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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 3 | Simultaneous multi-tear exclusion:an optimal strategy for type B thoracic aortic dissection initially proved by a single center's 8 years experience显示文摘背景 Endovascular 接枝stent 广泛地被用来对待胸的大动脉的 dissection.However ,很少信息都不关于跟随八年用为斯坦福的治疗的同时的多眼泪排除的经验打 B 胸的大动脉的解剖导致到1月2006,29日类型 B 胸的大动脉的解剖病人的从1998年9月的没有不利 events.Methods 的成功的大动脉的改变的多重 tears.This 报告细节的同时的排除的结果是可得到的( 24 个人, 5 | YUAN Liang-xi BAO Jun-min ZHAO Zhi-qing FENG Xiang OU Le-feng FENG Rui LU Qing-sheng MEI Zhi-jun JING Zai-ping Department of Vascular Surgery,Changhai Hospital,Second Military Medical University Institute of Vascular Surgery of Chinese People’s Liberation Army Clinic Center of Vascular Diseases of Shanghai National Key Department of Vascular Surgery of China Shanghai 200433,China (Yuan LX,Bao JM,Zhao ZQ,Feng X,Ou LF,Feng R,Lu QS,Mei ZJ and Jing ZP) | 2007 | Chinese Medical Journal2007，，24： | 3 |
| 4 | Use of multi-objective genetic algorithms to optimize inter-vehicle active suspension显示文摘 | Mei T X Goodall R M | 2002 | Journal of Rail and Rapid Transit2002，，： | 2 |
| 5 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 6 | Study of the friction error for a high-speed high precision table显示文摘 | Mei X S Tsutsumi M S Yamazaki T | 2001 | Machine Tool & Manufacturing2001，41，： | 1 |
| 7 | Computer modelling and tooling design for near net shaped components using hot isostatic pressing 显示文摘 | YUAN W X MEI J SAMAROV V SELIVERSTOV D WU X | 2007 | Journal of Materials Processing Technology2007，182，123： | 1 |
| 8 | Identification of a Spindlin homolog in gibel carp(Carassius auratus gibelio)显示文摘 | Wang X L Sun M Mei J | 2005 | Comp Biochem Physiol2005，141，： | 1 |
| 9 | Improved biological characteristics of poly(L-lactic acid) electrospun membrane by incorporation of multiwalled carbon nanotubes/ hydroxyapatite nanoparticles 显示文摘 | Mei F Zhong J Yang X | 2007 | Biomacromolecules2007，8，12： | 1 |
| 10 | Reversible lithiumion storage in silve~treated nanoscale hollow porous silicon particles 显示文摘 | D Y Chen X Mei G Ji | 2012 | Angewandte Chemic International Edition2012，51，10： | 1 |
| 11 | Robust visual tracking and vehicle classificationvia sparse representation显示文摘 | MEI X LING H | 2011 | IEEE Transactions on Pattern Analy-sis and Machine Intelligence2011，33，11： | 1 |
| 12 | The long-term incidence of subse- quent vertebral body fracture after vertebral augmentation therapy: a systemic review and meta-analysis显示文摘 | Zou J Mei X Zhu X | 2012 | Pain Physician2012，15，4： | 1 |
| 13 | The crustal and upper mantle structures beneath the northeastern margin of Tibet显示文摘 | Shen X Z Mei X P Zhang Y S | 2011 | Bull Seismol Soc Am2011，101，6： | 1 |
| 14 | In vivo transfection of C/EBP-alpha gene could ameliorate CCL(4)-induced hepatic fibrosis in mice显示文摘 | Mei S Wang X Zhang J | 2007 | Hepatol Res2007，37，7： | 1 |
| 15 | The role of stereotactic radiosurgery in cavernous sinus hemangiomas:a systematic review and meta-analysis显示文摘 | Wang X Mei G Liu X | | 0，，： | 1 |
| 16 | Reconstruction of distal limb defects with the free medial sural artery perforator flap显示文摘 | Wang X Mei J Pan J | | 0，，： | 1 |
| 17 | A Multiple Maximum Scatter Difference Discriminant Criterion for Facial Feature Extraction显示文摘 | Song F X Zhang D Mei D Y | | 0，，： | 1 |
| 18 | A real time video fire flame and smoke detection algorithm 显示文摘 | Yu C Mei Z Zhang X | 2013 | Procedia Engineering2013，62，： | 1 |
| 19 | Study on the load distribution of ball screws with errors 显示文摘 | Mei X S Tsutsumi M Tao T | 2003 | Mechanism and Machine Theory2003，38，11： | 1 |
| 20 | LED-induced fluor escence system for tea classification and quality assessment 显示文摘 | DONG YJ LIU X MEI L | 2014 | J Food Eng2014，137，： | 1 |
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