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| 1 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | Numerical and experimental analysis of high strength concrete beams, reinforced with high yield steel bars submitted to flexure 显示文摘 | Lorrain M Maurel O Boukari S | 1999 | Materials and Structures1999，32，224： | 1 |
| 3 | A measure of the Geographic Concentration in French Manufacturing Industries显示文摘 | Maurel F Sé dillot B | 1999 | Regional Science and Urban Economics1999，29，5： | 1 |
| 4 | Myristoylation signal transfer from the large to the middle or the small HBV envelope protein leads to a loss of HDV particles in- fectivity显示文摘 | Abou-Jaoude G Molina S Maurel P | 2007 | Virolo:2007，，1： | 1 |
| 5 | Photoacti-vatable and photoconvertible fluorescent probes for proteinlabeling显示文摘 | Maurel D Banala S Laroche T Johnsson K | 2010 | ACS Chemical Biology2010，5，5： | 1 |
| 6 | Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27显示文摘 | LANNEAU D DE THONEL A MAUREL S | 2007 | Prion2007，1，1： | 1 |
| 7 | Plant aquaporins:their molecular biology, biophysics and significance for plant water relations显示文摘 | Tyerman S D Bohnbert H 3 Maurel C | 1999 | 3 Exp Bot1999，50，： | 1 |
| 8 | Plant aquaporins: their molecular biology, biophysics and significance for plant water relations 显示文摘 | Tyerman S D Bohnert H J Maurel C | 1999 | Journal of Experimental Botany1999，50，： | 1 |
| 9 | Plant aquaporins:their molecular biology,biophysics and significance for plant water relations显示文摘 | TYERMAN S D BOHNERT H J MAUREL C STEUDLE E SMITH J A C | 1999 | Journal of Experimental Botany1999，50，： | 1 |
| 10 | Plant aquaporins: Their molecular biology, biophysics and significance for plant water relations显示文摘 | TYERMAN S D BOHNERT H J MAUREL C STEUDLE E SMITH J A C | 1999 | Journal of Experimental Botany1999，50，： | 1 |
| 11 | Plant aquaporins: their molecular biology, biophysics and significance for plant water relations显示文摘 | Tyerman S D Bohnert H J Maurel C | 1999 | Journal of Experimental Botany1999，，50： | 1 |
| 12 | Apoptosis versus cell differentiation : role of heat shock proteins HSP90, HSP70 and HSP27 显示文摘 | Lanneau D de Thonel A Maurel S | 2007 | Prion2007，1，1： | 1 |
| 13 | Plant aquaporins: their molecular biology, biophysics and significance for plant water relations显示文摘 | Tyerman S D Bohnert H J Maurel C | 1999 | J Exp Bot1999，25，： | 1 |
| 14 | Plant aqua-porins:their molecular biology,biophysics and significance forplant water relations显示文摘 | TYERMAN S D BOHNERT H J MAUREL C | 1999 | J Exp Bot1999，50，： | 1 |
| 15 | Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit显示文摘 | MAUREL D ETZOL S | 2004 | J Biol Chem2004，279，15： | 1 |
| 16 | Hexachlorobenzene,a dioxin-like compound,disrupts auditory function in rat显示文摘 | Hadjab S Maurel D Cazals Y | 2004 | Hearing Research2004，191，： | 1 |
| 17 | Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27 显示文摘 | Lanneau D de Thonel A Maurel S | 2007 | Prion2007，1，1： | 1 |
| 18 | Ncctin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination 显示文摘 | Maurel P Einheber S Galinska J | 2007 | J Cell Biol2007，178，5： | 1 |
| 19 | A functional screening iden- tifies five microRNAs controlling glypican-3: role of microRNA- 1271 down-regulation in hepatocellular carcinoma 显示文摘 | Maurel M Jalvy S Ladeiro Y | 2013 | Hepatolo- gy2013，57，1： | 1 |
| 20 | Numerical and experimental analysis of high strength concrete beams reinforced with high yield steel bars submitted to flexure 显示文摘 | Lorrain M Maurel O Boukari S | 1999 | Materials and Structures1999，32，12： | 1 |
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