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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Long-term effects of gravel―sand mulch on soil organic carbon and nitrogen in the Loess Plateau of northwestern China显示文摘Gravel–sand mulch has been used for centuries to conserve water in the Loess Plateau of northwestern China. In this study, we assessed the influence of long-term(1996–2012) gravel–sand mulching of cultivated soils on total organic carbon(TOC), light fraction organic carbon(LFOC), microbial biomass carbon(MBC), total organic nitrogen(TON), particulate organic carbon(POC), mineral-associated organic carbon(MOC), permanganate-oxidizable carbon(KMn O4-C), and non-KMn O4-C at 0–60 cm depths. Mulching durations were 7, 11 and 16 years, with a non-mulched control. Compared to the control, there was no significant and consistently positive effect of the mulch on TOC, POC, MOC, KMn O4-C and non-KMn O4-C before 11 years of mulching, and these organic C fractions generally decreased significantly by 16 years. LFOC, TON and MBC to at a 0–20 cm depth increased with increasing mulching duration until 11 years, and then these fractions decreased significantly between 11 and 16 years, reaching values comparable to or lower than those in the control. KMn O4-C was most strongly correlated with the labile soil C fractions. Our findings suggest that although gravel–sand mulch may conserve soil moisture, it may also lead to long-term decreases in labile soil organic C fractions and total organic N in the study area. The addition of manure or composted manure would be a good choice to reverse the soil deterioration that occurs after 11 years by increasing the inputs of organic matter. | Yang QIU ZhongKui XIE YaJun WANG Sukhdev S MALHI JiLong REN | 2015 | Journal of Arid Land2015，7，1： | 7 |
| 3 | 载体对铁基催化剂结构及CO2加氢制烯烃反应性能的影响特性显示文摘铁基催化剂CO2加氢直接合成烯烃是实现CO2减排及CO2转化与利用的最佳途径之一。目前铁基催化剂的CO2加氢活性及反应过程中铁基催化剂结构强度仍然较低,成为CO2加氢制烯烃产业化生产的重要挑战。通过浸渍法制备一系列负载型铁基催化剂,研究载体材料性质对铁基催化剂结构及CO2加氢直接合成烯烃的影响特性。研究发现,载体可诱导铁基催化剂在CO2加氢反应过程中形成的铁物种,同时影响铁基催化剂表面碳物种的有序度,调变对CO2吸附及活化能力;研究结果表明ZrO2负载的Fe催化剂展现出最佳的CO2加氢合成烯烃催化性能,在温度320℃和反应压力2.0 MPa时,CO2转化率>30%,C2~C7烃类产物中烯烃选择性高达85%以上,烯烷比为8.2,且CO选择性较低为17.1%。 | 刘洋洋 孙超 Malhi Haripal Singh 位重洋 张振洲 涂维峰 | 2020 | 化工学报2020，71，10： | 4 |
| 4 | Cellular and Molecular Mechanisms of Liver Injury显示文摘 | Harmeet Malhi Gregory J. Gores | 2008 | Gastroenterology2008，，6： | 4 |
| 5 | Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease显示文摘 | Harmeet Malhi Gregory Gores | 2008 | Semin Liver Dis2008，，04： | 2 |
| 6 | Narratives in Mamluk architecture: Spatial and perceptual analyses of the madrassas and their mausoleums显示文摘 | Shatha Malhis | 2016 | Frontiers of Architectural Research2016，5，1： | 2 |
| 7 | Cholangiocarcinoma: Modern advances in understanding a deadly old disease显示文摘 | Harmeet Malhi Gregory J. Gores | 2006 | Journal of Hepatology2006，，6： | 2 |
| 8 | Properties of cryopreserved fetal liver stem/progenitor cells that exhibit long-term repopulation of the normal rat liver显示文摘 | Malhi H Irani AN Gagandeep S | 2002 | Cell Sci2002，115，13： | 1 |
| 9 | A re-evaluation of long-term flux measurement techniques, Part I:Averaging and coordinate rotation显示文摘 | Finnigan J J Clement R Malhi Y | 2003 | Bound-Layer Meteor2003，107，： | 1 |
| 10 | Effects of rainfall harvesting and mulching technologies on water use efficiency and crop yield in the semi-arid Loess Plateau, China显示文摘 | Wang Y J Xie Z K Malhi S S | 2009 | Agricultural Water Management2009，96，3： | 1 |
| 11 | Optimal frequency of lithium admin- istration in the treatment of bipolar disorder, clinical and dosing considerations显示文摘 | Malhi GS Tanious M | 2011 | CNS Drugs2011，25，4： | 1 |
| 12 | Depression:arole for neurosurgery显示文摘 | Malhi GS Bartlett JR | | 0，，： | 1 |
| 13 | Physicochemical and thermal properties of starches separated from corn produeed from crosses of two germ pools显示文摘 | Sandhu K Singh N Malhi N | 2005 | Food Chemistry2005，89，： | 1 |
| 14 | Cholangiocarcinoma: modern advances in understanding a deadly old disease 显示文摘 | Malhi H Gores GJ | 2006 | J Hepatol2006，45，6： | 1 |
| 15 | Ligh fraction organic N,ammonium,nitrate and total N in a thin black chernozemic soil under bromegrass after 27 annual applications of different N rates显示文摘 | Malhi S S Harapiak J T Nyborg M | 2003 | Nutritient Cycling in Agroecosystem2003，65，： | 1 |
| 16 | The carbon bal- ance of tropical, temperate and boreal forests显示文摘 | Malhi Y Baldocchi D D Jarvis P G | 1999 | Plant Cell & Environment1999，22，6： | 1 |
| 17 | Endoplasmic reticulum stress in liver disease显示文摘 | Malhi H Kaufman RJ | 2011 | J Hepatol2011，54，4： | 1 |
| 18 | Physicochemical and Thermal Properties of Starches Separated from Corn Produced from Crosses of Two Germ Pools显示文摘 | Sandhu K S Singh N Malhi N S | 2005 | Food Chemistry2005，89，： | 1 |
| 19 | The role of theophylline in prevention of radiocontrast media-induced nephropathy显示文摘 | Malhis M Al-Bitar S Al-Deen Zaiat K | 2010 | Saudi J Kidney Dis Transpl2010，21，2： | 1 |
| 20 | Hepatocyte transplantation: new horizons and challenges显示文摘 | Malhi H Gupta S | 2001 | J Hepatobiliary Pancreat Surg2001，8，1： | 1 |
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