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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | T-regulatory lymphocytes in peripheral blood of gastric and colorectal cancer patients显示文摘AIM: To assess the absolute number of T-regulatory cells (Tregs; CD4+CD25+Foxp3+) in the peripheral blood of gastric and colorectal cancer patients. METHODS: We enrolled 70 cancer patients (33 gastric cancer, 37 colorectal cancer) and 17 healthy volunteers. The CD3+CD4+ lymphocytes and CD4+CD25+Foxp3+ Tregs in the peripheral blood were analyzed with flow cytometry. The absolute numbers of Tregs were calculated based on the CD4+CD25+Foxp3+ cells percent-age of CD3+CD4+ cells and the absolute numbers of CD3+CD4+ cells per microliter. RESULTS: The mean number of CD4+CD25+Foxp3+ cells per microliter in colorectal cancer patients was 15.7 (SD: 21.8), for gastric cancer patients 12.2 (SD: 14.3), and for controls 17.5 (SD: 11.4). The absolute number of Tregs was significantly lower in gastric cancer patients than in controls (P = 0.026). There was no statistically significant difference for gastric vs colorectal cancer or colorectal cancer vs controls. The absolute number of Tregs was also significantly depressed in N+ vs Ncancer patients [22.0 (27.7) vs 10.1 (9.0), P = 0.013], and in the subgroup of gastric cancer patients [30.3 (27.6) vs 9.6 (8.0), P = 0.003]. No statistical difference was observed in the proportion of Tregs in the CD4+ population between the groups. CONCLUSION: The absolute number of Tregs in peripheral blood of gastric cancer but not colorectal cancer patients was significantly decreased in comparison with that in healthy controls. | Antoni M Szczepanik Maciej Siedlar Marek Sierzega Dominika Goroszeniuk Karolina Bukowska-Strakova Antoni Czupryna Jan Kulig | 2011 | World Journal of Gastroenterology2011，17，3： | 5 |
| 3 | Secondary pancreatic involvement by a diffuse large B-cell lymphoma presenting as acute pancreatitis显示文摘Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma. More than 50% of patients have some site of extra-nodal involvement at diagnosis, including the gastrointestinal tract and bone marrow. However, a diffuse large B-cell lymphoma presenting as acute pancreatitis is rare. A 57-year-old female presented with abdominal pain and matted lymph nodes in her axilla. She was admitted with a diagnosis of acute pancreatitis. Abdominal computed tomography (CT) scan showed diffusely enlarged pancreas due to infiltrative neoplasm and peripancreatic lymphadenopathy. Biopsy of the axillary mass revealed a large B-cell lymphoma. The patient was classified as stage Ⅳ, based on the Ann Arbor Classification, and as having a high-risk lymphoma, based on the International Prognostic Index. She was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone). Within a week after chemotherapy, the patient’s abdominal pain resolved. Follow-up CT scan of the abdomen revealed a marked decrease in the size of the pancreas and peripancreatic lymphadenopathy. A literature search revealed only seven cases of primary involvement of the pancreas in B-cell lymphoma presenting as acute pancreatitis. However, only one case of secondary pancreatic involvement by B-cell lymphoma presenting as acute pancreatitis has been published. Our case appears to be the second report of such a manifestation. Both cases responded well to chemotherapy. | M Wasif Saif Sapna Khubchandani Marek Walczak | 2007 | World Journal of Gastroenterology2007，13，36： | 4 |
| 4 | Heart rate deceleration runs for postinfarction risk prediction显示文摘 | Przemyslaw Guzik Jaroslaw Piskorski Petra Barthel Axel Bauer Alexander Müller Nadine Junk Kurt Ulm Marek Malik Georg Schmidt | 2012 | Journal of Electrocardiology2012，，1： | 3 |
| 5 | Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study显示文摘 | Axel Bauer Jan W Kantelhardt Petra Barthel Raphael Schneider Timo M?kikallio Kurt Ulm Katerina Hnatkova Albert Sch?mig Heikki Huikuri Armin Bunde Marek Malik Georg Schmidt | 2006 | The Lancet2006，，9523： | 3 |
| 6 | Effect of Copper Content and Heat Treatment on the Stress Corrosion Characteristics of Al-6Zn- 2Mg-XCu Alloys显示文摘 | Sarkar B Marek M Starke E A Jr | 1981 | Metallurgical TransactionsA1981，12，11： | 1 |
| 7 | Microstructure, toughness and stress corrosion cracking behavior of aluminum alloy 2020显示文摘 | R1NKER J MAREK M SANDERS T | 1984 | Materials Science and Engineering1984，64，2： | 1 |
| 8 | influence of gender on the Course of neuromuscular block following a single bolus dose of cisatracuriam or rocuronium显示文摘 | Adamus M Gabrhelik T Marek O | 2008 | Eur J Anesthesiol2008，25，7： | 1 |
| 9 | Heart rate variability: standards of measurement physiological interpretation and clinical use 显示文摘 | Marek M | 1996 | Circulation1996，93，： | 1 |
| 10 | Comparison of design and operation strategies for temperature control during selective catalytic reduction of NOx 显示文摘 | Jirat J Stepanek F Marek M | 2001 | Chem Eng Technol2001，24，： | 1 |
| 11 | Seasonal changes of photosynthetic assimilation of Norway spruce under the impact of enhanced UV-B radiation显示文摘 | Sprtova M Marek M V Nedbal L | 1999 | Plant Science1999，142，： | 1 |
| 12 | Comparison of design and operation strategies for temperature control during selective catalytic reduction of NOx显示文摘 | Stepanek F Marek M Kubicek M | 2001 | Chemical Engineering and Technology2001，24，1： | 1 |
| 13 | Silica recovery from waste obtained in hydrofluoric acid and aluminum fluoride produc- tion from fluosilicic acid显示文摘 | Andrzej K Bozena R Marek M | 1996 | Journal of Hazardous Materials1996，48，： | 1 |
| 14 | Heart rate variability:standards of measurement,physiological interpretation,and clinical use显示文摘 | Marek M | 1996 | Circulation1996，93，： | 1 |
| 15 | Sleep apnea syndrome and snoring in patients with hypothyroidism with relation to overweight显示文摘 | Misiolek M Marek B Namyslowski G | | 0，，： | 1 |
| 16 | Evaluating a museum as a tourist pro-duct using the servqual method显示文摘 | | 2005 | Museum Management and Quratorship2005，20，： | 1 |
| 17 | Silieareeovery from waste obtained in hydrofluoric acid and aluminum fluoride production from fluosilicie acid显示文摘 | Andrzej K Bozena R Marek M | 1996 | Journal of Hazardous Materials1996，48，： | 1 |
| 18 | The Shark-search algorithm - an application: Tailored Web site mapping显示文摘 | HERSEOVICI M JACOV M MAREK Y S | 1998 | Computer Networks and ISDN Systems1998，30，17： | 1 |
| 19 | The role of nireic oxide in portal hypertensive systemic and portal vascular pathology 显示文摘 | Harthb M Michielsen PP Dxiurkowska - Marek A | 1997 | Acta Gastroenterol Velg1997，，60： | 1 |
| 20 | 显示文摘 | Marek P Jan M Benediete V | 2006 | Journal of Magnetism and Magnetic Materials2006，，： | 1 |
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