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| 1 | Current advances in humanized mouse models显示文摘收到了人的房间或纸巾的人性化的老鼠模型移植在基本、适用的人的疾病研究是极其有用的。高度 immunodeficient 老鼠,不拒绝异种皮移植和支持细胞和织物区别和生长,为产生另外的适当模型是不可缺少的。自从 2000 年代初,为产生人性化的老鼠适当的一系列 immunodeficient 老鼠是连续地由介绍 IL-2Rγ 发展了; 空 基因(例如, NOD/SCID/γ c 空 和 Rag2 空 γc 空 老鼠) 。这些紧张显示出不仅高度人的房间嫁接评价,而且产生区分得好的 multilineage 在人的造血的干细胞(HSC ) 以后的人的造血的房间移植。这些人性化的老鼠在 vivo 便于人的血液学和免疫学的分析。然而,从 HSC 开发的人的造血的房间不与那些 phenotypically 并且机能上地总是相同在人。更最近, immunodeficient 老鼠的一个新系列补偿劣势这些。这些老鼠被遗传上介绍人的 cytokine 基因进 NOD/SCID/γ 产生; c 空 和 Rag2 空 γc 空 老鼠。在这评论,我们描述在这些老鼠开发的人的造血的房间的当前的知识。用这些人性化的老鼠的各种各样的人的疾病老鼠模型被总结。 | Ryoji Ito Takeshi Takahashi Ikumi Katano Mamoru Ito | 2012 | Cellular & Molecular Immunology2012，9，3： | 15 |
| 2 | Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses显示文摘Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses.However,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed analysis.Administration of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of GVHD.Immunization with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO mice.Immunization with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO mice.Adoptive cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T cells.ACTs using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be evaluated.Therefore,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice. | Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami | 2018 | Cellular & Molecular Immunology2018，15，11： | 6 |
| 3 | SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression显示文摘 | Kazuyuki Matsushita Toshiko Kajiwara Mai Tamura Mamoru Satoh Nobuko Tanaka Takeshi Tomonaga Hisahiro Matsubara Hideaki Shimada Rei Yoshimoto Akihiro Ito Shuji Kubo Tohru Natsume David Levens Minoru Yoshida Fumio Nomura | 2012 | Molecular Cancer Research2012，，6： | 2 |
| 4 | Profile and removal of endocrine disrupting chemicals by using an ER/AR competitive ligand binding assay and chemical analyses显示文摘An estrogen receptor (ER)/androgen receptor (AR) ligand competitive binding assay (ER/AR-binding assay) and chemical analyses were used to evaluate the endocrine disrupting chemicals (EDCs) behavior of two municipal wastewater treatment plants (WWTPs) (K and S). In the inuents, estrone (E1), androsterone (A), androstenedione (AD), BPA (bisphenol A), NP (nonylphenol) and daidzein (DZ) were detected in high amounts with subsequent 24 h-average concentrations of 350, 1000, 29, 1300, 3900, and 5700 ng/L in K-WWTP and of 310, 620, 59, 1600, 2600, and 8400 ng/L in S-WWTP. The estrogenic (androgenic) activity as 17β-estradiol (E2) equivalents (EEQ) or testosterone (Te) equivalents (TEQ) was consequently 620 ng E2/L (570 ng Te/L) and 580 ng E2/L (800 ng Te/L) for the two WWTPs. The removal eciencies of the above mentioned sole target chemicals were 51%-100% for K-WWTP and 55.6%-100% for S-WWTP. The removal eciencies of EEQ were about 73% for both WWTPs, while the removal eciencies of TEQ were 62.1% for K-WWTP and 98.4% for S-WWTP. In addition, chemical-derived EEQ were about 1.2%-52.4% of those by ER-binding assay for K-WWTP and the corresponding ratios were 1.3%-83.3% for S-WWTP, while chemical derived TEQ were less than 3% of values measured by the AR-binding assay for both WWTPs. | Ze-hua Liu Mamoru Ito Yoshinori Kanjo Atsushi Yamamoto | 2009 | Journal of Environmental Sciences2009，21，7： | 2 |
| 5 | Identification of a key molecular regulator of liver metastasis in humanpancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/γcnull(NOG) mice显示文摘 | Hiroshi Suemizu Makoto Monnai Yasuyuki Ohnishi Mamoru Ito Norikazu Tamaoki Masato Nakamura | 2007 | International Journal of Oncology2007，，： | 1 |
| 6 | Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice显示文摘 | MAMORU K HIROSHI I TETSURO ITO | | 0，，： | 1 |
| 7 | Preparation of injectable auto-forming alginate gel containing simvastatin with amorphous calcium phosphate as a controlled release medium and their therapeutic effect in osteoporosis model rat显示文摘 | Tomoko Ito Mami Saito Tomohiro Uchino Mamoru Senna Michele Iafisco Maria Prat Lia Rimondini Makoto Otsuka | 2012 | Journal of Materials Science: Materials in Medicine2012，，： | 1 |
| 8 | Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer显示文摘 | Levent B. Beder Mehmet Gunduz Mamoru Ouchida Esra Gunduz Akiko Sakai Kunihiro Fukushima Hitoshi Nagatsuka Sachio Ito Noriyasu Honjo Kazunori Nishizaki Kenji Shimizu | 2006 | Journal of Cancer Research and Clinical Oncology2006，，1： | 1 |
| 9 | Estimation of automotive tire force characteristics using wheel velocity显示文摘 | Eiichi Ono Katsuhiro Asano Masaru Sugai Shoji Ito Masaki Yamamoto Mamoru Sawada Yoshiyuki Yasui | 2003 | Control Engineering Practice2003，，12： | 1 |
| 10 | C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn’s disease显示文摘 | Toshifumi Hibi Atsushi Sakuraba Mamoru Watanabe Satoshi Motoya Hiroaki Ito Noriko Sato Toru Yoshinari Kenta Motegi Yoshitaka Kinouchi Masakazu Takazoe Yasuo Suzuki Takayuki Matsumoto Kazuhiko Kawakami Takayuki Matsumoto Ichiro Hirata Shinji Tanaka Toshifu | 2014 | Journal of Gastroenterology2014，，2： | 1 |
| 11 | Diverse expression profiles of 21 rice peroxidase genes显示文摘 | Susumu Hiraga Kimiko Yamamoto Hiroyuki Ito Katsutomo Sasaki Hirokazu Matsui Mamoru Honma Yoshiaki Nagamura Takuji Sasaki Yuko Ohashi | 2000 | FEBS Letters2000，，2： | 1 |
| 12 | Changes in the characteristics of definite Meniere’s disease over time in Japan: a long-term survey by the Peripheral Vestibular Disorder Research Committee of Japan, formerly the Meniere’s Disease Research Committee of Japan显示文摘 | Hideo Shojaku Yukio Watanabe Toshiaki Yagi Masahiro Takahashi Taizo Takeda Tetsuo Ikezono Juichi Ito Takeshi Kubo Mamoru Suzuki Masaya Takumida Noriaki Takeda Nobuhiko Furuya Hiroshi Yamashita | 2009 | Acta Oto-Laryngologica2009，，2： | 1 |
| 13 | Positron emission mammography using Pr:LuAG scintillator – Fusion of optical material study and systems engineering显示文摘 | Akira Yoshikawa Takayuki Yanagida Kei Kamada Yuui Yokota Jan Pejchal Akihiro Yamaji Yoshiyuki Usuki Seiichi Yamamoto Masayasu Miyake Kazuaki Kumagai Katsuhisa Sasaki T.R. dos Santos Mamoru Baba Masatoshi Ito Motohiro Takeda Noriaki Ohuchi Martin Nikl | 2010 | Optical Materials2010，，： | 1 |
| 14 | Multiple Chaos Generator by Neural-Network-Differential-Equation for Intelligent Fish-Catching显示文摘 | Mamoru Minami Akira Yanou Yuya Ito Takashi Tomono | 2013 | 通讯和计算机(中英文版)2013，10，6： | 0 |
| 15 | Clinical efficacy of a combination of Percoll continuous density gradient and swim-up techniques for semen processing in HIV-1 serodiscordant couples显示文摘为了评估从 HIV-1 的精液为人的免疫不全病毒类型 1 的移动( HIV-1 )包括 Percoll 连续密度坡度和修改游泳起来技术的联合的一个过程的临床的功效,感染了男性, 129 的一个总数结合 HIV-1 积极男搭挡和 HIV-1 在在2002年1月和2012年4月之间的 Keio 大学医院被对待的否定女搭挡( serodiscordant 夫妇)被检查。从 129 HIV-1 的 183 精液的一个总数感染了男性被处理。在游泳起来以后,我们成功地在恢复收集了能动精子在 normozoospermia (126/126 精液) 的情况下象 100.0% 一样高的率, oligozoospermia (6/6 ) ,和 asthenozoospermia (36/36 ) 。oligoasthenozoospermia 的恢复率是 86.7%(13/15 ) 。在处理精液,仅仅四精液(4/181:2.2%) 在感染的男性的血显示出与那些一致的病毒的核苷酸序列。在使用这些精子以后,女病人的水平感染和新生儿的没有垂直感染都没被观察。而且,没有明显的不利效果在后代被观察。这个协议允许我们收集在高度的否定能动精子评估的 HIV-1,甚至在男因素盒子中。我们断定我们的协议为减少的 HIV-1 感染并且为产出一个健康孩子是临床上有效的。 | Osamu Inoue Naoaki Kuji Hiroe Ito Mitsutoshi Yamada Toshio Hamatani Aimi Oyadomari Shingo Kato Hideji Hanabusa Keiichi Isaka Mamoru Tanaka | 2017 | Asian Journal of Andrology2017，19，2： | 0 |
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