in China,and northern provinces are traditionally endemic areas.What is added by this report?This is the first published outbreak of occupational brucellosis involving multiple clusters in Hubei Province.This investigation characterizes the transmission chain of the outbreak and reveals that provinces south of the Yangtze River are faced with a series of challenges and hurdles to overcome including,but not limited to,health education,law enforcement,and occupational protection.What are the implications for public health practice?In addition to measures aimed at this outbreak,the local agricultural department has issued special notices based on this investigation to adjust and strengthen local eradication program of brucellosis. | Zhong Zhang Yeqing Tong Xinjun Lei Li Liu Zhiqiang Deng Fei Sun Huilai Ma Zhaorui Chang Lijie Zhang Huihui Liu Qi Chen Jianzhong Zheng Haibing Chen Ximei Sun Yang Wu Xuhua Guan | 2020 | China CDC weekly2020，2，39： | 0 |
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