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| 1 | Alteration of compacted bentonite by diffusion of highly alkaline solutions显示文摘 | Raul Fernandez Urs K Mader Manuel Rodriguez | 2009 | European Journal of Mineralogy2009，21，4： | 1 |
| 2 | Activated carbons from sewage sludge: Application to aqueous-phase adsorp- tion of 4-chlorophenol 显示文摘 | Victor Manuel Monsalvo Angel Fernandez Mohe- dano Juan Jose Rodriguez | 2011 | Desalination2011，277，123： | 1 |
| 3 | Activated carbons from sewage sludge: Application to aqueous-phase adsorption of 4-chlorophenol 显示文摘 | Victor Manuel Monsalvo Angel Fernandez Mohedano Juan Jose Rodriguez | 2011 | Desalination2011，277，13： | 1 |
| 4 | Activated carbons from sewage sludge : Application to aqueous- phase adsorption of 4-chlorophenol显示文摘 | Victor Manuel Monsalvo Angel Fernandez Mohedano Juan Jose Rodriguez | 2011 | Desalination2011，8，： | 1 |
| 5 | Evaluation of Irrigation Projects and Water Resource Manage- ment: a Methodological Proposal 显示文摘 | Manuel Martin Rodriguez Francisco Javier Saez Fernandez | 2002 | Sustainable Develop- ment2002，，10： | 1 |
| 6 | Activated carbons from sewage sludge: application to aqueous-phase adsorption of 4-chlorophenol 显示文摘 | Victor Manuel Monsalvo Angel Fernandez Mohedano Juan Jose Rodriguez | 2011 | Desalination2011，277，13： | 1 |
| 7 | Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis显示文摘AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow up.RESULTS:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was more frequent in the TE than in the TN patients(57% vs 40%,P = 0.01). With respect to severe haematological disorders,neutropaenia was more likely to affect the patients treated with BOC(33% vs 20%,P ≤ 0.0001),and thrombocytopaenia and anaemia,the F4 patients(P = 0.000,P = 0.025,respectively). CONCLUSION:In a real clinical practice setting with a high proportion of patients with advanced fibrosis,effectiveness of first-generation PIs was high except for NR patients,with similar SVR rates being achieved by BOC and TVR. | Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria Navarro Milagros Testillano Conrado Fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles | 2015 | World Journal of Gastroenterology2015，21，30： | 0 |
| 8 | Recirculating chemohyperthermia as a treatment for non-muscle invasive bladder cancer:Current and future perspectives显示文摘About 75% of all bladder cancer diagnosed are non-muscle invasive bladder cancer(NMIBC), recurring over 50% of them after transurethral resection of the bladder tumor. In order to prevent recurrences, adjuvant intravesical chemotherapy with mitomycin C and immunotherapy with bacillus Calmette-Gu-érin(BCG) is traditionally used. Unfortunately, many patients relapse after receiving these treatments and a significant proportion of them require surgery. After a one-to-three years BCG maintenance, the risk for progression at 5 years was 19.3% for T1G3 tumors. Many new treatment approaches are being investigated to increase the effectiveness of adjuvant intravesical therapy. One of the developing treatments for intermediate and high-risk NMIBC is the combination of intravesical chemotherapy and hyperthermia, called chemohyperthermia. This article provides a review of the mechanism of action, current status and indications, results and future perspectives. | Javier Flores-Carbajal Alejandro Sousa-Escandón Daniel Sousa-Gonzalez Silvia Rodriguez Gomez Manuel Lopez Saavedra M Elia Fernandez Martinez | 2017 | World Journal of Clinical Urology2017，6，2： | 0 |
| 9 | Gastric inflammatory myofibroblastic tumor, a rare mesenchymalneoplasm: A case report显示文摘BACKGROUND The inflammatory myofibroblastic tumor(IMT)is a rare mesenquimal tumor of doubtful biological behaviour.It’s characterised for affecting mainly children and young adults,although it can appear at any age,being the lungs the primary affected organ(in children it represents 20%of all primary pulmonary tumors).CASE SUMMARY We present the case of a 45 year old woman,with a computed tomography(CT)finding of injury on the anterior surface of the fundus/gastric body and a solid perigastric injury of 12 mm in the ecoendoscopy.The case is presented in the tumor committee deciding to perform a laparoscopic wedge resection.The histological diagnosis was a IMT.The diagnosis is based on imaging tests like the abdominal CT,abdominal ecography and the ecoendoscopy but to confirm the diagnosis a pathological study is necessary.CONCLUSION Due to the unpredictable nature of this tumor,surgical resection is the best therapeutic option. | Manuel Fernandez Rodriguez Pedro Joaquin Artuñedo Pe Alejandro Callejas Diaz Gala Silvestre Egea Cristián Grillo Marín Eva Iglesias Garcia Jose Luis Lucena de La Poza | 2023 | World Journal of Gastrointestinal Surgery2023，15，11： | 0 |
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