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| 1 | Vitamin D improves inflammatory bowel disease outcomes:Basic science and clinical review显示文摘Vitamin D deficiency is commonly diagnosed among patients with inflammatory bowel disease(IBD).Patients with IBD are at risk of low bone density and increased fractures due to low vitamin D levels,long standing disease,and frequent steroid exposures;as a result,it is well established that vitamin D supplementation in this population is important.There is increasing support for the role of vitamin D in strengthening the innate immune system by acting as an immunomodulator and reducing inflammation in experimental and human IBD.The active form of vitamin D,1,25(OH)D3,acts on T cells to promote T helper(Th)2/regulatory T responses over Th1/Th17 responses;suppresses dendritic cell inflammatory activity;induces antibacterial activity;and regulates cytokine production in favor of an antiinflammatory response.Murine and human IBD studies support a therapeutic role of vitamin D in IBD.Risk factors for vitamin D deficiency in this population include decreased sunlight exposure,disease duration,smoking,and genetics.Vitamin D normalization is associated with reduced risk of relapse,reduced risk of IBD-related surgeries,and improvement in quality of life.Vitamin D is an inexpensive supplement which has been shown to improve IBD outcomes.However,further research is required to determine optimal serum vitamin D levels which will achieve beneficial immune effects,and stronger evidence is needed to support the role of vitamin D in inducing disease response and remission,as well as maintaining this improvement in patients’disease states. | Krista M Reich Richard N Fedorak Karen Madsen Karen I Kroeker | 2014 | World Journal of Gastroenterology2014，20，17： | 34 |
| 2 | 巨噬细胞中缺氧诱导因子1α表达促进动脉粥样硬化的发展显示文摘粥样硬化病变包含缺氧区域,但缺氧病理生理的重要性未知。缺氧诱导因子1a(hypoxia-induciblefactor-1α,HIF-1α)是细胞对低氧反应的关键转录因子。研究人员对HIF-1α在巨噬细胞促进小鼠动脉粥样硬化的生物学效应方面进行调查和验证。 | 刘莉 叶鹏 Aarup A Pedersen TX Junker N Christoffersen C Bartels ED Madsen M Nielsen CH Nielsen LB | 2016 | 中华高血压杂志2016，24，9： | 3 |
| 3 | The Primary Structure and Enzymic Properties of Porcine Prochymosin and Chymosin显示文摘 | HOUEN G MADSEN M T HARLOW K W | 1996 | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY1996，28，： | 1 |
| 4 | Expression of Na^+-K^+-AT- Pase in the brown trout,Salmo trutta: in vivo modulation by hormones and seawater显示文摘 | I MADSEN S S JENSEN M K NHR J | 1995 | Am J Physiol1995，269，： | 1 |
| 5 | Sensitive detection and typing of porcine reproductive and respiratory syndrome virus by RT-PCR amplification of whole viral genes显示文摘 | Olekslewica M B Botner A Madsen K G | 1998 | Vet Microbiology1998，64，1： | 1 |
| 6 | On the definition andmodeling of streamflow drought duration and deficit volume显示文摘 | Tallaksen L M Madsen H Clausen B | 1997 | Hydrological Science Journal1997，42，1： | 1 |
| 7 | Detection and typing of porcinere productive and respiratory syndromevirus by RT PCR amplification of whole vira lgene 显示文摘 | Oleksiewiea M B Botner A Madsen K G | 1998 | J Vet Microbiology1998，64，： | 1 |
| 8 | Serious anaphylactic reactions due to protamine sulfate: a systematic literature review 显示文摘 | Nybo M Madsen JS | 2008 | Basic Clin Pharmacol Toxicol2008，103，2： | 1 |
| 9 | Status and Future Prospects of Lipid-based Particulate Delivery Systems as Vaccine Adjuvants and Their Combination with Immunostimulators显示文摘 | Nordly P Madsen H B Nielsen H M | 2009 | Expert Opinion on Drug Delivery2009，6，7： | 1 |
| 10 | Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study 显示文摘 | Zander M Madsbad S Madsen JL | 2002 | Lancet2002，359，： | 1 |
| 11 | Tranexamic acid given intraop- eratively reduces blood loss after total knee replacement : a randomized controlled study 显示文摘 | Veien M Sorensen JV Madsen F et cd | 2002 | Acta Anaesthesiol Scan2002，46，： | 1 |
| 12 | Cramer-Rao bounds for the estimation of multipath parameters and mobiles positions in asynchronous DS-CDMA systems 显示文摘 | BOTTERON C MADSEN A H FATTOUCHE M | 2004 | IEEE Trans on Signal Processing2004，52，4： | 1 |
| 13 | The potent anti-Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14-kD phospholipase A2显示文摘 | WEINRAUCH Y ELSBACH P MADSEN L M | 1996 | Journal of Clinical Investigation1996，，： | 1 |
| 14 | Reverse transcriptase real - time PCR for detection and quantification of viable Campylobacter jejuni directly from poultry faecal samples 显示文摘 | Bui XT Wolff A Madsen M | 2012 | Res Microbiol2012，163，1： | 1 |
| 15 | Preliminary study on the culture and breeding of Bulinus nyassanus(Mollusca Pulmonata)under laboratory conditions显示文摘 | Lundeba M Likongwe J S Madsen H | 2006 | African Zoology2006，41，1： | 1 |
| 16 | Increased neurogenesia in a modd of electroconvulsive therapy显示文摘 | Madsen T M Tresehow A Bengzon J | 2000 | Biol Psychiatry2000，47，12： | 1 |
| 17 | I solation of Vancomycin Resistant Enterococcus Faeci um From Food显示文摘 | WEGENER H C MADSEN M NIELSEN N | 1997 | Int J Food Microbiol1997，35，： | 1 |
| 18 | Long-term Follow-up of Kidney Donors:a Longitudinal Study 显示文摘 | Saran R Marshall S M Madsen R | 1997 | Nephrol Dial Transplant1997，12，： | 1 |
| 19 | Bakers' Yeast: Improving the D-Stereoselectivity in Reduction of 3-Oxo Esters 显示文摘 | Dahl A C Fjeldberg M Madsen J O | 1999 | Tetrahedron:Asymmetry1999，10，3： | 1 |
| 20 | Randomized controlled trial of genelie amniocenlesis in 4606 low-risk women 显示文摘 | Tabor A Philip J Madsen M | 1986 | Lancet1986，8493，： | 1 |
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