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| 1 | High cardiovascular risk in pa- tients with Cushing' s syndrome according to 1999 WHO/ISH guide- lines 显示文摘 | Mancini T Kola B Mantero F | 2004 | Clin Endocrinol ( Oxf)2004，61，6： | 1 |
| 2 | Line broadening analysis of implosion core conditions at Z using argon K shell spectroscopy 显示文摘 | Burris-Mog T J Mancini R C Bailey J E | 2006 | Journal of Quantitative Spectroscopy and Radiation Transfer2006，99，13： | 1 |
| 3 | Treatment of Cushing disease: overview and recent findings 显示文摘 | Mancini T Porcelli T Giustina A | 2010 | Ther Clin Risk Manag2010，6，： | 1 |
| 4 | Two-echelon vehicle routing problem: A satellite location analysis显示文摘 | Crainic T G Perboli G Mancini S | 2010 | Procedia Social and Behavioral Science2010，2，3： | 1 |
| 5 | Investigation of ash deposit formation during co-firing of coal with sewage sludge,saw-dust and refuse derived fuel显示文摘 | Kupka T Mancini M Irmer M | 2008 | Fuel2008，87，12： | 1 |
| 6 | Transforming growth factor betal: implications in adrenocortical tumorigenesis 显示文摘 | Arnaldi G Freddi S Mancini T | 2000 | Endocr Res2000，26，4： | 1 |
| 7 | Antileukotriene drugs : clinical application, effectiveness and safety 显示文摘 | Riccioni G Bucciarelli T Mancini B | 2007 | Curr Med Chem2007，14，18： | 1 |
| 8 | Pre-hospital/emergencydepartment handover in Italy显示文摘 | Do jmi Di Delupis F Mancini N di Nota T | 2015 | Intern Emerg Med2015，10，1： | 1 |
| 9 | Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism显示文摘We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immunogenicity.In this study,we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod(a Toll-like receptor 7/8 agonist)covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase,α-mannosidase,or β-galactosidase.We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase.At a cellular level,we examined EDI metabolism across three cancer cell lines(B16 melanoma,TC2 prostate,and 4T1 breast cancer).Comparing the relative immunogenicity elicited by each EDI/cancer cell combination,we found that B16 cells produced the highest EDI prodrug immunogenicity,achieving>95% of that elicited by unmodified resiquimod,followed by TC2 and 4T1 cells(40% and 30%,respectively).Immunogenicity elicited was comparable for a given cell type and independent of the glycosidase substrate in the EDIs or differences in functional glycosidase activity between cell lines.Measuring drug efflux of the immunostimulant payload and efflux protein expression revealed that EDI/cancer cell-mediated immunogenicity was governed by efflux potential of the cancer cells.We determined that,following EDI conversion,immunostimulant efflux occurred through both P-glycoprotein-dependent and P-glycoprotein-independent transport mechanisms.Overall,this study highlights the broad ability of EDIs to couple immunogenicity to the metabolism of many cancers that exhibit drug efflux and suggests that designing future generations of EDIs with immunostimulant payloads that are optimized for drug efflux could be particularly beneficial. | Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini | 2020 | Acta Pharmacologica Sinica2020，41，7： | 1 |
| 10 | Cyclical Cushing's syndrome in a patieul with a bronchial neuroendocrine tumor (typical carcinoid ) expressing ghrelin and growth hormone secrelagogue receptors 显示文摘 | Arnahli G Arnaldi G Mancini T el al | 2003 | J Clin Endocrinol Metab2003，88，： | 1 |
| 11 | Role of endosomes in simian virus 40 entry and infection显示文摘 | Engel S Heger T Mancini R | | 0，，09： | 1 |
| 12 | Hyperprolactinemia and prolactinomas显示文摘 | Mancini T Casanueva FF Giustina A | | 0，，： | 1 |
| 13 | Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor(typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors显示文摘 | Arnaldi G Mancini T Kola B | 2003 | J Clin Endocrinol Metab2003，88，： | 1 |
| 14 | Chlamydophila pneumoniae,Mycoplasma pneumoniae,and influenza in children with respiratory infections in Alexandria,Egypt显示文摘 | Grassi T Mancini F Rezza G | 2014 | J Infect Dev Ctries2014，8，3： | 1 |
| 15 | Treatment of Cushing disease: overview and recent findings 显示文摘 | Mancini T Porcelli T Giustina A | 2010 | Ther Clin Risk Manag2010，6，： | 1 |
| 16 | High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines显示文摘 | Mancini T Kola B Mantero F | 2004 | Clin Endocrinol2004，61，6： | 1 |
| 17 | Specific vaccine therapy in chronic hepatitis B:induction of T cell proliferative responses specific for envelope antigens 显示文摘 | Couillin T Pol S Mancini M | 1999 | Infect Dis1999，180，： | 1 |
| 18 | High prevalence of radiological vertebral fractures in women with prolactin-secreting pituitary adenomas显示文摘 | Mazziotti G Mancini T Mormando M | | 0，，03： | 1 |
| 19 | Hyperprolactinemia and prolactinomas显示文摘 | Mancini T Casanueva FF Giustina A | 2008 | Endocrinol Metab Clin North Am2008，37，1： | 1 |
| 20 | Plasma lycopene and antioxidant vitamins in asthma: the PLAVA study 显示文摘 | Riccioni G Bucciarelli T Mancini B | 2007 | J Asthma2007，44，6： | 1 |
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