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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Physical activity in primary and secondary prevention of cardiovascular disease:Overview updated显示文摘Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease. | Alberto J Alves Joao L Viana Suiane L Cavalcante Nórton L Oliveira JoséA Duarte Jorge Mota JoséOliveira Fernando Ribeiro | 2016 | World Journal of Cardiology2016，8，10： | 6 |
| 3 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 4 | Finite element dynamic analysis of practical disc 显示文摘 | Mota Soares C A Petyt M | 1978 | J Sound Vibr1978，61，： | 2 |
| 5 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 6 | Genetic polymorphism,medical therapy and sequential cardiac function in patients with heart failure显示文摘 | CUOCO M A PEREIRA A C MOTA GDE F | 2008 | Arq Bras Cardiol2008，90，： | 1 |
| 7 | Effect of resin cements and aging on cuspal deflection and fracture resistance of teeth restored with composite resin inlays显示文摘 | Salaverry A Borges GA Mota EG | 2013 | J Adhes Dent2013，15，6： | 1 |
| 8 | Optimal design for active damping in sandwich structures using the Direct MultiSearch method 显示文摘 | Araujo A L Madeira J F A Mota Soares C M | 2013 | Composite Structures2013，105，： | 1 |
| 9 | Tracheal lipoma mimicking obstructive lung disease显示文摘 | MOTA V T MAIA J G BARBOSA A T | 2010 | J Bras Pneumol2010，36，1： | 1 |
| 10 | Towards property oriented testing 显示文摘 | MACHADO P D L SILVA D A MOTA A C | 2007 | Electrical Notes in Theoretical Computer Science2007，184，： | 1 |
| 11 | Early elimination of cyclosporine in kidney transplant recipients receiving sirolimus prevents progression of chronic pathologic allograft lesions显示文摘 | Ruiz JC Campistol JM Mota A | 2003 | Transpl Proc2003，35，5： | 1 |
| 12 | Preferential ammonium uptake during growth cycle and identification of ammonium transporter genes in young pear trees 显示文摘 | Mota M Neto C B Monteiro A A | 2011 | Journal of Plant Nutrition2011，34，6： | 1 |
| 13 | Piebaldism and neurofibromatosis type 1 :family report 显示文摘 | Duarte AF Mota A Baudrier T | 2010 | Dermatol Online J2010，16，1： | 1 |
| 14 | Development of a finite element model for the identification of mechanical and piezoelectric properties through gradient optimization and experimental vibration data显示文摘 | Araujo A L Mota Soares C M Herskovits J | 2002 | Composite Structures2002，58，： | 1 |
| 15 | Anti-D alloimmunization by weak D type 1 red blood cells with a very low antigen density显示文摘 | Mota M Fonseca NL Rodrigues A | 2005 | Vox Sang2005，88，： | 1 |
| 16 | Gypsicolous flora, conservation and restoration of quarries in the southeast of the Iberian Peninsula显示文摘 | J.F. Mota A.J. Sola M.L. Jiménez-Sánchez F. Pérez-García M.E. Merlo | 2004 | Biodiversity and Conservation2004，，10： | 1 |
| 17 | Enzymatic probe sonication as a tool for solid-liquid extraction for total se-lenium determination by electrothermal-atomic absorption spectrometry 显示文摘 | Vale G Pereira S Mota A | 2007 | Talanta2007，74，2： | 1 |
| 18 | Endothelial nitric oxide synthase gene variant modulates the relationship between serum cholesterol levels and blood pressure in the general population:new evidence for a direct effect of lipids in arterial blood pressure显示文摘 | Pereira A C Sposito A C Mota G F | 2006 | Atherosclerosis2006，184，1： | 1 |
| 19 | Odontogenie keratocyst in maxillary sinus with invasive behavior 显示文摘 | Vencio EF Mota A de Melo Pinho C | 2006 | J Oral Pathol Med2006，35，4： | 1 |
| 20 | Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years显示文摘 | MOTA A | 2004 | Am J Transplant2004，4，6： | 1 |
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