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| 1 | Terlipressin and hepatorenal syndrome: What is important for nephrologists and hepatologists显示文摘Hepatorenal syndrome (HRS) is a reversible form of functional renal failure that occurs with advanced hepatic cirrhosis and liver failure. Despite mounting research in HRS, its etiology and medical therapy has not been resolved. HRS encompasses 2 distinct types. Type 1 is characterized by the rapid development of renal failure that occurs within 2 wk and involves a doubling of initial serum creatinine. Type 2 has a more insidious onset and is often associated with ascites. Animal studies have shown that both forms, in particular type 1 HRS, are often precipitated by bacterial infections and cir-culatory changes. The prognosis for HRS remains very poor. Type 1 and 2 both have an expected survival time of 2 wk and 6 mo, respectively. Progression of liver cir-rhosis and the resultant portal hypertension leads to the pooling of blood in the splanchnic vascular bed. The ensuing hyperdynamic circulation causes an ineffective circulatory volume which subsequently activates neuro-hormonal systems. Primarily the sympathetic nervoussystem and the renin angiotensin system are activated, which, in the early stages of HRS, maintain adequate circulation. Both advanced cirrhosis and prolonged ac-tivation of neurohormonal mechanisms result in fatal complications. Locally produced nitric oxide may have the potential to induce a deleterious vasodilatory effect on the splanchnic circulation. Currently medical therapy is aimed at reducing splanchnic vasodilation to resolve the ineffective circulation and maintain good renal per-fusion pressure. Terlipressin, a vasopressin analogue, has shown potential benefit in the treatment of HRS. It prolongs both survival time and has the ability to re-verse HRS in the majority of patients. In this review we aim to focus on the pathogenesis of HRS and its treatment with terlipressin vs other drugs. | Ahmed A Magan Atif A Khalil Mohamed H Ahmed | 2010 | World Journal of Gastroenterology2010，16，41： | 11 |
| 2 | Catalytic diesel particulate filter显示文摘 | Y Nguyen Huu Nhon H Mohamed Magan C Petit | 2003 | Applied Catalysis B, Environmental2003，，2： | 1 |
| 3 | Impact of environment and interspecific interactions between spoilage fungi and Aspergillus ochraeeus on growth and ochratoxin production in maize grain显示文摘 | Lee H B Magan N | 2000 | International Journal of Food Microbiology2000，61，： | 1 |
| 4 | Control of the an- thracnose pathogen of banana ( Colletotrichum musae) u- sing antioxidants alone and in combination with thiaben- dazole or imazalil 显示文摘 | KHAN S H AKED J MAGAN N | 2001 | Plant Pathology2001，50，5： | 1 |
| 5 | Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development 显示文摘 | Terry K Magan H Baranski M | 2000 | Mech Dev2000，97，12： | 1 |
| 6 | Control of the anthracnose pathogen of banana (Colletotrichum musae) using antioxidants alone and in combination with thiabendazole or imazalil显示文摘 | Khan S H Aked J Magan N | 2001 | Plant Pathology2001，50，8： | 1 |
| 7 | Complex regulation of the aflatoxin biosynthesis gene cluster of Aspergillus flavus in relation to various combinations of water activity and temperature显示文摘 | Schmidt H M Abdel H A Magan N | 2009 | Int J Food Microbiol2009，135，3： | 1 |
| 8 | Sfrp - 1 and sfrp - 2 are expressed in overlapping and distinct domains during chick development 显示文摘 | Terry K Magan H Baranski M | 2000 | Mech Dev2000，97，12： | 1 |
| 9 | Control of the anthracnose pathog- en of banana (Colletotrichum musae) using antioxidants alone and in combination with thiabendazole or imazalil显示文摘 | Khan S H Aked J Magan N | 2001 | Plant Pat- hology2001，50，5： | 1 |
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