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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction显示文摘 | Ambrosioni E Borghi C Magnani B | 1995 | N Engl J Med1995，332，： | 1 |
| 3 | Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives显示文摘 | Leonetti G Magnani B Pessina AC | 2002 | AM J Hypertens2002，15，11： | 1 |
| 4 | The effects of the angiotensin- converting enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction显示文摘 | Ambrosioni E Borghi C Magnani B | 1995 | N Engl J Med1995，332，2： | 1 |
| 5 | Serum free light-chain responses after high-dose intravenous melphalan and autologous stem cell transplantation for AL ( primary ) amyloidosis显示文摘 | Sanchorawala V Seldin D C Magnani B el al | 2005 | Bone Marrow Transplant2005，3，7： | 1 |
| 6 | Early treatment of acute myocardial unfraction with angiotensin converting enzyme inhibition: safely consideration显示文摘 | Ambrosion E Borghic C Magnani B | 1991 | Am J Cardiol1991，68，： | 1 |
| 7 | Tolerability of lorlg-term treatment with lercanidipine versus amlodpine and lacidipine in elderly hypertensives显示文摘 | Leonetti G Magnani B Pessina AC | 2002 | Am J Hyper- tens2002，15，11： | 1 |
| 8 | The effects of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction显示文摘 | AMBROSIONI E BORGHI C MAGNANI B | 1995 | N Engl J Med1995，332，2： | 1 |
| 9 | The effects of the ACEI zofenopril on mortality and morbidity after anterior myocardial infarction显示文摘 | MBROSIONI E BORGHI C MAGNANI B | 1995 | N Engl J Med1995，332，2： | 1 |
| 10 | Tolerabihty of long-term trealment with lercanidipine versus amlodlpine and lacidipine in elderly hypertensives显示文摘 | Leonetti G Magnani B Pessina AC | 2002 | Am J Hypertens2002，15，11： | 1 |
| 11 | Central role of MyD88-dependent dendritic cell maturation and proin- flammatory cytokine production to control Brucella abortus infection显示文摘 | Macedo G C Magnani D M Carvalho N B | 2008 | J Immunol2008，180，2： | 1 |
| 12 | The development of a microrobot system for eolonoseopy 显示文摘 | CARROZZA M C LENCIONI L MAGNANI B | 1997 | Lecture Notes in Computer Science1997，1205，： | 1 |
| 13 | A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N- fucopentaose Ⅱ显示文摘 | Magnani J L Nilsson B Brockhaus M | 1982 | J Biol Chem1982，257，14： | 1 |
| 14 | The SMILE study:rationale,organization and definition of the outcomes显示文摘 | Ambrosionli E Borghi C Magnani B | 1993 | Ann Ital Med Int1993，8，： | 1 |
| 15 | Video-as- sisted thoracoscopic surgery for diagnosis, staging, and management of lung Cancer with suspected mediastinal lymphadenopathy 显示文摘 | Brega Massone PP Conti B Magnani B | 2002 | Surg Laparosc Endosc Percutan Tech2002，12，2： | 1 |
| 16 | Alpha- dihydroergocryptine in the long-term therapy of Parkinson's disease 显示文摘 | Mailland E Magnani P Ottillinger B | 2004 | Arzneimittel-Forschung2004，54，10： | 1 |
| 17 | Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives显示文摘 | Magnani B Pessina AC | 2002 | Am J Hypertens2002，15，11： | 1 |
| 18 | Captopril in mild heart failure: preliminary observations of a longterm doublelind placebo-controlled multicenter trial显示文摘 | Magnani B | 1986 | Postgrad Mad J1986，，： | 1 |
| 19 | The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction显示文摘 | Borghi C Magnani B | 1995 | N Engl J Med1995，332，： | 1 |
| 20 | Effects of the early administration of zofenopril on onset and progression of congestive heart failure in patients with anterior wall acute myocardial infaction显示文摘 | Ambrosioni E Magnani B | 1996 | Am J Cardiol1996，78，： | 1 |
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