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| 1 | Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells显示文摘Homocysteine (Hcy ) 为心血管的事件作为一个流行风险因素被认出了。装载胆固醇的泡沫房间是动脉粥样硬化患者损害的一个中央部件。ATP 有约束力的盒子 transporter A1 (ABCA1 ) 它调停细胞的胆固醇和 phospholipids 的流出,是在类脂化合物的限制率的步新陈代谢。酰辅酶 A:cholesterol acyltransferase-1 (ACAT1 ) 在巨噬细胞支持胆固醇酉旨的累积,从而导致泡沫房间形成,在动脉粥样硬化的早舞台的一个特点。在这研究,有教养的导出单核白血球的泡沫房间为 24 h 与 Hcy 的临床的相关集中被孵化。胆固醇的房间和累积被发现的泡沫的两个都增加的数字,和 ABCA1 的 mRNA 和蛋白质表示层次被减少,当 ACAT1 表示面对 Hcy 被增加时。而且,而 ACAT1 DNA methylation 被使用 Hcy 的不同集中减少, ABCA1 基因的 DNA methylation 水平被增加。而且,我们的结果显示出那项 DNA methyltransferase (DNMT ) 活动和 DNA methyltransferase 1 (DNMT1 ) mRNA 表示被 Hcy 增加。DNA methylation 有功能经由 DNMT 调整 ABCA1 和 ACAT1 的表示,这被显示。在结论,这些结果建议 Hcy 导致的 ABCA1 和 ACAT1 DNA methylation 可以在导出单核白血球的泡沫房间在 ABCA1 和 ACAT1 表示和胆固醇的累积起一个潜在的作用。 | Yu Liang Xiaoling Yang Linna Ma Xin Cai Lei Wang Cheng Yang Guizhong Li Minghao Zhang Weiwei Sun Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 26 |
| 2 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 3 | SUPERCONVERGENCE ANALYSIS OF THE STABLE CONFORMING RECTANGULAR MIXED FINITE ELEMENTS FOR THE LINEAR ELASTICITY PROBLEM显示文摘在这份报纸,我们基于 Hellinger-Reissner 变化原则考虑线性弹性问题。为压力和排水量和排水量的全球 superconvergence 结果的一个 O (h2 ) 顺序 superclose 性质被采用 Cl 茅 m ent 插值,不可分的身份和适当 postprocessing 技术建立。[从作者抽象] | Dongyang Shi Minghao Li | 2014 | Journal of Computational Mathematics2014，32，2： | 15 |
| 4 | Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis显示文摘Endoplasmic 蜂窝胃(嗯) 应力作为不同病理学的过程的一个重要调节的人并且作为贡献导致的 homocysteine (Hcy ) 的机制正在出现 hepar 损害。然而,分子的事件导致 Hcy 嗯在在动脉粥样硬化背景下面的 hepar 的应力当前是未知的。Endoplasmic 蜂窝胃 oxidoreductin (ERO1 ) 1 在维持起一个关键作用嗯压力功能。在这研究,我们在 hepacytes 在 hyperhomocysteinemia 和 ERO1 的效果在 hepar 决定了 ERO1 的表示嗯应力面对 Hcy。HHcy 模型被在 apolipoprotein-E-deficient (ApoE-/-) 喂蛋氨酸食谱建立老鼠,和 hepatocytes 与 Hcy 的叶酸、不同的集中被孵化。我们的结果证明 Hcy 被触发嗯应力描绘了由一调整葡萄糖的蛋白质的增加的内容 78 (GRP78 ) ,蛋白质 kinase 象 RNA 一样嗯 kinase (津贴) ,激活抄写因素(ATF ) 6 并且 X 盒子有约束力的 protein-1 (XBP-1 ) 。在 HHcy 老鼠和对待 Hcy 的 hepatocytes 的 ERO1 表情在 ApoE-/- 组和控制 hepacytes 与那些相比被减少(P < 0.05 ) 分别地。有小介入的 RNA 的 ERO1 的表示显著地扩充了的敲门下面导致 Hcy 嗯应力。同时,表情嗯压力相关的因素包括 GRP78,津贴, ATF6 和 XBP-1,当 ERO1 基因在 hepacytes 是过去表示的时,显著地被减少。我们的结果建议 ERO1 可以涉及导致 Hcy 的 hepar 嗯 ERO1 表示的应力,和抑制能加速这进程。 | Xiaoling Yang Hua Xu Yinju Hao Li Zhao Xin Cai Jue Tian Minghao Zhang Xuebo Han Shengchao Ma Jun Cao Yideng Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 14 |
| 5 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 6 | Degradation of bisphenol-A using ultrasonic irradiation assisted by low-concentration hydrogen peroxide显示文摘This study investigated the degradation of bisphenol-A (BPA) by ultrasonic irradiation in the presence of different additives (H2O2,air bubbles and humic acid) under various operating conditions,i.e.,ultrasonic frequency,power intensity and power density.The results demonstrated that the BPA degradation followed pseudo first-order kinetics under different experimental conditions.The optimum power intensities were 0.9,1.8,and 3.0W/cm 2 at the frequencies of 400,670,and 800 kHz,respectively.At the fixed frequency (800 kHz),the degradation rate of BPA was shown proportional to the increase of power density applied.With this manner,the BPA sonolysis could be facilitated at H2O2 dosage being lower than 0.1 mmol/L;while BPA degradation was hindered at H2O2 concentration in excess of 1 mmol/L.Additionally,BPA removal was shown to be inhibited by the presence of aeration and humic acid during ultrasonic irradiation.The present study suggested that the degradation rate of BPA assisted by ultrasonic irradiation was influenced by a variety of factors,and high BPA removal rate could be achieved under appropriate conditions. | Kejia Zhang Naiyun Gao Yang Deng Tsair Fuh Lin Yan Ma Lei Li Minghao Sui | 2011 | Journal of Environmental Sciences2011，23，1： | 9 |
| 7 | An Improved Radar Emitter Recognition Method Based on Dezert-Smarandache Theory显示文摘The parameters of radar emitter are fast changing in the current complicated electromagnetic environment, and the radar emitter recognition rate which used single sensor method cannot satisfied. To solve the problem, an improved radar emitter recognition method based on Dezert-Smarandache theory is proposed, which can improve proportional conflict redistribution rule to solve fuzzy and conflicting information from radar emitter. Some examples are given to show the validity of the improved method. | CHEN Changxiao HE Minghao LI Hongfei | 2015 | Chinese Journal of Electronics2015，24，3： | 7 |
| 8 | Large-scale blow spinning of heat-resistant nanofibrous air filters显示文摘Particulate matter(PM)pollution has become a serious problem worldwide and various kinds of nanofibrous filters aiming to solve the problem have been developed.It is urgent to remove PM from high-temperature pollution sources,such as industrial emissions,coal furnaces,and automobile exhaust gases.However,filtration at pollution sources remains challenging because most existing air filters are not resistant to high temperature.Herein,heat-resistant polyimide(PI)nanofibrous air filters are fabricated via a simple and scalable solution blow-spinning method.These air filters show excellent thermal stability at high temperature up to 420℃.They exhibit a filtration efficiency as high as 99.73%at ambient temperature and over 97%at 300℃.In addition,a field test shows that the filters remove>97%of PM from the car exhaust fumes.Hence,the blow-spun PI nanofibrous membranes combined with the facile preparation strategy have great potential in high temperature air filtration fields and other similar applications such as water purification and protein separation. | Ziwei Li Jianan Song Yuanzheng Long Chao Jia Zhenglian Liu Lei Li Cheng Yang Junchen Liu Sen Lin Haiyang Wang Yibo Liu Minghao Fang Hui Wu | 2020 | Nano Research2020，13，3： | 6 |
| 9 | Load-sharing mechanism in timber-steel hybrid shear wall systems显示文摘The lateral performance of timber-steel hybrid shear wall systems with regard to the interaction between the steel frame and the intill wood shear wall was investigated in this paper. A numerical model for the timber-steel hybrid shear wall system was developed and verified against test results. Design parameters, such as the lateral infill-to-frame stiffness ratio and the arrangements of wood-steel bolted connections were studied using the numerical model. Some design recommendations were also proposed based on the parametric analysis. In the hybrid shear wall system, the infill wood wall was found to resist a major part of the lateral load within relatively small wall drifts, and then the steel frame provided more lateral resistance. Under seismic loads, the infill wood wall could significantly reduce the inter-story drift of the hybrid system, and a complementary effect between the infill wood wall and the steel frame was observed through different lateral load resisting mechanisms, which provided robustness to the hybrid shear wall systems. | Zheng LI Minjuan HE Frank LAM Minghao LI | 2015 | Frontiers of Structural and Civil Engineering2015，9，2： | 5 |
| 10 | Old dogs,new trick:classic cancer therapies activate cGAS显示文摘The discovery of cancer immune surveillance and immunotherapy has opened up a new era of cancer treatment.Immunotherapies modulate a patient's immune system to specifically eliminate cancer cells;thus,it is considered a very different approach from classic cancer therapies that usually induce DNA damage to cause cell death in a cell-intrinsic manner.However,recent studies have revealed that classic cancer therapies such as radiotherapy and chemotherapy also elicit antitumor immunity,which plays an essential role in their therapeutic efficacy.The cytosolic DNA sensor cyclic GMP-AMP synthase(cGAS)and the downstream effector Stimulator of Interferon Genes(STING)have been determined to be critical for this interplay.Here,we review the antitumor roles of the cGAS-STING pathway during tumorigenesis,cancer immune surveillance,and cancer therapies.We also highlight classic cancer therapies that elicit antitumor immune responses through cGAS activation. | Seoyun Yum Minghao Li Zhijian J.Chen | 2020 | Cell Research2020，30，8： | 4 |
| 11 | Enhanced production of seed oil with improved fatty acid composition by overexpressing NAD^(+)-dependent glycerol-3-phosphate dehydrogenase in soybean显示文摘There is growing interest in expanding the production of soybean oils(mainly triacylglycerol, or TAG) to meet rising feed demand and address global energy concerns. We report that a plastidlocalized glycerol-3-phosphate dehydrogenase(GPDH), encoded by GmGPDHp1 gene, catalyzes the formation of glycerol-3-phosphate(G3 P), an obligate substrate required for TAG biosynthesis.Overexpression of GmGPDHp1 increases soybean seed oil content with high levels of unsaturated fatty acids(FAs), especially oleic acid(C18:1), without detectably affecting growth or seed protein content or seed weight. Based on the lipidomic analyses, we found that the increase in G3 P content led to an elevated diacylglycerol(DAG) pool, in which the Kennedy pathwayderived DAG was mostly increased, followed by PC-derived DAG, thereby promoting the synthesis of TAG containing relatively high proportion of C18:1. The increased G3 P levels induced several transcriptional alterations of genes involved in the glycerolipid pathways. In particular, genes encoding the enzymes responsible for de novo glycerolipid synthesis were largely upregulated in the transgenic lines, in-line with the identified biochemical phenotype. These results reveal a key role for GmGPDHp1-mediated G3 P metabolism in enhancing TAG synthesis and demonstrate a strategy to modify the FA compositions of soybean oils for improved nutrition and biofuel. | Ying Zhao Pan Cao Yifan Cui Dongxu Liu Jiapeng Li Yabin Zhao Siqi Yang Bo Zhang Runnan Zhou Minghao Sun Xuetian Guo Mingliang Yang Dawei Xin Zhanguo Zhang Xin Li Chen Lv Chunyan Liu Zhaoming Qi Jingyu Xu Xiaoxia Wu Qingshan Chen | 2021 | Journal of Integrative Plant Biology2021，63，6： | 4 |
| 12 | An open conformation determined by a structural switch for 2A protease from coxsackievirus A16显示文摘Coxsackievirus A16 belongs to the family Picornaviridae,and is a major agent of hand-foot-and-mouth disease that infects mostly children,and to date no vaccines or antivi-ral therapies are available.2A protease of enterovirus is a nonstructural protein and possesses both self-cleavage activity and the ability to cleave the eukaryotic translation initiation factor 4G.Here we present the crystal structure of coxsackievirus A162A protease,which interestingly forms hexamers in crystal as well as in solution.This structure shows an open conformation,with its active site accessible,ready for substrate binding and cleav-age activity.In conjunction with a previously reported“closed”state structure of human rhinovirus 2,we were able to develop a detailed hypothesis for the conforma-tional conversion triggered by two“switcher”residues Glu88 and Tyr89 located within the bll2-cII loop.Substrate recognition assays revealed that amino acid residues P1′,P2 and P4 are essential for substrate specificity,which was verifi ed by our substrate binding model.In addition,we compared the in vitro cleavage effi ciency of 2A pro-teases from coxsackievirus A16 and enterovirus 71 upon the same substrates by fl uorescence resonance energy transfer(FRET),and observed higher protease activity of enterovirus 71 compared to that of coxsackievirus A16.In conclusion,our study shows an open conformation of coxsackievirus A162A protease and the underlying mechanisms for conformational conversion and substrate specifi city.These new insights should facilitate the future rational design of effi cient 2A protease inhibitors. | Yao Sun Xiangxi Wang Shuai Yuan Minghao Dang Xuemei Li Xuejun CZhang Zihe Rao | 2013 | Protein & Cell2013，4，10： | 3 |
| 13 | Energy-efficient multipath routing in wireless sensor network considering wireless interference显示文摘Due to the energy and resource constraints of a wireless sensor node in a wireless sensor network (WSN), design of energy-efficient multipath routing protocols is a crucial concern for WSN applications. To provide high-quality monitoring information, many WSN applications require high-rate data transmission. Multipath routing protocols are often used to increase the network transmission rate and throughput. Although large-scale WSN can be supported by high bandwidth backbone network, the WSN remains the bottleneck due to resource constraints of wireless sensors and the effects of wireless interference. In this paper, we propose a multipath energy-efficient routing protocol for WSN that considers wireless interference. In the proposed routing protocol, nodes in the interference zone of the discovered path are marked and not allowed to take part in the subsequent routing process. In this way, the quality of wireless communication is improved because the effects of wireless interference can be reduced as much as possible. The network load is distributed on multiple paths instead of concentrating on only one path, and node energy cost is more balanced for the entire wireless network. The routing protocol is simulated in NS2 software. Simulation result shows that the proposed routing protocol achieves lower energy cost and longer network lifetime than that in the literature. | Li, Shujiang Ma, Xin Wang, Xiangdong Tan, Minghao | 2011 | 控制理论与应用(英文版)2011，9，1： | 3 |
| 14 | Flexible polyimide-based hybrid optoelectric neural interface with 16 channels of micro-LEDs and electrodes显示文摘In this paper,a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO_(x)-modified microelectrodes for synchronous photostimulation and neural signal recording is presented.The 4×4 micro-LEDs(dimensions of 220×270×50μm^(3),700μm pitch)are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method.The recording electrodes share a similar fabrication process on the polyimide with 16 microelectrode sites(200μm in diameter and 700μm in pitch)modified by iridium oxide(IrO_(x)).These two subparts can be aligned with alignment holes and glued back-to-back by epoxy,which ensures that the light from the LEDs passes through the corresponding holes that are evenly distributed around the recording sites.The long-term electrical and optical stabilities of the device are verified using a soaking test for 3 months,and the thermal property is specifically studied with different duty cycles,voltages,and frequencies.Additionally,the electrochemical results prove the reliability of the IrO_(x)-modified microelectrodes after repeated pressing or friction.To evaluate the tradeoff between flexibility and strength,two microelectrode arrays with thicknesses of 5 and 10μm are evaluated through simulation and experiment.The proposed device can be a useful mapping optogenetics tool for neuroscience studies in small(rats and mice)and large animal subjects and ultimately in nonhuman primates. | Bowen Ji Zhejun Guo Minghao Wang Bin Yang Xiaolin Wang Wen Li Jingquan Liu | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 15 | A randomized diversification strategy for solving satisfiability problem with long clauses显示文摘Satisfiability problem(SAT) is a central problem in artificial intelligence due to its computational complexity and usefulness in industrial applications. Stochastic local search(SLS) algorithms are powerful to solve hard instances of satisfiability problems, among which CScore SAT is proposed for solving SAT instances with long clauses by using greedy mode and diversification mode. In this paper, we present a randomized variable selection strategy to improve efficiency of the diversification mode, and thus propose a new SLS algorithm.We perform a number of experiments to evaluate the new algorithm comparing with the recently proposed algorithms, and show that our algorithm is comparative with others for solving random instances near the phase transition threshold. | Jian GAO Ruizhi LI Minghao YIN | 2017 | Science China(Information Sciences)2017，60，9： | 3 |
| 16 | Relationships between daily total fluoride intake and dental fluorosis and dental caries显示文摘Objective:To explore the relationships between the daily total intake of fluoride,dental fluorosis and dental caries. Methods: An epidemiological method was used to investigate the daily total intake of fluoride,dental fluorosis,and dental caries among 236 and 290 children aged 8-13 years in a severe endemic area and in a non-fluorosis control area,respectively. The children were divided into eight subgroups according to each child’s estimated daily total intake of fluoride. The prevalence of dental fluorosis and dental caries in each group was calculated. Results: As expected,elevated levels of fluoride intake were significantly associated with a higher prevalence of dental fluorosis and an increasing amount of more severe defect dental fluorosis. When the daily total F intake was 2.78 mg/child/day,the prevalence of dental fluorosis was nearly 100%,with the prevalence of defect dental fluorosis increasing with increasing fluoride intake. There was also a significant negative(inverse) dose-response relationship between the daily total intake of fluoride and the overall preva-lence of dental caries,the prevalence of which decreased when the daily total intake of fluoride increased up to 3.32 mg/child/day. However,at higher levels of daily total intake of fluoride the prevalence of dental caries increased,giving rise to a U-shaped dose-response relationship curve. Conclusion: It is important to monitor total fluoride exposure and protect children from excessive fluoride intake,especially during the years of tooth development. | Quanyong Xiang Minghao Zhou Ming Wu Xinya Zhou Li Lin Jiuning Huan Youxing Liang | 2009 | Journal of Nanjing Medical University2009，23，1： | 3 |
| 17 | Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice显示文摘Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis. | Mumei Wang Xiaopei Zhu Guoqing Peng Minglong Liu Shuqing Zhang Minghao Chen Shitang Liao Xiaoying Wei Peng Xu Xiyu Tan Fangping Li Zhichuan Li Li Deng Ziliang Luo Liya Zhu Shuai Zhao Dagang Jiang Jing Li Zhenlan Liu Xianrong Xie Shaokui Wang Aimin Wu Chuxiong Zhuang Hai Zhou | 2022 | Molecular Plant2022，15，6： | 2 |
| 18 | Structural modification and antitumor activity of antimicrobial peptide HYL显示文摘HYL derived from the venom of the solitary bee Hylaeus signatus(Hymenoptera:Colletidae)is anα-helical antimicrobial peptide with 16 residues.To explore whether HYL can be applied in anti-tumor therapy,we synthesized HYL and further modified its structure by using a solid-phase synthesis method,and then evaluated their antitumor activities.Firstly,we identified the key residues of HYL by alanine scanning strategy,and then a series of stapled peptides were synthesized by hydrocarbon stapling strategy without destroying the key residues.All the stapled peptides of HYL showed significant improvement not only inα-helicity,but also in antitumor activity and protease resistance when compared to the parent peptide HYL.The results showed that hydrophobicity and amphiphilicity are important factors affecting the antitumor activity of HYL,and the stapling strategy can significantly affect the proteolytic stability and helicity of HYL.What’s more,we find that the stapled peptides HYL-14,HYL-16 and HYL-18 show a promising prospect for novel anti-tumor drug development. | Minghao Wu Qing Chen Yingdi Wang Yulei Li Xia Zhao Qi Chang | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 19 | RiceENCODE:A comprehensive epigenomicdatabase as a rice Encyclopedia of DNA Elements显示文摘Dear Editor,Rice(Oryza sativa)is one of the most important crops in the worldand a common model plant for genomic research.The genomesofXian/IndicaandGeng/Japonicahave been completelysequenced and annotated with accurate genome information.Over the past few years,epigenomic information,including DNAmethylation,histone modification,and chromatin accessibility,has been characterized in theXian/IndicaandGeng/Japonicage-nomes(Zhao et al.,2020).Quite a few rice three-dimensionalgenome studies have been published in the meantime(Zhaoet al.,2019).However,it is still a big challenge for many groupsthat lack dedicated bioinformatic personnel or sufficientcomputational resources to utilize such epigenetic data. | Liang Xie Minghao Liu Lun Zhao Kai Cao Peng Wang Wenhao Xu Wing-Kin Sung Xingwang Li Guoliang Li | 2021 | Molecular Plant2021，14，10： | 2 |
| 20 | Different Impacts of Madden–Julian Oscillation on Winter Rainfall over Southern China显示文摘Winter rainfall over southern China is usually enhanced when Madden–Julian oscillation(MJO) is active over the Indian Ocean, but it can be weakened under certain conditions. Here, the diversity of MJO impacts on winter rainfall and its mechanisms are explored by using scenarios of enhanced and suppressed rainfall anomalies over southern China when MJO is active over the Indian Ocean. The combined effects of low-frequency background moisture and intraseasonal winds are the major contributors to the different rainfall anomalies. Anomalous circulation in mid–high latitudes, especially on intraseasonal timescales, is almost opposite in the two scenarios, which can modulate the response of extratropical atmosphere to MJO heating and then induces the different circulations over southern China. In the enhanced scenario, mid–high latitudes of Eurasia and southern China are dominated by positive and negative sea level pressure anomalies, respectively. The southerly over southern China and the South China Sea induced by MJO heating promotes the anomalous moisture convergence and ascending motion over southern China, resulting in the enhanced rainfall. In the suppressed scenario, however, the circulation in mid–high latitudes does not favor rainfall over southern China and leads to the northerly response to MJO heating over southern China, which enhances moisture divergence and weakens rainfall over southern China. | Xiong CHEN Jian LING Chongyin LI Lifeng LI Minghao YANG | 2021 | Journal of Meteorological Research2021，35，2： | 2 |
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