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| 1 | Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis显示文摘AIM:To validate whether the platelet count/spleen size ratio can be used to predict the presence of esophageal varices in Mexican patients with hepatic cirrhosis.METHODS:This was an analytical cross-sectional study to validate the diagnostic test for hepatic cirrhosis and was performed between February 2010 and December 2011.Patients with a diagnosis of hepatic cirrhosis were included and stratified using their ChildPugh score.Biochemical parameters were evaluated,and ultrasound was used to measure the longest diameter of the spleen.The platelet count/spleen diameter ratio was calculated and analyzed to determine whether it can predict the presence of esophageal varices.Upper gastrointestinal endoscopy was used as the gold standard.Sensitivity and specificity,positive and negative predictive values,and positive and negative likelihood ratios were determined,with the cutoff points determined by receiver-operating characteristic curves.RESULTS:A total of 91 patients were included.The mean age was 53.75±12 years;50(54.9%)were men,and 41(45.0%)women.The etiology of cirrhosis included alcohol in 48(52.7%),virally induced in24(26.3%),alcoholism plus hepatitis C virus in three(3.2%),cryptogenic in nine(9.8%),and primary biliary cirrhosis in seven(7.6%).Esophageal varices were present in 73(80.2%)patients.Child-Pugh classification,17(18.6%)patients were classified as class A,37(40.6%)as class B,and 37(40.6%)as class C.The platelet count/spleen diameter ratio to detect esophageal varices independent of the grade showed using a cutoff value of≤884.3,had 84%sensitivity,70%specificity,and positive and negative predictive values of 94%and 40%,respectively.CONCLUSION:Our results suggest that the platelet count/spleen diameter ratio may be a useful tool for detecting esophageal varices in patients with hepatic cirrhosis. | Alejandro González-Ojeda Gabino Cervantes-Guevara Manuela Chávez-Sánchez Carlos Dávalos-Cobián Susana Ornelas-Cázares Michel Dassaejv Macías-Amezcua Mariana Chávez-Tostado Kenia Militzi Ramírez-Campos Anaís del Rocío Ramírez-Arce Clotilde Fuentes-Orozco | 2014 | World Journal of Gastroenterology2014，20，8： | 18 |
| 2 | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients显示文摘The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant.However,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense debate.The start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body.This variability seems to be correlated with the presence of genetic polymorphisms.Genotyping is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given gene.However,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that medication.At present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of tacrolimus.However,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and toxicity.For these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing. | Alessio Provenzani Andrew Santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra Provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 3 | 显示文摘 | Manuela H B Francoise E D | 2001 | Carbon2001，39，： | 1 |
| 4 | Antiproliferative and antioxidant effects on breast cancer cells of oleuropein and its semisynthetic peracetylated derivatives显示文摘 | Stefania Bulotta Rosanna Corradino Marilena Celano Maria D’Agostino Jessica Maiuolo Manuela Oliverio Antonio Procopio Michelangelo Iannone Domenicantonio Rotiroti Diego Russo | 2011 | Food Chemistry2011，，4： | 1 |
| 5 | Outer product analysis of electronic nose and visible spectra: application to the measurement of peach fruit characteristics显示文摘 | Corrado Di Natale Manuela Zude-Sasse Antonella Macagnano Roberto Paolesse Bernd Herold Arnaldo D’Amico | 2002 | Analytica Chimica Acta2002，，1： | 1 |
| 6 | Plasmid-mediated iron uptake and virulence in Vibrio anguillarum 显示文摘 | Michiel S Manuela D L Timothy J | 2002 | Plasmid2002，48，： | 1 |
| 7 | A case - control study on bovine tuberculosis in the Veneto Region Italy 显示文摘 | Stefano M Marco M Manuela D P | 2008 | Preventive Veterinary Medicine2008，34，： | 1 |
| 8 | Iron overload and heart fibrosis in mice deficient for both β2- microglobulin and Ragl 显示文摘 | MANUELA M S MARIA D S LUKE H P | 2000 | Am J Pathol2000，157，6： | 1 |
| 9 | SBAS-based satellite orbit correction for the generation of DInSAR timeseries:application to RADARSAT-1 data显示文摘 | PEPE A BERARDINO P MANUELA B LEONARDO D E LANARI R SANSOSTI E | 2011 | IEEE2011，49，12： | 1 |
| 10 | Functional properties of peptides obtained from whey proteins by ficin extract hydrolysis显示文摘Enzymatic whey proteins concentrates (WPC) hydrolysis under optimal conditions of ficin crude extract (FCE) in two ratios E/S (0.5 and 1%) was studied,assessing the impact of hydrolysis on WPC by determination degree of hydrolysis (DH),Fast proteins liquid chromatography (FPLC),Tricine SDS-PAGE,antioxidant activity at sampling time beside,and technological properties (solubility,emulsifying activity index (EAI) and foaming activity (FA)) at the best condition (maximum DH and antioxidant activity) other side.Results showed,in the first 30 min,DH reached 22.76% at E/S (1%) with a total degradation of α-lactalbumin (α-La) and almost of β-lactoglobulin (β-Lg).A significant increase in antioxidant activity and solubility was observed,while not for EAI,and FA.These results indicate for the first time that β-Lg is susceptible to hydrolyse by FCE that rarely found for other enzymes.Ficin hydrolysates showed very relevant performance,and suggest that could be appropriate production of functional ingredients. | Afaf Kheroufi María E.Brassesco Débora A.Campos Halima Boughellout Manuela E.Pintado | 2022 | Food Bioscience2022，47，3： | 1 |
| 11 | Proteolysis in dry fermented sausages:The effect of selected exogenous proteases显示文摘 | Olga D Manuela F Gonzalo D | 1997 | Meat Science1997，46，1： | 1 |
| 12 | Evidence that N-acetylcysteine inhibits TNF-α-induced cerebrovascularen-dothelin-1 up regulation via inhibition of mitogen-andstress-activated protein kinase显示文摘 | MATTHIAS D MANUELA F MIRANDA K | 2006 | Free Radic BiolMed2006，41，： | 1 |
| 13 | Sensitivity of Chlamydia suis to cathelicidin peptides显示文摘 | MANUELA D ANTONIETTA D F RENATO G | 2007 | Vet Mi-crobiol2007，123，11： | 1 |
| 14 | The influence of leaf water content and isoprenoids on flammability of some Mediterranean woody species显示文摘 | Manuela D L Pietro M B Francesco L | | 0，，02： | 1 |
| 15 | Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes显示文摘 | Oliver Soehnlein Maik Drechsler Yvonne D?ring Dirk Lievens Helene Hartwig Klaus Kemmerich Almudena Ortega‐Gómez Manuela Mandl Santosh Vijayan Delia Projahn Christoph D. Garlichs Rory R. Koenen Mihail Hristov Esther Lutgens Alma Zernecke Christian Weber | 2013 | EMBO Mol Med2013，，3： | 1 |
| 16 | Correlation Between Nitrate Concentration in Groundwater and Parameters Affecting Aq- uifer Intrinsic Vulnerability显示文摘 | Laura D Domenico L Manuela L | 2008 | Environment Geology2008，55，3： | 1 |
| 17 | Anemia in diffuse large B-cell non-Hodgkin lymphoma: the role of interleukin-6, hepcidin and erythropoietin显示文摘 | Maria Chiara Tisi Valentina Bozzoli Manuela Giachelia Giuseppina Massini Bianca Maria Ricerca Elena Maiolo Francesco D&rsquo Alo&rsquo Luigi Maria Larocca Alfonso Piciocchi Harold Tjalsma Dorine W. Swinkels Maria Teresa Voso Giuseppe Leone Stefan Hohaus | 2014 | Leukemia & Lymphoma2014，，2： | 1 |
| 18 | The Journal of Clinical Endocrinology显示文摘 | Manuela D George J Kahaly B | 2002 | Metabolism2002，88，7： | 1 |
| 19 | Synergism and postantibiotic effect of tobramycin and Melaleuca alternifolia(tea tree)oil against Staphylococcus aureus and Escgerichia coli显示文摘 | Manuela D Giovanna G Giuseppina M | 2010 | Phytomedicine2010，17，5： | 1 |
| 20 | Proteolysis in Dry Fermented Sausage:The Effect of Seleted Exogenous Proteases 显示文摘 | Olga Diaz Manuela Fernandez Gonzalo D Garcia De Fernando | 1997 | Meat Science1997，46，1： | 1 |
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