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| 1 | K-ras^G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis显示文摘增加的氧气的 glycolysis 和氧化应力是癌症房间新陈代谢的重要特征,但是内在的生物化学、分子的机制留下逃犯。用四圜素可诱导的模型,我们显示出 K 地岬 G12V 原因 mitochondrial 机能障碍,导致反应的氧的减少的呼吸,提高的 glycolysis,和增加的产生种类。K 地岬蛋白质与线粒体被联系,并且导致呼吸的链建筑群的快速的抑制 -- 我和在由影响 cyclosporin 敏感的渗透的 mitochondrial transmembrane 潜力的减少转移毛孔。而且, K 地岬 在 vitro 的 G12V 表示提高转变房间的能力允许新陈代谢的改编到高 glycolytic 新陈代谢在 vivo 形成肿瘤。我们的学习建议 mitochondrial 机能障碍的那正式就职是由 K 地岬 G12V 在癌症房间引起新陈代谢的变化和 ROS 应力,并且支持肿瘤开发。 | Yumin Hu Weiqin Lu Gang Chen Peng Wang Zhao Chen Yan Zhou Marcia Ogasawara Dunyaporn Trachootham Li Feng Helene Pelicano Paul J Chiao Michael J Keating Guillermo Garcia-Manero Peng Huang | 2012 | Cell Research2012，22，2： | 6 |
| 2 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 3 | Identity status change during adolescence and young adulthood:a meta-analysis显示文摘 | Kroger J Martinussen M Marcia J E | 2009 | Journal of Adolescence2009，33，5： | 1 |
| 4 | Development and validation of ego identity status显示文摘 | Marcia J E | | 0，，05： | 1 |
| 5 | Ego-identity status in college women显示文摘 | Marcia J E Friedman M F | 1970 | Journal of Personality1970，38，： | 1 |
| 6 | Analysis of the growth of molecular sieve zeolite NaA in a batch precipitation system显示文摘 | ROBERT W T MARCIA J H | 1982 | J Crystal Growth1982，56，3： | 1 |
| 7 | Effect of pretreatmentwith microwaves on mechanical extraction yield and quality of vegetable oil from Chilean hazelnuts (Gevunia avellana Mol) 显示文摘 | UQUICHE E MARCIA J ORTIZ J | 2008 | Innovative Food Science and Emerging Technol- ogies2008，，9： | 1 |
| 8 | Development and validation of ego-identity status显示文摘 | Marcia J | 1966 | Journal of Personality and Social Psychology1966，15，3： | 1 |
| 9 | Extraction of ginger (Zingiber officinale Roscoe) oleo- resin with CO2 and co-solvents: a study of the antioxidant action of the extracts 显示文摘 | Zancan Kelly C Marques Marcia O M Petenate Ademir J | 2002 | The Journal of Supercritical Fluids2002，24，1： | 1 |
| 10 | Nutrient cycling in age sequences of two Eucalyptus plantation species显示文摘 | Turner J Marcia J L | 2008 | Forest Ecology and Management2008，255，56： | 1 |
| 11 | Effect of pretreatment with microwaves on mechanical extraction yield and quality of vegetable oil from Chilean hazelnuts ( Gevuina avellana Mol) 显示文摘 | Edgar U Marcia J Jaime O | 2008 | Innovative Food Science and Emerging Technologies2008，9，4： | 1 |
| 12 | Com- pressed sensing for practical optical imaging sys terns: a tutorial 显示文摘 | WILLETT R MARCIA R NICHOLS J | 2011 | Optical Engineering2011，50，7： | 1 |
| 13 | Olympulse VI: A Post-Event Assessment of Resident Reaction to the Olym- pic Winter Games显示文摘 | Brent Ritchie J R Marcia Lyons | 1990 | Journal of Travel Research1990，，28： | 1 |
| 14 | Development and validation of ego identity status显示文摘 | Marcia J E | | J PersonSoc Psych0，3，： | 1 |
| 15 | Definition, diagnosis, and forensic implications of postconcussional syndrome显示文摘 | RYAN C W RICHRD C W MARCIA J | 2005 | Psychosomatics2005，46，： | 1 |
| 16 | Methyl tert-butyl ether biodegradation by microbial consortia obtained from soil samples of gasoline-polluted sites in Mexico显示文摘 | Marcia M Elia V Janet J | 2004 | Biotechnology Letters2004，26，3： | 1 |
| 17 | ?Emergent anxiety after antidepressant initiation:a retrospective cohort study of Veterans Affairs Health System patients with depression显示文摘 | Zhiguo Li Paul N Pfeiffer Katherine J Hoggatt Kara Zivin Karen Downing Dara Ganoczy Marcia Valenstein | 2011 | Clinical therapeutics2011，33，12： | 1 |
| 18 | The invisible substrate of information science 显示文摘 | Bates Marcia J | 1999 | Journal of the American Society for Information Science1999，50，12： | 1 |
| 19 | A broadband model of sandy ocean sediments:Biot stoll with contact squirt flow and shear drag显示文摘 | Nicholas P C Marcia J I | 2004 | The Journal of the Acoustical Society of Ameriea2004，116，4： | 1 |
| 20 | Identity in adolescence显示文摘 | Marcia J E | 1980 | Handbook of adolescent psychology1980，9，： | 1 |
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