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| 1 | QTLs for Sugar Content of Stalk in Sweet Sorghum(Sorghum bicolor L.Moench)显示文摘High sugar content of sorghum stalk is an important factor in the sorghum silage production. To identify the genomic regions controlling sugar content and to develop molecular markers linked to sugar content in sweet sorghum, we used an F2:3 segregating population consisting of 207 individuals derived from a cross between a high sugar content inbred line, Early Folger, and a normal inbred line, N32B, for genetic linkage mapping and quantitative trait locus (QTL) analysis. We constructed a genetic linkage map spanning 983.5 cM based on a total of 327 markers comprising 31 restriction fragment length polymorphism (RFLP) markers, 254 amplified fragment length polymorphism (AFLP) markers, and 42 simple sequence repeat (SSR) markers. In the 20 linkage groups detected, 98.2% of markers aligned to the 10 linkage groups of sorghum. Variations in sugar content at different growth stages and among internodes suggested that the sugar content of middle internodes is stable and suitable for measuring at early dough stage. The broad sense heritability (hB2) of sugar content was 0.64 and 0.62 estimated from the data of F3 families and each parent in 2003 and 2004. We identified one and two QTLs accounting for 22.2 to 25.0% of phenotypic variance using simple interval mapping method in 2003 and 2004, respectively. These two QTLs showed a negative additive effect, and over-dominance effect. A QTL on LG-D was detected in both two years. Above results will be help us to understand the genetic mechanism of sugar content in sorghum and the QTL detected in this study might be useful in the improvement of sugar content by marker-assisted selection. | BIAN Yun-long Yazaki Seiji Inoue Maiko CAI Hong-wei | 2006 | Agricultural Sciences in China2006，5，10： | 24 |
| 2 | 比较内耳内淋巴显像和耳蜗电图及甘油试验在梅尼埃病诊断中的价值显示文摘目的:研究甘油试验、耳蜗电图、3T MRI在梅尼埃病(MD)患者中的关系。方法:评估20例患者,把稀释的钆造影剂通过鼓室注射入患者双侧的鼓室腔,24h后,通过3T MRI评估膜迷路积水的程度,此外为检测耳蜗积水,进行耳蜗电图和甘油试验。结果:经耳蜗电图检测,11例(55%)患者有阳性结果。经甘油试验检测,12例(60%)患者有阳性结果。同时采用甘油试验和耳蜗电图检测同一组患者时,75%的患者有阳性结果。用钆造影剂的3T MRI检查,19例(95%)患者有阳性结果。结论:与耳蜗电图及甘油试验检测相比,鼓室内注射钆造影剂的3T MRI,对内耳膜迷路积水的诊断更有价值。 | HISAKUNI FUKUOKA YUTAKA TAKUMI KEITA TSUKADA MAIKO MIYAGAWA TOMOHIRO OGUCHI HITOSHI UEDA MASUMI KADOYA SHIN-ICHI USAMI 张甦琳 孔维佳 | 2012 | 临床耳鼻咽喉头颈外科杂志2012，26，19： | 16 |
| 3 | Lipopolysaccharide Enhances the Production of Nicotine-Induced Prostaglandin E2 by an Increase in Cyclooxygenase-2 Expression in Osteoblasts显示文摘以前的研究显示了那脂肪的多糖(LPS ) 在匾的 fromGram 否定的细菌导致前列腺素 E_2 (PGE_2 ) 的版本,它在吸烟的 periodontitis,和那棵烟草支持牙槽的骨头再吞可能是为 periodontitis 的发展和严厉的一个重要风险因素。我们在碱性磷酸酶(ALPase ) 上决定了烟碱 andLPS 的效果活动, PGE_2 生产,和表示 ofcyclooxygenase (COX-1, COX-2 ) , PGE_2 受体 Ep1-4,和在人的 osteoblastic Saos-2 房间的巨噬细胞殖民地刺激因素(M-CSF ) 。房间与 10 ~ 是有教养的(-3) M 烟碱面对 0, 1,或 10 μ g /ml LPS,或与 LPS 独自一个。ALPase 活动独自在与烟碱或 LPS 有教养的房间减少了,并且在与烟碱和 LPS 有教养的那些进一步减少了,而 PGE_2 生产显著地在前者增加了并且在后者进一步增加了。由自己,烟碱没影响 COX-1, COX-2,任何 PGE_2 受体,或 M-CSF 的表示,但是烟碱和 LPS 什么时候是现在, COX-2 的表示, Ep3, Ep4,和 M-CSF,显著地增加。10 ~ 的同时的增加(-4) M 消炎痛在 ALPase 活动, PGE_2 生产,和 M-CSF 表示消除了烟碱和 LPS 的效果。proteinkinase A 的 Phosphorylation 在与烟碱和 LPS 有教养的房间高。这些结果建议 LPS 由造骨细胞的 COX-2 表示的增加提高导致烟碱的 PGE_2 的生产, thatnicotine-LPS-induced PGE_2 首先在 autocrine orparacnne 模式与造骨细胞 Ep4 受体交往,并且 nicotine-LPS-induced PGE_2 然后减少 ALPase 活动和 increasesM-CSF 表示。 | Maiko SHOJI Natsuko TANABE Narihiro MITSUI Naoto SUZUKI Osamu TAKEICHI Tomoko KATONO Akira MOROZUMI Masao MAENO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 9 |
| 4 | Elevated plasma cryofibrinogen in patients with active inflammatory bowel disease is morbigenous显示文摘瞄准:在活跃的煽动性的肠疾病(IBD ) 调查冷沉纤维蛋白(CF ) 的角色。方法:CF 是在 284 个题目的 assayed:61 与活跃并且 63 与不活跃的 ulcerative (UC ) , 45 有 proctocolectomy, 35 与活跃并且 20 与不活跃的 Crohn 的疾病(CD ) , 40 与另外的疾病和 20 健康控制。胰岛素禁止者(TI ) 和 TI 抗体(TI-Ab ) 被 ELISA 在血浆和 CF 建筑群测量。结果:在活跃 UC 的 CF 与所有另外的组(c2<0.001 ) 相比惊人地高。同样, CF 比在不活跃的 CD 或在控制(c2<0.01 ) 在活跃 CD 是显著地更高的。在 UC,高 CF 和 TI-Ab 与对操作的需要被联系。进一步,在血浆的高 CF, CF/fibrinogen 比率,低 TI 和高 TI-Ab 与疾病活动或倔强被联系到药。提高的 CF 没与相似 C 反应的蛋白质和白血房间除了红细胞沉降率数的尖锐反应物被联系,建议那提高的 CF 不是急性炎的后果。结论:在活跃 IBD 的提高的 CF 看起来是致病。CF 经由二主要机制支持 IBD, TI (一种反煽动性的物质) 熄灭并且损害由形成蛋白质总数的微脉管的灌注。CF 可以也用作长期的 IBD 的一个简历标记。另外的研究被保证充分在 IBD 评估 CF 的角色,结果应该贡献 IBD 的致病的更好的理解。 | Koji Sawada Ryouki Takahashi Abbi R Saniabadi Maiko Ohdo Takashi Shimoyama | 2006 | World Journal of Gastroenterology2006，12，10： | 7 |
| 5 | Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients显示文摘AIM: To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS: Marker genes were initially identified using DNA microarray data from a rat liver fibrosis model. The expression level of each fibrosis associated marker gene was analyzed using reverse transcription-polymerase chain reaction (RT-PCR) in clinical biopsy specimens from HCV-positive patients (n = 61). Analysis of changes in expression patterns and interactions of marker genes in functional categories was used to assess the biological mechanism of fibrosis. RESULTS: The profile data showed several biological changes associated with progression of hepatic fibrosis. Clustered genes in functional categories showed sequential changes in expression. Several sets of clustered genes, including those related to the extracellular matrix (ECM), inflammation, lipid metabolism, steroid metabolism, and some transcription factors important for hepatic biology showed expression changes in the immediate early phase (F1/F2) of fibrosis. Genes associated with aromatic amino acid (AA) metabolism, sulfur-containing AA metabolism and insulin/ Wnt signaling showed expression changes in the middle phase (F2/F3), and some genes related to glucose metabolism showed altered expression in the late phase of fibrosis (F3/F4). Therefore, molecular networks showing serial changes in gene expression are present in liver fibrosis progression in hepatitis C patients. CONCLUSION: Analysis of gene expression profiles from a perspective of functional categories or molecular networks provides an understanding of disease and suggests new diagnostic methods. Selected marker genes have potential utility for biological identification of advanced fibrosis. | Yoshiyuki Takahara Mitsuo Takahashi Qing-Wei Zhang Hirotaka Wagatsuma Maiko Mori Akihiro Tamori Susumu Shiomi Shuhei Nishiguchi | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 6 | Serum magnesium concentration in children with functional constipation treated with magnesium oxide显示文摘AIM:To determine whether hypermagnesemia recently reported in adult patients possibly develops in children with functional constipation taking daily magnesium oxide.METHODS:We enrolled 120 patients (57 male and 63 female) aged 1-14 years old (median:4.7 years) with functional constipation from 13 hospitals and two private clinics.All patients fulfilled the Rome Ⅲ criteria for functional constipation and were treated with daily oral magnesium oxide for at least 1 mo.The median treatment dose was 600 (500-800) mg/d.Patients were assessed by an interview and laboratory examination to determine possible hypermagnesemia.Serum magnesium concentration was also measured in sex-and agematched control subjects (n=38).RESULTS:In the constipation group,serum magnesium concentration [2.4 (2.3-2.5) mg/dL,median and interquartile range] was significantly greater than that of the control group [2.2 (2.0-2.2) mg/dL] (P < 0.001).The highest value was 3.2 mg/dL.Renal magnesium clearance was significantly increased in the constipation group.Serum magnesium concentration in the constipation group decreased significantly with age (P < 0.01).There was no significant correlation between the serum level of magnesium and the duration of treatment with magnesium oxide or the daily dose.None of the patients had side effects associated with hypermagnesemia.CONCLUSION:Serum magnesium concentration increased significantly,but not critically,after daily treatment with magnesium oxide in constipated children with normal renal function. | Maiko Tatsuki Reiko Miyazawa Takeshi Tomomasa Takashi Ishige Tomoko Nakazawa Hirokazu Arakawa | 2011 | World Journal of Gastroenterology2011，17，6： | 4 |
| 7 | Anal cushion lifting method is a novel radical management strategy for hemorrhoids that does not involve excision or cause postoperative anal complications显示文摘AIM: To describe the anal cushion lifting(ACL) method with preliminary clinical results. METHODS: Between January to September 2007, 127 patients who received ACL method for hemorrhoid was investigated with informed consent. In this study, three surgeons who specialized in anorectal surgery performed the procedures. Patients with grade two or more severe hemorrhoids according to Goligher's classification were considered to be indicated for surgery. The patients were given the choice to undergo either the ACL method or theligation and excision method. ACL method is an original technique for managing hemorrhoids without excision. After dissecting the anal cushion from the internal sphincter muscle, the anal cushion was lifted to oral side and ligated at the proper position. Clinical characteristics and outcomes of patients were recorded including complications after surgery. RESULTS: A total of 127 patients were enrolled. Their median age was 42(19-84) years, and 74.8% were female. In addition, more than 99% of the patients had grade 3 or worse hemorrhoids. The median followup period was 26(0-88) mo, and the median operative time was 15(4-30) min. After surgery, analgesics were used for a median period of three days(0-21). Pain control was achieved using extra-oral analgesic drugs, although some patients required intravenous injections of analgesic drugs. The median duration of the patients' postoperative hospital stay was 7(2-13) d. A total of 10 complications(7.9%) occurred. Bleeding was observed in one patient and was successfully controlled with manual compression. Urinary retention occurred in 6 patients, but it disappeared spontaneously in all cases. Recurrent hemorrhoids developed in 3 patients after 36, 47, and 61 mo, respectively. No anal stenosis or persistent anal pain occurred. CONCLUSION: We consider that the ACL method might be better than all other current methods for managing hemorrhoids. | Gentaro Ishiyama Toshihiko Nishidate Yuji Ishiyama Akihiko Nishio Ken Tarumi Maiko Kawamura Kenji Okita Toru Mizuguchi Mineko Fujimiya Koichi Hirata | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 3 |
| 8 | Ets-1 and Ets-2 Regulate the Expression of MicroRNA-126 in Endothelial Cells显示文摘 | Tamia A. Harris Munekazu Yamakuchi Maiko Kondo Peter Oettgen Charles J. Lowenstein | 2010 | Arteriosclerosis, Thrombosis, and Vascular Biology2010，，： | 2 |
| 9 | Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6—a role of NAD(P)H oxidase in β-cells显示文摘 | Hirotaka Tsubouchi Toyoshi Inoguchi Mieko Inuo Maiko Kakimoto Toshiyo Sonta Noriyuki Sonoda Shuji Sasaki Kunihisa Kobayashi Hideki Sumimoto Hajime Nawata | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 10 | Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction显示文摘 | Kazuo Takayama Mitsuru Inamura Kenji Kawabata Michiko Sugawara Kiyomi Kikuchi Maiko Higuchi Yasuhito Nagamoto Hitoshi Watanabe Katsuhisa Tashiro Fuminori Sakurai Takao Hayakawa Miho Kusuda Furue Hiroyuki Mizuguchi | 2012 | Journal of Hepatology2012，，3： | 1 |
| 11 | Sodium spirulan as a potent inhibitor of arterial smooth muscle cell proliferation in vitro显示文摘 | Toshiyuki K Maiko O Satomi S | 2004 | Life Sci2004，74，： | 1 |
| 12 | Monitoring the expression pattern of around 7,000 Arabidopsis genes under ABA treatments using a full-length cDNA microarray显示文摘 | Motoaki Seki Junko Ishida Mari Narusaka Miki Fujita Tokihiko Nanjo Taishi Umezawa Asako Kamiya Maiko Nakajima Akiko Enju Tetsuya Sakurai Masakazu Satou Kenji Akiyama Kazuko Yamaguchi-Shinozaki Piero Carninci Jun Kawai Yoshihide Hayashizaki Kazuo Shinozaki | 2002 | Functional & Integrative Genomics2002，，6： | 1 |
| 13 | Persistence of immune memory in responders to hepatitis B vaccine 显示文摘 | Poel J | 1990 | Am J Public Health1990，80，： | 1 |
| 14 | Development of a stable isotope dilution UPLC‐MS/MS method for quantification of dexmedetomidine in a small amount of human plasma显示文摘 | Koichi Inoue Tasuku Sakamoto Yoshihito Fujita Saya Yoshizawa Maiko Tomita Jun Zhe Min Kenichiro Todoroki Kazuya Sobue Toshimasa Toyo’oka | 2013 | Biomed. Chromatogr2013，，7： | 1 |
| 15 | Biased distribution Of single nucleotide polymorphisms ( SNPs ) in porcine Toll - like receptor 1 ( TLR1 ), TLR2, TLR4, TL]R5 and TLR6 genes 显示文摘 | Hiroki Shinkai Maiko Tanaka Takeya Morozumi | 2006 | Immunogenetics2006，58，： | 1 |
| 16 | The Star-type color pattern in Petunia hybrida ‘red star' flowers is induced by sequence-specific degradation of chalcone synthase RNA 显示文摘 | Maiko koseki Kazunori Goto Chikara Masuta | 2005 | Plant and Cell physiology2005，46，11： | 1 |
| 17 | Spectral - domain optical coherence tomography images of inner/outer segment junctions and macular hole surgery outcomes显示文摘 | Maiko I Yoichiro W Akira A Shimpei S Satoshi K Kazuaki K | 2009 | Graefes Arch Clin Exp Ophthalmol2009，247，10： | 1 |
| 18 | Strontium-89 (Metastron) and the bisphosphonate olpadronate reduce the incidence of spinal cord compression in patients with hormone-refractory prostate cancer metastatic to the skeleton显示文摘 | Soerdjbalie Maikoe V Pelger RC Lycklama à Nijeholt GA | 2002 | Eur J Nucl Med Mol Imaging2002，29，4： | 1 |
| 19 | Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy in the rat model显示文摘 | Maiko Kaga Heng Li Hidenobu Ohta Kazuaki Taguchi Shigeru Ogaki Hitomi Izumi Masumi Inagaki Shigeru Tsuchiya Kunihiro Okamura Masaki Otagiri Hiromi Sakai Nobuo Yaegashi | 2012 | Life Sciences (-)2012，，11： | 1 |
| 20 | Surface detects the downstream events of active PKCI in antigen- stimulated mast cell 显示文摘 | Maiko T plasmon Takaaki H resonance Tomoko T biosensor | 2008 | Biosensors and Bioeleetronics2008，23，11： | 1 |
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