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| 1 | Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications显示文摘Hepatocellular carcinoma(HCC) is the fifth most common cancer and is the second leading cause of cancer death. Since the diagnosis of HCC is difficult, in many cases patients with HCC are diagnosed advanced stage of development. Hepatocyte growth factor(HGF)/c-mesenchymal-epithelial transition receptor(c-Met) axis is a key signaling pathway in HCC, either via canonical or non-canonical pathways. Available treatments against HCC based upon HGF/c-Met inhibition can increase patient lifespan, but do not reach the expected therapeutic benefits. In HCC, c-Met monomers can bind other receptor monomers, activating several noncanonical signaling pathways, leading to increased cell proliferation, invasion, motility, and drug resistance. All of these processes are enhanced by the tumor microenvironment, with stromal cells contributing to boost tumor progression through oxidative stress, angiogenesis, lymphangiogenesis, inflammation, and fibrosis. Novel treatments against HCC are being explored to modulate other targets such as microR NAs, methyltransferases, and acetyltransferases, which are all involved in the regulation of gene expression in cancer. This review compiles basic knowledge regarding signaling pathways in HCC, and compounds already used or showing potential to be used in clinical trials. | Javier A García-Vilas Miguelángel Medina | 2018 | World Journal of Gastroenterology2018，24，33： | 10 |
| 2 | Imaging of the temporomandibular joint: An update显示文摘Imaging of the temporomandibular joint(TMJ) is continuously evolving with advancement of imaging technologies. Many different imaging modalities are currently used to evaluate the TMJ. Magnetic resonance imaging is commonly used for evaluation of the TMJ due to its superior contrast resolution and its ability to acquire dynamic imaging for demonstration of the functionality of the joint. Computed tomography and ultrasound imaging have specific indication in imaging of the TMJ. This article focuses on state of the art imaging of the temporomandibular joint. Relevant normal anatomy and biomechanics of movement of the TMJ are discussed for better understanding of many TMJ pathologies. Imaging of internal derangements is discussed in detail. Different arthropathies and commontumors are also discussed in this article. | Asim K Bag Santhosh Gaddikeri Aparna Singhal Simms Hardin Benson D Tran Josue A Medina Joel K Curé | 2014 | World Journal of Radiology2014，6，8： | 5 |
| 3 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 4 | Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis显示文摘AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic rats.METHODS Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney. | Gloria Segarra Belén Cortina María Dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 5 | Laparoscopically monitored colonoscopic polypectomy: an established form of endoluminal therapy for colorectal polyps显示文摘 | Franklin ME Jr Leyva Alvizo A Abrego Medina D | 2007 | Surg Endosc2007，21，9： | 1 |
| 6 | Comparison of different sample treatments for the analysis of ochratoxin A in must, wine and beer by liquid chromatography显示文摘 | SAEZ J M MEDINA A JOSE V | 2004 | Journal of Chromatography A2004，1029，： | 1 |
| 7 | Polymorphisms in the endothelial protein C receptor gene and thrombophilia显示文摘 | Medina P Navarro S Estelles A | 2007 | Thromb Haemost2007，98，： | 1 |
| 8 | Prolonged vital cartilage graft preservation using tissue culture methods显示文摘 | OSETE JM MEDINA A | 1994 | Eur J Plast Surg1994，17，： | 1 |
| 9 | Downstream processing of polyunsaturated fatty acids显示文摘 | Medina A R Grima E M Gimenez A | 1998 | Biotechnology Advances1998，16，3： | 1 |
| 10 | Montelukast improves pulmonary function measured by impulse oscillometry in children with asthma ( Mio study) 显示文摘 | Nieto A Pamies R Oliver F Medina A Caballero L Mazon A | 2006 | Respir Med2006，100，7： | 1 |
| 11 | Rapamycin-eluting stent for the treatment of bifurcated coronary lesions:a randomized comparison of a simple versus complex strategy显示文摘 | Pan M DE Lezo JS Medina A | 2004 | Am Heart J2004，148，5： | 1 |
| 12 | Concentration of orange juice by reverse osmosis显示文摘 | Medina B G Garcia A | 1988 | Food Process Engineering1988，10，3： | 1 |
| 13 | Glutamate transpoi-ters : a key piece in the glutamate puzzle of major depressive disorder显示文摘 | Medina A Burke S Thompson RC | 2013 | J Psyehiatr Res2013，47，9： | 1 |
| 14 | How social capital and knowledge affect innovation显示文摘 | P6rez-Lufio A Medina C C Lavado A C | 2011 | Jour- nal of Business Research2011，64，12： | 1 |
| 15 | Thermal biology and locomotor performance in Phymaturus calcogaster:are Patagonian lizards vulnerable to climate change?显示文摘Behavioral and physiological traits of ectotherms are especially sensitive to fluctuations of environmental temperature.In particular,niche-specialist lizards are dependent on their physiological plasticity to adjust to changing environmental conditions.Lizards of the genus Phymaturus are viviparous,mainly herbivorous,and inhabit only rock promontories in the steppe environments of Patagonia and the Andes.Herein,we examine the vulnerability of the southernmost Phymaturus species to global warming:the endemic Phymaturus calcogaster,which lives in a mesic environment in eastern Patagonia.We studied body temperatures in the field(T_(b)),preferred body temperatures in a thermogradient(T_(pref)),the operative(T_(e))and environmental temperatures,and the dependence of running performance on body temperature.P.calcogaster had a mean T_(b)(27.04℃)and a mean Te(31.15℃)both lower than their preferred temperature(T_(pref)=36.61℃)and the optimal temperature for running performance(T_(o)=37.13℃).Lizard activity seems to be restraint during the early afternoon due high environmental temperatures.However,both,the high safety margin and warming tolerance suggest that the expected increase in environmental temperatures due to global warming(IPCC report in 2018)would not threaten,but indeed enhance locomotor performance in this population. | Rosa L.OBREGÓN Jose A.SCOLARO Nora R.IBARGÜENGOYTÍA Marlin MEDINA | 2021 | Integrative Zoology2021，16，1： | 1 |
| 16 | Central nervous system involvement in a child with polyarteritis nodosa and severe atopic demlatitis显示文摘 | Morfin-Maciel B Medina A Espinosa-Rosales F | 2002 | Rev Alerg Mex2002，49，6： | 1 |
| 17 | Evidence of genetic heterogeneity in the long QT syndrome显示文摘 | Kalman YM Medina A | 1993 | Science1993，260，5116： | 1 |
| 18 | On the origin of power laws in Internet topologies显示文摘 | Matta I | 2000 | ACM Computer Communication Review2000，30，2： | 1 |
| 19 | 显示文摘 | Colas B Le Meste M | 1992 | J Food Sci1992，57，3： | 1 |
| 20 | Linear transceiver design in nonregenerative relays with channel state information显示文摘 | Medina O M Vidal J Agustin A | 2007 | IEEE Trans on Signal Processing2007，55，6： | 1 |
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