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| 1 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 2 | Estrogenic and antiproliferative ac- tivities of isoliquiritigenin in MCF7 breast cancer cells显示文摘 | Marcello M Giancarlo S Adele V | 2002 | The Journal of Steroid Biochemistry and Molecular Biology2002，82，45： | 1 |
| 3 | The PPE Domain of PPE17 Is Responsible for Its Surface Localization and Can Be Used to Express Heterologous Proteins on the Mycobacte- rial Surface显示文摘 | Valentina D Marcello V Michela S | 2013 | PLoS One2013，8，57： | 1 |
| 4 | MEGAP impedes ce-ll migration via regulating actin and microtubule dynamics and focal complex formation显示文摘 | YANG Y MARCELLO M ENDRIS V | 2006 | Exp Cell Res2006，312，： | 1 |
| 5 | Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells 显示文摘 | Marcello M Giancarlo S Adele V | 2002 | Journal of Steroid Biochemistry & Molecular Biology2002，82，4： | 1 |
| 6 | Probabilistic ecological risk assessment of 1,2,4-trichlorobenzene at a former industrial contaminated site显示文摘 | Marcello Z Claudia C Jose V T | 2005 | Environmental Science and Technology2005，39，9： | 1 |
| 7 | Development of mod- els and detection methods for different forms of eytomegalovirus for the evaluation of viral inactivation agents 显示文摘 | Jayarama V Marcello J Ohagen A | 2006 | Transfusion2006，46，9： | 1 |
| 8 | The delay & sum algorithm applied to microphone array measurements:numerical analysis and experimental validation显示文摘 | ALFREDO C RIPAMONTI F MARCELLO V | | 0，，： | 1 |
| 9 | MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice显示文摘 | Zhang Denghong Contu Riccardo Latronico Michael V G Zhang Jian Ling Rizzi Roberto Catalucci Daniele Miyamoto Shigeki Huang Katherine Ceci Marcello Gu Yusu Dalton Nancy D Peterson Kirk L Guan Kun-Liang Brown Joan Heller Chen Ju Sonenberg Na | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
| 10 | Hepatic Steatosis Is Associated With Aortic Valve Sclerosis in the General Population: The Study of Health in Pomerania (SHIP)显示文摘 | Marcello Ricardo Paulista Markus Sebastian Edgar Baumeister Jan Stritzke Marcus D?rr Henri Wallaschofski Henry V?lzke Wolfgang Lieb | 2013 | Arteriosclerosis Thrombosis and Vascular Biology2013，，7： | 1 |
| 11 | Local and global agglomeration pat- terns: Two econometrics- based indicators 显示文摘 | GIACINTO V D MARCELLO P | 2011 | Regional Science and Urban Economics2011，，41： | 1 |
| 12 | International guidelines on mercury management in small-scale gold mining显示文摘 | Samuel J S Marcello M V | 2010 | Journal of Cleaner Production2010，18，4： | 1 |
| 13 | A prototype of a fuel cell PEM emulator based on a buck converter 显示文摘 | GIUSEPPE M MARCELLO P G1ANPAOLO V | 2009 | Applied Energy2009，86，10： | 1 |
| 14 | Simultaneous analysis of first - line anti - tuberculosis drugs in tab- lets by UV spectrophotometry compared to capillary zone electrophoresis 显示文摘 | Marcellos L F de Souza M V N Almeida M R | 2012 | Central European Journal of Chemistry2012，，10： | 1 |
| 15 | A configurable reference modeling language 显示文摘 | Marcello R Wil V D A | 2007 | Information Systems2007，32，1： | 1 |
| 16 | Collective work and resilience of complex systems显示文摘 | Mario C R Vidal Paulo V R Carvalho Marcello S Santos | | 0，，22： | 1 |
| 17 | The delay & sum algorithm applied to microphone array measurements:numerical analysis and experimental validation显示文摘 | Alfredo C Ripamonti F Marcello V | 2007 | Mechanical Systems and Signal Processing2007，21，： | 1 |
| 18 | Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study) * * The views expressed here are those of the authors and do not necessarily reflect those of the Indian Health Service.显示文摘 | Marcello Chinali Richard B Devereux Barbara V Howard Mary J Roman Jonathan N Bella Jennifer E Liu Helaine E Resnick Elisa T Lee Lyle G Best Giovanni de Simone | 2004 | The American Journal of Cardiology2004，，1： | 1 |
| 19 | A single-phase DG generation unit with shunt active power filter capability by a- daptive neural filtering 显示文摘 | MAURIZIO C MARCELLO P GIANPAOLO V | 2008 | IEEE Transactions on Industrial Elec- tronics2008，55，5： | 1 |
| 20 | Long-term se-quential deferiprone-deferoxamine versus deferiprone alone forthalassaemia major patients : A randomized clinical trial 显示文摘 | AURELIO M ANGELA V MARCELLO C | 2009 | Br JHaematol2009，145，2： | 1 |
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