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| 1 | An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure显示文摘Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy which causes multiorgan failure with an extremely high mortality rate, even if intensive care is provided. Management of severe AHF continues to be one of the most challenging problems in clinical medicine. Liver transplantation has been shown to be the most effective therapy, but the procedure is limited by shortage of donor organs. Although a number of clinical trials testing different liver assist devices are under way, these systems alone have no significant effect on patient survival and are only regarded as a useful approach to bridge patients with AHF to liver transplantation. As a result, reproducible experimental animal models resembling the clinical conditions are still needed. The three main approaches used to create an animal model for AHF are: surgical procedures, toxic liver injury and infective procedures. Most common models are based on surgical techniques (total/partial hepatectomy, complete/transient devascularization) or the use of hepatotoxic drugs (acetaminophen, galactosamine, thioacetamide, and others), and very few satisfactory viral models are available. We have recently developed a viral model of AHF by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease. This model displays biochemical and histological characteristics, and clinical features that resemble those in human AHF. In the present article an overview is given of the most widely used animal models of AHF, and their main advantages and disadvantages are reviewed. | María Jesús Tuón Marcelino Alvarez Jesús M Culebras Javier González-Gallego | 2009 | World Journal of Gastroenterology2009，15，25： | 29 |
| 2 | Cervical spinal cord injury complicating ankylosing spondylitis 显示文摘 | Foo D Sarkarati M Marcelino V | 1985 | Paraplegia1985，23，6： | 1 |
| 3 | Effects of tungsten carbide thermal spray coating by HP/HVOF and hard chromium electroplating on AISI 4340 high strength steel显示文摘 | Renato C S Ivancy M M | 2001 | Surface and Coatings Technology2001，138，： | 1 |
| 4 | Achieving the nitrite pathway using aeration phase length control and step-feed in an SBR removing nutrients from abattoir wastewater显示文摘 | LEMAIRE R MARCELINO M YUAN Zhi-guo | 2008 | Biotechnology and Bioengineering2008，100，6： | 1 |
| 5 | Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by reconditioning PCR显示文摘 | Thompson J Marcelino L Polz M | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 6 | Heteroduplexes in mixed-template amplifications:formation,consequence and elimination by 'reconditioning PCR'显示文摘 | Thompson J R Marcelino L A Polz M F | 2000 | Nucleic Acids Res2000，30，： | 1 |
| 7 | Compensatory responses of an arid land crucifer, Chorispora tenella (Brassicaceae), to experimental flower removal显示文摘 | Gómez José M Fuentes Marcelino | 2001 | Journal of Arid Environments2001，，10： | 1 |
| 8 | Transient numerical study of the effect of ambient temperature on 2 - D cereal grain storage in cy- lindrical silos 显示文摘 | Marcelino Carrera - Roddguez Gloria M Martinez - Gonz61ez | 2011 | Journal of Stored Products Research2011，47，： | 1 |
| 9 | Heteroduplexes in mixedtemplate amplifications :formation ,consequence and elimination by 'reconditioning PCR'显示文摘 | THOMPSON JR MARCELINO L A POLZ M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 10 | Cervical spinal cord injury complicating ankylosing spondylitis显示文摘 | Foo D Sarkarati M Marcelino V | 1985 | Paraplegia1985，23，6： | 1 |
| 11 | The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth显示文摘 | Rhee DK Marcelino J Baker M | | 0，，3： | 1 |
| 12 | Effects of tungsten carbide thermal spray coating by HP/HVOF and hard chromium electroplating on AISI 4340 high strength steel显示文摘 | Marcelino P N Renato C S Ivancy M M | 2001 | Surface and Coatings Technology2001，138，： | 1 |
| 13 | Heteroduplexes in mixed-template amplification: formation, consequence and elimination by 'reconditioning PCR'显示文摘 | Thompson J R Marcelino L A Polz M F | 2002 | Nucleic Acids Res2002，30，： | 1 |
| 14 | Cervical spinal cord injury compli- cating ankylosing spondylitis显示文摘 | Foo D Sarkarati M Marcelino V | 1985 | Paraplegia1985，23，6： | 1 |
| 15 | A rare case of hyperandrogenism:bilateral Leydig cell tumor of the ovary显示文摘 | Marcelino M Nobre E Conceicao J | | 0，，01： | 1 |
| 16 | Diversity and dynamics of a North Atlantic coastal Vibrio community 显示文摘 | Thompson J R Randa M A Marcelino L A etal | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 17 | A two-sludge system for simultaneous biological C, N and P removal via the nitrite pathway 显示文摘 | Marcelino M Wallaert D Guisasola A | 2011 | Water science and technology2011，64，5： | 1 |
| 18 | Achieving the nitrite pathway using aeration phase length control and step-feed in an SBR removing nutrients from abattoir wastewater显示文摘 | LEMAIRE R MARCELINO M YUAN Z G | 2008 | Biotechnology and Bioengineering2008，100，6： | 1 |
| 19 | Effect of WC thermal spray coating by HP/HVOF and hard chromium electroplating on AIS14340 high strength steel显示文摘 | Marcelino P+ Renato C Souza+ lvancy M Miguel | 2001 | Surface and coating technology2001，，138： | 1 |
| 20 | Heteroduplexes in mixed-template amplifications:formation,consequence and elimination by ‘econditioning PCR'显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
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