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| 1 | Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction显示文摘Historically,influenza pandemics have arisen from avian influenza viruses.Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates.Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%,which has been attributed to dysregulation of the cytokine system.Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus.The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated.In the present study,we demonstrate that autophagy,a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents,plays a role in cytokine induction.Autophagy is induced to a greater extent by H9N2/G1,in association with cytokine hyperinduction,compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses.Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene,Atg5,we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-a expression in primary human blood macrophages.Our results provide new insights into the pathogenic mechanisms of avian influenza viruses. | Anna Hing-Yee Law Davy Chun-Wai Lee Kwok-Yung Yuen Malik Peiris Allan Sik-Yin Lau | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 2 | Avian influenza virus directly infects human natural killer cells and inhibits cell activity显示文摘Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity. | Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung Lau Wenwei Tu | 2017 | Virologica Sinica2017，32，2： | 4 |
| 3 | 感染人类的禽流感病毒A(H5N1)研究进展显示文摘 | Abdel-Nasser Abdel-Ghafar Tawee Chotpitayasunondh Zhancheng Gao Frederick G. Hayden Nguyen Duc Hien Menno D. de Jong Azim Naghdaliyev J.S. Malik Peiris Nahoko Shindo Santoso Soeroso Timothy M. Uyeki 钟晓琴(译) 王关嵩(校) | 2009 | 中华肺部疾病杂志(电子版)2009，2，1： | 4 |
| 4 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 5 | Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis显示文摘 | Lok Yung Chan Hoi Hin Kwok Renee Wan Yi Chan Malik Joseph Sriyal Peiris Nai Ki Mak Ricky Ngok Shun Wong Michael Chi Wai Chan Patrick Ying Kit Yue | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 6 | Avian influenza viruses in humans 显示文摘 | Malik Peiris JS | 2009 | Rev Sci Tech2009，28，1： | 1 |
| 7 | Avian influenza viruses in humans 显示文摘 | Malik Peiris JS | 2009 | Rev Sci Tech2009，28，1： | 1 |
| 8 | H5N1禽流感病毒继续流行和变异——H5N1病毒正以不可预测的方式继续发生变异,对鸟类和人类构成严重威胁显示文摘高致病H5N1流感病毒的变体从亚洲传播到印度、欧洲和非洲,并持续在中国的东南部进化,产生了新的突变体,研究者担心由此引发病毒传播到各地及在全球野生鸟类中流行。到目前为止,在感染H5N1病毒的250例中,半数以上死亡。为控制病毒传播,亚洲有2亿多的家禽被宰杀。HSN1病毒打破了有关流感病毒的一些观念,包括何种鸟可以平安地传播病毒,何种鸟中病毒能致病和致死,以及何种猫可被感染并且能够传播病毒等。一旦在一个地区内一株特别的流感病毒在鸟类中广泛传播时,对家禽扑杀的控制措施应当扩大,同时配合使用疫苗。 | Robert G. Webster Yi Guan Malik Peiris 修文琼(译) 张拥军(校) | 2008 | 海峡预防医学杂志2008，14，3： | 1 |
| 9 | Avian Influenza Vi-rus(H5N1):a Threat to Human Health显示文摘 | Malik J S Peiris M D d J Guan Y | 2007 | Clin Mi-crobiol2007，20，2： | 1 |
| 10 | Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans显示文摘 | J.S. Malik Peiris Leo L.M. Poon Yi Guan | 2009 | Journal of Clinical Virology2009，，3： | 1 |
| 11 | A novel luciferase immunosorbent assay performs better than a commercial enzyme-linked immunosorbent assay to detect MERS-CoV specific IgG in humans and animals显示文摘The Middle East respiratory syndrome(MERS)is a lethal zoonosis caused by MERS coronavirus(MERS-CoV)and poses a significant threat to public health worldwide.Therefore,a rapid,sensitive,and specific serologic test for detecting anti-MERS-CoV antibodies in both humans and animals is urgently needed for the successful management of this illness.Here,we evaluated various novel luciferase immunosorbent assays(LISA)based on nucleocapsid protein(NP)as well as fragments derived from spike protein(S)including subunit 1(S1),N terminal domain(NTD),receptorbinding domain(RBD)and subunit 2(S2)of S for the detection of MERS-CoV-specific IgG.Fusion proteins,including nanoluciferase(NLuc)and various fragments derived from the NP or S protein of MERS-CoV,were expressed in human embryonic kidney 293 T cells.LISAs that detected anti-MERS-CoV IgG were further developed using cell lysates expressing various fusion proteins.Panels of human or animal samples infected with MERS-CoV were used to analyze the sensitivity and specificity of various LISAs in reference to a MERS-CoV RT-PCR,commercial S1-based ELISA,and pseudovirus particle neutralization test(ppNT).Our results showed that the S1-,RBD-,and NP-LISAs were more sensitive than the NTD-and S2-LISAs for the detection of anti-MERS-CoV IgG.Furthermore,the S1-,RBD-,and NP-LISAs were more sensitive(by at least 16-fold)than the commercially available S1-ELISA.Moreover,the S1-,RBD-,and NPLISA specifically recognized anti-MERS-CoV IgG and did not cross-react with samples derived from other human CoV(OC43,229E,HKU1,NL63)-infected patients.More importantly,these LISAs proved their applicability and reliability for detecting anti-MERS-CoV IgG in samples from camels,monkeys,and mice,among which the RBD-LISA exhibited excellent performance.The results of this study suggest that the novel MERS-CoV RBD-and S1-LISAs are highly effective platforms for the rapid and sensitive detection of anti-MERS-CoV IgG in human and animal samples.These assays have the potential to be used as serologic tests for the management and control of MERS-CoV infection. | Wenling Wang Tianyu Wang Yao Deng Peihua Niu Ruhan A Jincun Zhao Malik Peiris Shixing Tang Wenjie Tan | 2019 | Biosafety and Health2019，1，3： | 1 |
| 12 | H5N1Outbreaks and Enzootic Influenza显示文摘 | ROBERT G WEBSTER MALIK PEIRIS | 2006 | Emerging Infectious Diseasea2006，12，： | 1 |
| 13 | Emergence of a novel swine-origin influenza A virus(S-OIV)H1N1virus in humans显示文摘 | Malik Peiris J S POON L L M GUAN Y | 2009 | Journal of Clinical Virology2009，45，3： | 1 |
| 14 | Emergence of a novel swine-origin influenza a virus (S- OIV) HIN1 virus i n humans显示文摘 | Peiris J S Malik Poon Leo L M Guan Yi | 2009 | Journal of ClinicalVirology2009，45，3： | 1 |
| 15 | Avian influenza virues in humans 显示文摘 | Malik Peiris JS | 2009 | Rev Sci Tech2009，28，1： | 1 |
| 16 | A novel H1N1 virus causes the first pandemic of the 21 st century显示文摘 | JS Malik Peiris Wen -wei Tu Hui - ling Yen | 2009 | European J I mmunol2009，39，： | 1 |
| 17 | Emergence of a novel swine-origin influenza A virus (S-OIV) (H1N1) in humans显示文摘 | Malik Peiris J S Leo L M Poon Yi Guan | 2009 | Journal of Clinical Virology2009，45，： | 1 |
| 18 | Adenovirus respiratory infection in hospitalized children in Hong Kong: serotype–clinical syndrome association and risk factors for lower respiratory tract infection显示文摘 | Shuk-Kuen Chau So-lun Lee Malik J. S. Peiris Kwok-Hung Chan Eunice Chan Wilfred Wong Susan S. Chiu | 2014 | European Journal of Pediatrics2014，，3： | 1 |
| 19 | Avian influenza viruses in humans 显示文摘 | Malik Peiris JS | 2009 | Rev Sci Tech2009，28，1： | 1 |
| 20 | Avian influenza virues in humans 显示文摘 | Malik Peiris JS | 2009 | Rev Sci Tech2009，28，1： | 1 |
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