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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Genetic algorithms for optimal placement of phasor measurement units in electrical networks 显示文摘 | MARIN F J GARCIA L | 2003 | Eleetronies Letters2003，39，19： | 1 |
| 3 | Premature myocardial infarction: clinical profile and angiographic findings 显示文摘 | Pineda J Marin F | 2008 | Int J Cardiol2008，126，1： | 1 |
| 4 | Reforming of C7 hydrocarbons on sulfided commercial Pt/Al2O3 catalyst显示文摘 | Van Trimpont P A Marin G B Froment G F | 1988 | Ind Eng Chem Res1988，27，1： | 1 |
| 5 | High sensitivity cardiac troponin T and interleukin-6 predict adverse cardiovascular events and mortal- ity in antieoagulated patients with atrial fibrillation 显示文摘 | Roldan V Marin F Diaz J | 2012 | J Thromb Haemost2012，10，8： | 1 |
| 6 | Phosphorus clusters:synthesis in the gas-phase and possible cagelike and chain structures显示文摘 | Bulgakov A V Bobrenok O F Kosyakov V I Pzerov I Marine W Hed~n M Rohmund F Campbell E E B | | 0，，： | 1 |
| 7 | Activated Carbons from KOH-activa- tion of Argan (Argania Spinosa) Seed Shells as Supercapaci- tor Electrodes显示文摘 | ELMOUWAHIDI A ZAPATA-BENABITHE Z CARRAS- CO- MARIN F | 2012 | Bioresource Technology2012，111，0： | 1 |
| 8 | Pharmaco- genetics in cardiovascular antithrombotic therapy 显示文摘 | MARIN F ROLD6JN V GONZ6LEZ-CONEJERO R | 2005 | Curr Med Chem Cardiovasc Hematol Agents2005，3，4： | 1 |
| 9 | Behavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent rats显示文摘 | CRUZ F C MARIN M T LE ~O R M | 2012 | International Journal of Developmental Neuroscience2012，30，1： | 1 |
| 10 | Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy 显示文摘 | Roldm V Marin F Gimeno J R | 2008 | Am Heart J2008，156，1： | 1 |
| 11 | Evolution of nacre: Biochemistry and proteomics of the shell organic matrix of the cephalopod Nautilus macromphalus显示文摘 | MARIE B MARIN F MARIE A | 2009 | Chembiochem2009，10，： | 1 |
| 12 | Varicella vaccine effectiveness in the US vaccination program:a review显示文摘 | SEWARD J F MARIN M VASQUEZ M | 2008 | J Infect Dis2008，197，2： | 1 |
| 13 | Review on thermal energy storage with phase change:materials,heat transfer analysis and applications显示文摘 | MARIN J M LUISA F | 2003 | Applied Thermal Engineering2003，23，： | 1 |
| 14 | Statins and postoperative risk of atrial fibrillation following coronary artery bypass grafting 显示文摘 | Marin F Pascual DA Roldan V | 2006 | Am J Cardiol2006，97，1： | 1 |
| 15 | Comparative effects of teriparatide and risedronate in glucocorticoid-induced osteoporosis in men : 18-month results of the Euro GIOPs trial 显示文摘 | Gltler CC Marin F Ringe JD | 2013 | J Bone Miner Res2013，28，6： | 1 |
| 16 | Effects of two years of daily teriparatide treatment on bone mineral density in postmenopausal women with severe osteoporosis with and without prior antiresorptive treatment显示文摘 | Obermayer-Pietsch BM Marin F Mc Closky EV | 2008 | J Bone Miner Res2008，，10： | 1 |
| 17 | Teriparatide for osteoporosis: importance of the full course 显示文摘 | LINDSAY R KREGE J H MARIN F | 2016 | Osteopo- ros lnt2016，27，8： | 1 |
| 18 | Electro-oxidation of ammonia in wastewater显示文摘 | Mariner L Lectz F B | 1978 | J Appl Electrochem1978，8，： | 1 |
| 19 | Mechanical alloying of Cu-Mo powder mixtures and thermodynamics study of solubility 显示文摘 | MARTINEZ V P AGUILAR C MARIN J ORDONEZ S CASTRO F | 2007 | Materials Letters2007，61，45： | 1 |
| 20 | Antithrombotic management and type of stent in atrial fibrillation patienls un- dergoing percutaneous coronary intervention 显示文摘 | Ruiz-Nodar J M Marin F IAp G Y H | 2013 | Rev Esp Cardiol2013，66，1： | 1 |
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