|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Multi-Centre European Experience with Intragastric Balloon in Overweight Populations: 13 Years of Experience显示文摘 | Alfredo Genco Gontrand López-Nava Christian Wahlen Roberta Maselli Massimiliano Cipriano Maria Mara Arenas Sanchez Chantal Jacobs Michele Lorenzo | 2013 | Obesity Surgery2013，，4： | 2 |
| 3 | Feed form and energy concentration of the diet affect growth performance and digestive tract traits of brown-egg laying pullets from hatching to 17 weeks of age显示文摘 | Saldana B Guzmán P Cámara L | 2015 | Poult Sci2015，94，8： | 1 |
| 4 | Sexing of in vitro-produced ovine embryos by duplex PCR 显示文摘 | MARA L PILICHI S SANNA A | 2004 | Mol Reprod Dev2004，69，1： | 1 |
| 5 | Ovarian cortex surrounding benign neoplasms:a histologic study显示文摘 | Maneschi F Marasá L Incandela S | | 0，，2： | 1 |
| 6 | Application of athree-dimensional network model to the coke formation in FAU,MFI and BEA zeolites 显示文摘 | Ca^mara L D T Cerqueira H S Aranda DAG | 2004 | Catalysis Today2004，，98： | 1 |
| 7 | Frequency and fracture morphology of the posteromedial fragment in bicondylar tibial plateau fracture patterns显示文摘 | Barei D P O’Mara T J Taitsman L A | 2008 | Jrthop Trauma2008，22，3： | 1 |
| 8 | Professional confidence in baccalaureate nursing students 显示文摘 | Brown B O' Mara L Hunsberger M | 2003 | Nurse Educ Pract2003，3，3： | 1 |
| 9 | Analysis of Resistant Starch: A Method for Foods and Food Products显示文摘 | Goni I Garcia-Diz L Maras E | 1996 | Food Chemistry1996，56，44： | 1 |
| 10 | Good quality sheep embryos produced by superovulation treatment without the use of progesterone devices显示文摘 | MAYORGA I MARA L SANNA D | 2011 | Theri-ogenology2011，75，9： | 1 |
| 11 | Sexing of in vitro produced ovine embryos by duplex PCR显示文摘 | Mara L Piliclli S Senna A | 2004 | Molecular Reproduetion and Development2004，69，3： | 1 |
| 12 | The functional morphology of juvenile plants tolerant of strong summer drought in shaded forest understories in Southern Spain显示文摘 | SACK L GRUBB P J MARA(NO) T | 2003 | Plant Ecology2003，168，： | 1 |
| 13 | Frequency and ftacture morphology of the posteromendial fragment in bicondylar tibial plateau frcture patterns显示文摘 | Barei DP O′Mara TJ Taitsman L A | | 0，，03： | 1 |
| 14 | Dietary fatty acid intake and prostate cancer survival in orebro County, Sweden显示文摘 | Epstein Mara M Kasperzyk Julie L Mucci Lorelei A | 2012 | American journal of epidemiology2012，176，3： | 1 |
| 15 | Mycoplasma Suis in Naturally Infected Pigs: An Ultrastruetural and Morphomettic Study 显示文摘 | Enrique L Portiansky Mara A | 2004 | Pesq Vet Bras2004，24，1： | 1 |
| 16 | Assessment of synthetic chimeric multiple antigenic peptides for diagnosis of GB virus C infection显示文摘 | G(O)MARA M J FERN(A)NDEZ L P(E)REZ T | 2010 | Anal Biochem2010，396，1： | 1 |
| 17 | Frequency and fracture morphology of lh posleromedial fi'agment in bicondylar tibial plateau fracture pallerns显示文摘 | Barei D P 0' Mara T J Taitsman L A at al | 2008 | J Orlhop Trauma2008，22，2： | 1 |
| 18 | Contextual Connections within Puns:Effects on Perceived Humor and Memory显示文摘 | Louis G Lippman Mara L Dunn | 2000 | The Journal of General Psychology2000，127，： | 1 |
| 19 | Influence of net energy content of the diets on productive performance and carcass merit of gilts,boars and immunocastrated males slaughtered at 120 kg BW显示文摘 | CáMARA L BERROCOSO J D SáNCHEZ J L | 2014 | Meat Science2014，98，4： | 1 |
| 20 | High levels of low energy reporting on 24-hour recalls and three questionnaires in an elderly low-socioeconomic status population 显示文摘 | JANET A T MARA Z V SHANNON L S | 2007 | J Nutr2007，137，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员