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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 3 | CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome 显示文摘 | Mari F Azimonti S Bertani I | 2005 | Hum Mol Genet2005，14，： | 1 |
| 4 | COL4A3/ COL4A4 mutations:from familial hematuria to autosomal dominant or recessive Alport syndrome显示文摘 | Longo I Porcedda P Mari F | 2002 | Kidney Int2002，61，： | 1 |
| 5 | Design of a PZT Bimorph Actuator Using a meta - model based Approach 显示文摘 | DAVID J C MARY I F TIMOTHY W S | 2002 | Transactions of the ASME2002，124，6： | 1 |
| 6 | Fatal Mycobacterium peregrinum pneumonia in re fractory polymyositis treated with infliximab 显示文摘 | Marie I Heliot P Roussel F | 2005 | Rheumatology (Ox ford)2005，44，9： | 1 |
| 7 | COIAA3/COIAA4 mutations: from familial hematuria to autosomal-dominant or recessive Alport syndrome 显示文摘 | Longo I Porcedda P Mari F | 2002 | Kidney Int2002，61，6： | 1 |
| 8 | Autosomal recessive Alport syndrome: an in-depth clinical and molecular analysis of five families 显示文摘 | Longo I Scala E Mari F | 2006 | Nephrol Dial Transplant2006，21，3： | 1 |
| 9 | Kluve-Bucy syndrome in herpetic meningoencephalitis显示文摘 | Rashilas F Mari I | 2001 | Presse Med2001，30，3： | 1 |
| 10 | Monitoring the expression profiles of 7 000 Arabidopsis genes under drought,cold and high-salinity stresses using a full-lenghth cDNA microarray显示文摘 | Motoaki S Mari N Junko I Tokihiko N,Miki F,Youko O,Asako K,Maiko N,Akiko E,Tetsuya S,Masakazu S,Kenji A,Teruaki T,Kazuko Y S,Piero C,Jun K,Yoshihide H,Kazuo S | | 0，，： | 1 |
| 11 | COL4A3/COL4A4 mutations: fromfamilial hematuria to autosomal - dominant or recessive Alport syndrome显示文摘 | Longo I Porcedda P Mari F | 2002 | Kidney Int2002，61，6： | 1 |
| 12 | Infectious complications in polymyositis and dermatomyositis:a series of 279 patients显示文摘 | Marie I Menard J F Hachulla E | | 0，，01： | 1 |
| 13 | Relating fresh concrete viscosity measurements from different rheometers显示文摘 | FERRAR I F MARYS N S | 2003 | National Institute of Standards and Technology2003，108，3： | 1 |
| 14 | COL4A3/COL4A4 mutations : From familial hematuria to autosomal - dominant or reeessive Alport syndrome 显示文摘 | Longo I Porcedda P Mari F | 2002 | Kidney Int2002，61，6： | 1 |
| 15 | Control of postprandial hyperglycemia optimal use of short-acting insulin secretagogues 显示文摘 | Carroll Ahmad I Katrina R Mark R Burge | 2002 | Diabetes Care2002，25，： | 1 |
| 16 | Treating hypothyroidism improves endothelial function显示文摘 | Georgios I Papaioannou Marie Lagasse Jeffrey F Mather Paul D Thompson | 2004 | Metabolism2004，，3： | 1 |
| 17 | COL4A3/COL4A4 mutations:from familial hematuria to autosomal-dominant or recessive Alport syndrome显示文摘 | Longo I Porcedda P Mari F | 2002 | Kidney Int2002，61，6： | 1 |
| 18 | Kluver-Bucy syndrome in herpetic meningoencephalitis显示文摘 | Bonno S Rashilas F Mari I | 2001 | Presse Med2001，30，3： | 1 |
| 19 | COL4A3/COL4A4mutations:from familial hematuria to autosomaldom inant or recessive Alport syndrome显示文摘 | Longo I Porcedda P Mari F | 2002 | Kidney Int2002，61，： | 1 |
| 20 | Comparison of PCR-ELISAand Real-Time PCR for invasive aspergillosis diagnosis in pa-tients with hematological malignancies显示文摘 | Hadrich I Mary C Makni F | 2011 | Med Mycol2011，49，5： | 1 |
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