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| 1 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 2 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | The presence of ANP in rat peritoneal mast cells显示文摘Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient. By Western blotting, two ANP-immunoreactive proteins of molecular masses of 2.5 kDa and 16.9 kDa were detected in lysates from these mast cells. Electron microscope immunogold labeling has revealed the presence of ANP-immunoreactive material in storage, secreting and released granules of mast cells. Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP. These both peptides are located in mast cell secretory granules and released by mechanism of degranulation. It is discussed that many mast cell functions might be due to production of natriuretic peptides by these cells. | Marina G MARTYNOVA Olga A BYSTROVA Olga M MOISEEVA Anton L EVDONIN Kirill A KONDRATOV Natalja D MEDVEDEVA | 2005 | Cell Research2005，15，10： | 3 |
| 4 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 5 | Synthesis, characterization and photocatalytic activity of different metal-dopedtitania systems 显示文摘 | Colmenares J C Aramendia M A Marinas A | 2006 | Applied Catalysis a-General2006，306，： | 1 |
| 6 | A topology control approach for utilizing multiple channels in multi-radio wireless Mesh networks显示文摘 | MARINA M K DAS S R SUBRAMANIAN A P | 2010 | Computer Networks2010，54，2： | 1 |
| 7 | Inactivation of Cryptosporidium parvum oocysts with ozone and monochlo- famine at low temperature显示文摘 | Driedger A M Rennecker J L Marinas B J | 2001 | Water Research2001，35，1： | 1 |
| 8 | Virgin coconut oi1:emerging functional food oil显示文摘 | Marina A M Man Y B C Amin I | 2009 | Trends in Food Science&Technology2009，20，10： | 1 |
| 9 | Inactivation of Bacillus subtilis spores with ozone and monochloramine显示文摘 | Larson M A Marinas B J | 2003 | Water Research2003，37，4： | 1 |
| 10 | Recent advances in the analysis of antibiotics by CE and CEC显示文摘 | CASTRO-PUYANA M CREGO A L MARINA M L | 2008 | Electrophorcsis2008，29，1： | 1 |
| 11 | Chemical properties of virgin coconut oil显示文摘 | Marina A M et a1 | 2009 | Journal of the American Oil Chemists’Society2009，86，4： | 1 |
| 12 | Organochlorine and heavy metal residues in the water/sediment system of the Southeast Regional Park in Madrid, Spain显示文摘 | Fernandez M Cuesta S Jimenez O Garcia M A Hernandez L M Marina M L Gonzalez M J | 2000 | Chemosphere2000，41，： | 1 |
| 13 | A capillary electrophoresis-tandem mass spectrometry methodology for the determination of non-protein amino acids in vegetable oils as novel markers for the detection of adulterations in olive oils显示文摘 | SANCHEZ-HEMfi NDEZ L MARINA M L CREGO A L | 2011 | Journal of Chromatography A2011，1218，30： | 1 |
| 14 | New formulation and a branch-and-cut algorithm for the multiple allocation p- hub median problem显示文摘 | GARC LANDETE M MARiNA | 2012 | European Journal of Operational2012，220，1： | 1 |
| 15 | Chemical properties of virgin coconut oil显示文摘 | MARINA A M CHE MAN Y B NAZIMAH S A H | 2009 | J Am Oil Chem Soc2009，86，4： | 1 |
| 16 | A topology con- trol approach for utilizing multiple channels in multi-radio wireless mesh networks显示文摘 | MARINA M K DAS S R SUBRAMANIAN A P | 2010 | Computer Networks2010，54，2： | 1 |
| 17 | Synthesis of 6-aminopropyl-6H-indolo quinoxaline derivatives显示文摘 | Marina 0 S Nina A K Alexandr V M el a1 | 2012 | ] Heterocyclic Chern2012，49，3： | 1 |
| 18 | Photocatalytic degradation of herbicide fluroxypyrin aqueous suspension of TiO2 显示文摘 | Aramedia M A Marinas A Marinas J M | 2005 | Sci & Direct Catalysis Today2005，24，101： | 1 |
| 19 | Incidence and risk factors for stroke in type2 diabetic patients: The DAl Study 显示文摘 | Carlo B G Angelo A Marina M | 2007 | Stroke2007，38，4： | 1 |
| 20 | Acidity and catalytic activity of AlPO4-B2O3 and Al2O3-B2O3 (5-30% B2O3) systems prepared by impregnation显示文摘 | BAUTISTA F M CAMPELO J M GARCIA A LUNA D MARINAS J M MORENO M C ROMERO A A | 1998 | Appl Catal A: Gen1998，170，1： | 1 |
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