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| 1 | Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration显示文摘Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system,acting to mediate excitatory neurotransmission.However,high levels of glutamatergic input elicit excitotoxicity,contribut-ing to neuronal cell death following acute brain injuries such as stroke and trauma.While excitotoxic cell death has also been implicated in some neurodegenerative disease models,the role of acute apoptotic cell death remains controversial in the setting of chronic neurodegeneration.Nevertheless,it is clear that excitatory synaptic dysregula-tion contributes to neurodegeneration,as evidenced by protective effects of partial N-methyl-D-aspartate receptor antagonists.Here,we review evidence for sublethal excitatory injuries in relation to neurodegeneration associated with Parkinson’s disease,Alzheimer’s disease,amyotrophic lateral sclerosis and Huntington’s disease.In contrast to classic excitotoxicity,emerging evidence implicates dysregulation of mitochondrial calcium handling in excitatory post-synaptic neurodegeneration.We discuss mechanisms that regulate mitochondrial calcium uptake and release,the impact of LRRK2,PINK1,Parkin,beta-amyloid and glucocerebrosidase on mitochondrial calcium transporters,and the role of autophagic mitochondrial loss in axodendritic shrinkage.Finally,we discuss strategies for normalizing the flux of calcium into and out of the mitochondrial matrix,thereby preventing mitochondrial calcium toxicity and excitotoxic dendritic loss.While the mechanisms that underlie increased uptake or decreased release of mitochondrial calcium vary in different model systems,a common set of strategies to normalize mitochondrial calcium flux can prevent excitatory mitochondrial toxicity and may be neuroprotective in multiple disease contexts. | Manish Verma Britney N.Lizama Charleen T.Chu | 2022 | Translational Neurodegeneration2022，11，1： | 4 |
| 2 | Transarticular shear fractures of the distal humerus显示文摘 | Neil Ashwood Manish Verma Mark Hamlet Anand Garlapati Quentin Fogg | 2010 | Journal of Shoulder and Elbow Surgery2010，，1： | 3 |
| 3 | Plants Used as Antihypertensive显示文摘Hypertension is a critical health problem and worse other cardiovascular diseases.It is mainly of two types:Primary or essential hypertension and Secondary hypertension.Hypertension is the primary possibility feature for coronary heart disease,stroke and renal vascular disease.Herbal medicines have been used for millions of years for the management and treatment of hypertension with minimum side effects.Over aim to write this review is to collect information on the anti-hypertensive effects of natural herbs in animal studies and human involvement as well as to recapitulate the underlying mechanisms,from the bottom of cell culture and ex-vivo tissue data.According to WHO,natural herbs/shrubs are widely used in increasing order to treat almost all the ailments of the human body.Plants are the regular industrial units for the invention of chemical constituents,they used as immunity booster to enhance the natural capacity of the body to fight against different health prob-lems as well as herbal medicines and food products also.Eighty percent population of the world(around 5.6 billion people)consume medicines from natural plants for major health concerns.This review provides a bird’s eye analysis primarily on the traditional utilization,phytochemical constituents and pharmacological values of medicinal herbs used to normalize hypertension i.e.Hibiscus sabdariffa,Allium sativum,Andrographis paniculata,Apium graveolens,Bidenspilosa,Camel-lia sinensis,Coptis chinensis,Coriandrum sativum,Crataegus spp.,Crocus sativus,Cymbopogon citrates,Nigella sativa,Panax ginseng,Salviaemiltiorrhizae,Zingiber officinale,Tribulus terrestris,Rauwolfiaserpentina,Terminalia arjuna etc. | Tarawanti Verma Manish Sinha Nitin Bansal Shyam Raj Yadav Kamal Shah Nagendra Singh Chauhan | 2021 | Natural Products and Bioprospecting2021，11，2： | 2 |
| 4 | A cost and expected consequence approach to planning and managing railroad transportation of hazardous materials显示文摘 | Manish Verma | 2009 | Transportation Research Part D: Transport and Environment2009，14，5： | 1 |
| 5 | Tribological study of elastomeric bearings for marine propeller shaft system 显示文摘 | Hirani Harish Verma Manish | 2009 | Tribology International2009，42，： | 1 |
| 6 | A cost and expected consequence approach to planning and managing railroad transportation of hazardous materials显示文摘 | Manish Verma | 2009 | Transportation Research Part D:Transport and Environment2009，14，5： | 1 |
| 7 | A bi-objective model for planning and managing rail-truck intermodal transportation of hazardous materials显示文摘 | Manish Verma Vedat Verter Nicolas Zufferey | 2011 | Transportation Research Part E2011，，1： | 1 |
| 8 | Tribological study of elas-tomeric bearings for marine propeller shaft system 显示文摘 | Hirani Harish Verma Manish | 2009 | Tribology International2009，42，： | 1 |
| 9 | Railroad transportation of dangerous goods population exposure to airborne toxins显示文摘 | Manish Verma | 2004 | Computers Operations Research2004，，37： | 1 |
| 10 | Design and Inplementation of a CORBA Commodity Grid Kit显示文摘 | Snigdha Verma Manish Parashar Jarek Gawor | 2001 | Concurrency and Computation:Practice and Experience2001，07，： | 1 |
| 11 | Secure data aggregation in wireless sensor networks using homomorphic encryption显示文摘 | Manish Kumar Shekhar Verma Kusum Lata | 2015 | International Journal of Electronics2015，，4： | 1 |
| 12 | Tribological study of elastomer- ic bearings for marine propeller shaft system 显示文摘 | Hirani Harish Verma Manish | 2009 | Tribology International2009，42，2： | 1 |
| 13 | A highly sensitive SnO 2 –CuO multilayered sensor structure for detection of H 2 S gas显示文摘 | Manish Kumar Verma Vinay Gupta | 2012 | Sensors & Actuators: B Chemical2012，，： | 1 |
| 14 | A cost and expected consequence approach to planning and managing railroad transportation of hazardous materials显示文摘 | Verma Manish | 2009 | Transportation Research: Part D2009，14，5： | 1 |
| 15 | Tribological study of elastomeric bearings for marine propeller shaft system显示文摘 | Harish Hirani Manish Verma | 2009 | Tribology International2009，42，2： | 1 |
| 16 | Is mandible derived mesenchymal stromal cells superior in proliferation and regeneration to long bone-derived mesenchymal stromal cells?显示文摘Mesenchymal stromal cells(MSCs)are cells with the characteristic ability of self-renewal along with the ability to exhibit multilineage differentiation.Bone marrow(BM)is the first tissue in which MSCs were identified and BM-MSCs are most commonly used among various MSCs in clinical settings.MSCs can stimulate and promote osseous regeneration.Due to the difference in the development of long bones and craniofacial bones,the mandibular-derived MSCs(M-MSCs)have distinct differentiation characteristics as compared to that of long bones.Both mandibular and long bone-derived MSCs are positive for MSC-associated markers such as CD-73,-105,and-106,stage-specific embryonic antigen 4 and Octamer-4,and negative for hematopoietic markers such as CD-14. | Madhan Jeyaraman Tushar Verma Naveen Jeyaraman Bishnu Prasad Patro Arulkumar Nallakumarasamy Manish Khanna | 2023 | World Journal of Methodology2023，13，2： | 0 |
| 17 | Enhanced osseointegration of drug eluting nanotubular dental implants: An in vitro and in vivo study显示文摘Faster and predictable osseointegration is crucial for the success of dental implants, especially in patients with compromised local or systemic conditions. Despite various surface modifications on the commercially available Titanium (Ti) dental implants, the bioactivity of Ti is still low. Thus, to achieve both biological and therapeutic activity on titanium surfaces, surface modification techniques such as titanium nanotubes have been studied as nanotube surfaces can hold therapeutic drugs and molecules. The main aim of the present research work is to study the early osseointegration around the novel Simvastatin drug eluting nanotubular dental implant. In the present research, the titanium nanotubes were fabricated on the screw-shaped dental implant surface and the Simvastatin drug was loaded into the nanotubes using the ultrasonication dip method. In vitro and In vivo studies were carried out on the modified dental implants. In vitro cell culture study reported enhanced osteogenic activity on the drug-loaded nanotube surface implants. The in vivo animal studies were evaluated by micro-CT, histopathology, and reverse torque removal analysis methods. The test results showed faster osseointegration with the strong interface on the Simvastatin drug-loaded implant surface at 4 weeks of healing as compared to the control implants. | Pankaj Chauhan Alok Srivastava Pooja Bhati Manish Chaturvedi Vinay Patil Sriram Kunnoth Nisha Kumari Vedpal Arya Madhur Pandya Mohit Agarwal Smiti Bhardwaj Farrukh Faraz Sanjay Chauhan Mahesh Verma Veena Koul Naresh Bhatnagar | 2023 | Bioactive Materials2023，，10： | 0 |
| 18 | Serum paraoxonase activity and protein thiols in patients with hyperlipidemia显示文摘Objective: In the present study we evaluated the paraoxonase activity and protein thiols level in south Indian population with newly diagnosed hyperlipidemia.Methods: The study was conducted on 55 newly diagnosed hyperlipidemic patients and 57 healthy controls.Serum paraoxonase activity and protein thiols were estimated by spectrophotometeric method and lipid profile by enzymatic kinetic assay method.Results: Serum paraoxonase activity,protein thiols and high density lipoprotein levels were low and total cholesterol,triglycerides and low density lipoprotein levels were high in patients with hyperlipidemia compared to healthy controls(P<0.01).Serum paraoxonase activity correlated positively with protein thiols and high density lipoprotein(P<0.01).Conclusion: Decreased paraoxonase activity and protein thiols were found in patients with hyperlipidemia.This may indicate the susceptibility of this population to accelerated atherogenesis and protein oxidation. | Mungli Prakash Jeevan K Shetty Sudeshna Tripathy Pannuri Vikram Manish Verma | 2009 | 海南医学院学报2009，15，2： | 0 |
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