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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Comparison of 11 human insulin assays: implications for clinical investiga?tion and research显示文摘 | Manley S E Stratton 1M Clark PM | 2007 | Clin Chern2007，53，5： | 1 |
| 3 | Estimated average glucose derived from HbA1 C(eAG) : report from European Association for the Study of Diabetes ( EASD ), Amsterdam 2007 显示文摘 | Manley S | 2008 | Diabetic Medicine2008，25，： | 1 |
| 4 | Greatly impaired migration of implanted aquapor in-4-deficient astroglial cells in mouse brain toward a site of in jury显示文摘 | Auguste K I Jin S Uchida K Yan D Manley G T Papadopou los M C etal | 2007 | FASEB J2007，21，： | 1 |
| 5 | Effect of curcumin on a- cidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A) : role of PKC, MAPKs, and NF-kap- paB显示文摘 | Rafiee P Nelson VM Manley S | 2009 | Am J Physiol Gastrointest Liver Physiol2009，296，2： | 1 |
| 6 | The emerging role of autophagy in alcoholic liver disease显示文摘 | Ding WX Manley S Ni HM | 2011 | Exp Biol Med(Maywood)2011，236，5： | 1 |
| 7 | Haemoglobin A1c -a marker for complications of type 2 diabetes:the experience from the UK Prospective Diabetes Study (UKPDS)显示文摘 | Manley S | 2003 | Clin Chem Lab Med2003，41，9： | 1 |
| 8 | The role of stripe wear in causing a-coustic emissions from alumina ceramic-on-ceramic bearings显示文摘 | Taylor S Manley MT Sutton K | 2007 | J Arthroplasty2007，3，： | 1 |
| 9 | The effects of gamma irradiation on the microbiological,physical and sensory qualities of diced tomatoes显示文摘 | Prakash A Manley J DeCosta S | 2002 | Radiation Physics and Chemistry2002，63，： | 1 |
| 10 | Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema 显示文摘 | Papadopoulos MC Manley GT krishna S | 2004 | FASEB J2004，18，11： | 1 |
| 11 | Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain显示文摘 | Zador Z Magzoub M Jin S Manley G T Papadopoulos M C Verkman A S | 2008 | FASEB J2008，22，： | 1 |
| 12 | Aqua- porin- 4 facilitates reabsorption of excess fluid in vasogenic brain edema显示文摘 | Papadopoulos MC Manley GT Krishna S | 2004 | FASEB J2004，18，： | 1 |
| 13 | Aquaporin 4 facilitates reabsorption of excess fluid in vasogenic brain edema 显示文摘 | Papadopoulos MC Manley GT Krishhna S | 2005 | FASEB J2005，18，11： | 1 |
| 14 | Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema显示文摘 | Papadopoulos MC Manley GT Krishna S | 2004 | FASEB J2004，18，11： | 1 |
| 15 | The effects of gamma irradiation on the microbiological, physical and sensory qualities of diced tomatoes 显示文摘 | Prakash A Manley J Decosta S | 2002 | Radiation Physics and Chemistry2002，63，6： | 1 |
| 16 | The Emerging Role of Autophagy in Alcoholic Liver Disease显示文摘 | Ding W X Manley S Ni H M | 2011 | Exp Biol Med(Maywood)2011，236，5： | 1 |
| 17 | Aquaporin-4 facili-tates reabsorption of excess fluid in vasogenic brain edema显示文摘 | Papadopoulos MC Manley GT Krishrift S | 2004 | FASEB J2004，18，11： | 1 |
| 18 | Synthetic polymer-lignin copolymers and blend显示文摘 | WANG J S MANLEY R S FELDMAN D | 1992 | Prog Polym Sci1992，17，： | 1 |
| 19 | Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema 显示文摘 | Papadopoulos MC Manley GT Krishna S | 2004 | FASEB J2004，18，11： | 1 |
| 20 | 显示文摘 | Nishio Y Manley R S | 1988 | Macromolecules1988，21，： | 1 |
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