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| 1 | Prospective study of differential diagnosis of hepatic tumors by pattern-based classification of contrast-enhanced sonography显示文摘AIM: To prospectively evaluate the usefulness of a pattern-based classification of contrast-enhanced sonographic findings for differential diagnosis of hepatic tumors. METHODS: We evaluated the enhancement pattern of the contrast-enhanced sonography images in 586 patients with 586 hepatic lesions, consisting of 383 hepatocellular carcinomas, 89 metastases, and 114 hemangiomas. After injecting a galactose-palmitic acid contrast agent, lesions were scanned by contrast- enhanced harmonic gray-scale sonography in three phases: arterial, portal, and late. The enhancement patterns of the initial 303 lesions were classified retrospectively, and multiple logistic regression analysis was used to identify enhancement patterns that allowed differentiation between hepatic tumors. We then used the pattern-based classification of enhancement we had retrospectively devised to prospectively diagnose 283 liver tumors. RESULTS: Seven enhancement patterns were found to be significant predictors of different hepatic tumors. The presence of homogeneous or heterogeneous enhancement both in the arterial and portal phase was the typical enhancement pattern for hepatocellular carcinoma, while the presence of peritumoral vessels in the arterial phase and ring enhancement or a perfusion defect in the portal phase was the typical enhancement pattern for metastases, and the presence of peripheral nodular enhancement both in the arterial and portal phase was the typical enhancement pattern forhemangioma. The sensitivity, specificity, and accuracy of prospective diagnosis based on the combinations of enhancement patterns, respectively, were 93.2%, 96.2%, and 94.0% for hepatocellular carcinoma, 87.9%, 99.6%, and 98.2% for metastasis, and 95.6%, 94.1%, and 94.3% for hemangioma. CONCLUSION: The pattern-based classification of the contrast-enhanced sonographic findings is useful for differentiating among hepatic tumors. | Kazushi Numata Tetsuo Isozaki Manabu Morimoto Kazuya Sugimori Reiko Kunisaki Toshio Morizane Katsuaki Tanaka | 2006 | World Journal of Gastroenterology2006，12，39： | 18 |
| 2 | Contrast enhanced ultrasound of hepatocellular carcinoma显示文摘Sonazoid(Daiichi Sankyo,Tokyo,Japan),a secondgeneration of a lipid-stabilized suspension of a perfluorobutane gas microbubble contrast agent,has been used clinically in patients with liver tumors and for harmonic gray-scale ultrasonography(US)in Japan since January 2007.Sonazoid-enhanced US has two phases of contrast enhancement:vascular and late.In the late phase of Sonazoid-enhanced US,we scanned the whole liver using this modality at a low mechanical index(MI)without destroying the microbubbles, and this method allows detection of small viable hepatocellular carcinoma(HCC)lesions which cannot be detected by conventional US as perfusion defects in the late phase.Re-injection of Sonazoid into an HCC lesion which previously showed a perfusion defect in the late phase is useful for confirming blood flow intothe defects.High MI intermittent imaging at 2 frames per second in the late phase is also helpful in differentiation between necrosis and viable hypervascular HCC lesions.Sonazoid-enhanced US by the coded harmonic angio mode at a high MI not only allows clear observation of tumor vessels and tumor enhancement, but also permits automatic scanning with Sonazoidenhanced three dimensional(3D)US.Fusion images combining US with contrast-enhanced CT or contrastenhanced MRI have made it easy to detect typical or atypical HCC lesions.By these methods,Sonazoidenhanced US can characterize liver tumors,grade HCC lesions histologically,recognize HCC dedifferentiation, evaluate the efficacy of ablation therapy or transcatheter arterial embolization,and guide ablation therapy for unresectable HCC.This article reviews the current developments and applications of Sonazoid-enhanced US and Sonazoid-enhanced 3D US for diagnosing and treating hepatic lesions,especially HCC. | Kazushi Numata Manabu Morimoto Masaaki Kondo Yosuke Kunishi Tomohiko Sasaki Akito Nozaki Katsuaki Tanaka | 2010 | World Journal of Radiology2010，2，2： | 15 |
| 3 | Differentiation of focal liver lesions using three-dimensional ultrasonography: Retrospective and prospective studies显示文摘AIM: To differentiate focal liver lesions based on enhancement patterns using three-dimensional ultrasonography (3D US) with perflubutane-based contrast agent.METHODS: Two hundred and eighty two patients with focal liver lesions,including 168 hepatocellular carcinomas (HCCs),63 metastases,40 hemangiomas and 11 focal nodular hyperplasias (FNHs),were examined by 3D US with perflubutane-based contrast agent.Tomographic ultrasound images and sonographic angiograms were reconstructed.Among 282 lesions,enhancement patterns of 163 lesions between January 2007 and October 2007 were analyzed retrospectively.Then from November 2007 to May 2008,compared with contrast-enhanced (CE) 2D US,CE 3D US was performed on 119 lesions for prospective differential diagnosis.Sensitivity,specificity,area under receiver operating characteristic curve (Az) and inter-reader agreement were assessed.RESULTS: With the tridimensional view,dominant enhancement patterns were revealed as diffuse enhancement or peripheral ring-like enhancement,followed with washout change for HCCs or metastases,respectively,and peripheral nodular enhancement or diffuse enhancement with spoke-wheel arteries,followed by persistent enhancement for hemangiomas or FNHs,respectively.At CE 3D US,the prospective differentiation of lesions showed sensitivity 92% (mean for two readers),specificity 91% and Az value 0.95 for HCCs,84%,97%,and 0.95 for metastases,91%,98%,and 0.98 for hemangiomas and 80%,99%,and 0.99 for FNHs,respectively,while good to excellent inter-reader agreement was achieved.No significant difference exists between prospective diagnosis accuracy at CE 3D US and that at CE 2D US.CONCLUSION: CE 3D US provides a spatial perspective for liver tumor enhancement,and could help in differentiating focal liver lesions. | Kazushi Numata Manabu Morimoto Akito Nozaki Michio Ueda Masaaki Kondo Satoshi Morita Katsuaki Tanaka | 2010 | World Journal of Gastroenterology2010，16，17： | 12 |
| 4 | Successful initial ablation therapy contributes to survival in patients with hepatocellular carcinoma显示文摘AIM: To evaluate the outcome predictors of percu- taneous ablation therapy in patients with unresectable hepatocellular carcinoma (HCC), especially to identify whether the initial treatment response contributes to the survival of the patients. METHODS: The study cohort included 153 patients with single (102) and two or three (51) HCC nodules 5 cm or less in maximum diameter. As an initial treatment, 110 patients received radiofrequency ablation and 43 patients received percutaneous ethanol injection. RESULTS: The Kaplan-Meier estimates of overall 3- and 5-year survival rates were 75% and 59%, respectively. The log-rank test revealed statistically significant differences in the overall survivals according to Child- Pugh class (P = 0.0275), tumor size (P = 0.0130), serum albumin level (P = 0.0060), serum protein induced by vitamin K absence or antagonist Ⅱ level (P = 0.0486), and initial treatment response (P = 0.0130). The independent predictors of survival were serum albumin level (risk ratio, 3.216; 95% CI, 1.407-7.353; P = 0.0056) and initial treatment response (risk ratio, 2.474; 95% CI, 1.076-5.692; P = 0.0330) based on the Cox proportional hazards regression models. The patients had a serum albumin level 3.5 g/dL and the 3- and 5-year survival rates of 86% and 82%. CONCLUSION: In HCC patients treated with percutaneous ablation therapy, serum albumin level and initial treatment response are the independent outcome predictors. | Manabu Morimoto Kazushi Numata Kazuya Sugimori Kazuhito Shirato Atsushi Kokawa Hiroyuki Oka Kingo Hirasawa Ryonho Koh Hiromi Nihommatsu Katsuaki Tanaka | 2007 | World Journal of Gastroenterology2007，13，7： | 8 |
| 5 | Antithrombotic drugs are risk factors for delayed postoperative bleeding after endoscopic submucosal dissection for gastric neoplasms显示文摘 | Ryonho Koh Kingo Hirasawa Sei Yahara Hiroyuki Oka Kazuya Sugimori Manabu Morimoto Kazushi Numata Atsushi Kokawa Takeshi Sasaki Akinori Nozawa Masataka Taguri Satoshi Morita Shin Maeda Katsuaki Tanaka | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 6 | Evaluation of Humoral Immunity to Mycobacterium tuberculosis -Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development显示文摘 | Mamiko Niki Maho Suzukawa Shunsuke Akashi Hideaki Nagai Ken Ohta Manabu Inoue Makoto Niki Yukihiro Kaneko Kozo Morimoto Atsuyuki Kurashima Seigo Kitada Sohkichi Matsumoto Koichi Suzuki Yoshihiko Hoshino Pedro A. Reche | 2015 | Journal of Immunology Research2015，，： | 1 |
| 7 | Comparison of dose-response relations between 4-week inhalation and intratracheal instillation of NiO nanoparticles using polimorphonuclear neutrophils in bronchoalveolar lavage fluid as a biomarker of pulmonary inflammation显示文摘 | Yohei Mizuguchi Toshihiko Myojo Takako Oyabu Masayoshi Hashiba Byeong Woo Lee Makoto Yamamoto Motoi Todoroki Kenichiro Nishi Chikara Kadoya Akira Ogami Yasuo Morimoto Isamu Tanaka Manabu Shimada Kunio Uchida Shigehisa Endoh Junko Nakanishi | 2013 | Inhalation Toxicology2013，，1： | 1 |
| 8 | Role of Sonazoid-enhanced three-dimensional ultrasonography in the evaluation of percutaneous radiofrequency ablation of hepatocellular carcinoma显示文摘 | Wen Luo Kazushi Numata Manabu Morimoto Takashi Oshima Michio Ueda Masahiro Okada Shigeo Takebayashi Xiaodong Zhou Katsuaki Tanaka | 2009 | European Journal of Radiology2009，，1： | 1 |
| 9 | Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow显示文摘 | Sachiyo Kogita Yasuharu Imai Masahiro Okada Tonsok Kim Hiromitsu Onishi Manabu Takamura Kazuto Fukuda Takumi Igura Yoshiyuki Sawai Osakuni Morimoto Masatoshi Hori Hiroaki Nagano Kenichi Wakasa Norio Hayashi Takamichi Murakami | | European Radiology0，，： | 1 |
| 10 | Radiofrequency ablation in a pig liver model: effect of transcatheter arterial embolization on coagulation diameter and histologic characteristics显示文摘 | Kazuya Sugimori Manabu Morimoto Kazuhito Shirato Atsushi Kokawa Naohiko Tomita Takafumi Saito Akinori Nozawa Masamichi Hara Hisahiko Sekihara Katsuaki Tanaka | 2002 | Hepatology Research2002，，2： | 1 |
| 11 | Prediction of postoperative delirium after abdominal surgery in the elderly显示文摘 | Yasuhiro Morimoto Manabu Yoshimura Koji Utada Keiko Setoyama Mishiya Matsumoto Takefumi Sakabe | 2009 | Journal of Anesthesia2009，，1： | 1 |
| 12 | Extension of Radiofrequency Ablation of the Liver by Transcatheter Arterial Embolization with Iodized Oil and Gelatin Sponge: Results in a Pig Model显示文摘 | Kazuya Sugimori Akinori Nozawa Manabu Morimoto Kazuhito Shirato Atsushi Kokawa Toshifumi Saito Kazushi Numata Katsuaki Tanaka | 2005 | Journal of Vascular and Interventional Radiology2005，，6： | 1 |
| 13 | Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow显示文摘 | Sachiyo Kogita Yasuharu Imai Masahiro Okada Tonsok Kim Hiromitsu Onishi Manabu Takamura Kazuto Fukuda Takumi Igura Yoshiyuki Sawai Osakuni Morimoto Masatoshi Hori Hiroaki Nagano Kenichi Wakasa Norio Hayashi Takamichi Murakami | 2010 | European Radiology2010，，10： | 1 |
| 14 | Small hepatocellular carcinoma therapeutic effectiveness of percutaneous radio frequency ablation therapy with a Le Veen needle electrode 显示文摘 | KAZUHITO SHIRTO M D MANABU MORIMOTO M D NAOHIKO TOMITA M D | 2002 | Ultrasound Med2002，21，： | 1 |
| 15 | Effects of Charge Distribution in Thunderstorms on Lightning Propagation Paths in Darwin, Australia显示文摘 | Akita Manabu Yoshida Satoru Nakamura Yoshitaka Morimoto Takeshi Ushio Tomoo Kawasaki Zen Wang Daohong | 2011 | Journal of the Atmospheric Sciences2011，，4： | 1 |
| 16 | Treatment of hepatocellular carcinoma with radiofrequency ablation: Radiologic-histologic correlation during follow-up periods显示文摘 | Manabu Morimoto Kazuya Sugimori Kazuhito Shirato Atsushi Kokawa Naohiko Tomita Takafumi Saito Noriko Tanaka Akinori Nozawa Masamichi Hara Hisahiko Sekihara Hiroshi Shimada Toshio Imada Katsuaki Tanaka | 2002 | Hepatology2002，，6： | 1 |
| 17 | Prediction of postoperative delirium after abdominal surgery in the elderly显示文摘 | Yasuhiro Morimoto Manabu Yoshimura Koji Utada Keiko Setoyama Mishiya Matsumoto Takefumi Sakabe | 2009 | Journal of Anesthesia2009，，1： | 1 |
| 18 | Carbon dioxide insufflation is useful for obtaining clear images of the bile duct during peroral cholangioscopy (with video)显示文摘 | Toru Ueki Motowo Mizuno Shigeru Ota Tsuneyoshi Ogawa Hiroshi Matsushita Daisuke Uchida Norifumi Numata Asuka Ueda Yuuki Morimoto Yoko Kominami Shintaro Nanba Manabu Kurome Hirotoki Ohe Masahiro Nakagawa Yasuyuki Araki | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 19 | Influence of the water jet system vs cavitron ultrasonic surgical aspirator for liver resection on the remnant liver显示文摘BACKGROUND Several methods,such as finger fracture,Pean crush,cavitron ultrasonic surgical aspirator(CUSA),and water jet(WJ),are used for hepatic parenchymal dissection in liver surgery.CUSA is the conventional method in Japan.WJ is a relatively novel method for parenchymal dissection.Although it has several advantages,such as lower volume of blood loss and shorter operative time,the effect of the WJ system for hepatic dissection on the remnant liver has not yet been investigated.AIM To investigate and compare the effect of the WJ method vs CUSA on the remnant liver cut surface.METHODS This observational study compared the two types of parenchymal transection methods(WJ vs CUSA)in liver surgery.In total,24 and 40 patients who underwent hepatectomy using the WJ method and CUSA,respectively,were included in the analysis.Accordingly,the clinicopathological characteristics and clinical outcomes of 24 and 40 patients were compared.Furthermore,postoperative contrast-enhanced computed tomography(CT)scan was performed to assess the cut surface length of the remnant liver and the degenerative thickness of the areas with a reduced contrast effect in the dissected plane.Then,the two groups were compared.RESULTS On CT scan,the median areas of denaturation in the liver dissection planes were 522(range:109.5-1242)mm^(2) in the CUSA group and 324(range:93.6-1529)mm^(2) in the WJ group.The area did not significantly differ between the two groups;however,the denaturation thickness of the WJ group was significantly lower than that of the CUSA group[5.8(range:0.7-11.1)mm vs 3.3(range:1.7-10.4)mm,P<0.001].CONCLUSION The WJ group had significantly thinner contrast-enhanced areas in the post hepatectomy detached section than the CUSA group. | Takehiko Hanaki Ayumi Tsuda Teppei Sunaguchi Keisuke Goto Masaki Morimoto Yuki Murakami Kyoichi Kihara Tomoyuki Matsunaga Manabu Yamamoto Naruo Tokuyasu Teruhisa Sakamoto Toshimichi Hasegawa Yoshiyuki Fujiwara | 2022 | World Journal of Clinical Cases2022，10，20： | 0 |
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