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| 1 | 现场快速评估在纤维支气管镜活检中的应用研究显示文摘目的探讨纤维支气管镜活检结合细胞学现场快速评估(ROSE)对肺部中央型肿块诊治的临床价值。方法选取2016年6月-2017年12月昆明医科大学第三附属医院云南省肿瘤医院胸外一科收治的110例胸部CT或PET-CT检查提示中央型肺部肿块的患者分为2组,行纤维支气管镜活检,其中现场细胞学组58例,常规细胞学组52例。术后对2组患者所取的组织或体液均行常规细胞学及组织学病检,必要时行免疫组化协助诊断。将确诊为肺恶性肿瘤病例,行术后基因检测。结果现场细胞学组与非现场细胞学组的确诊率分别为82.76%、82.70%,一致性kappa大于0.8,现场细胞学与常规细胞学诊断符合率高度一致;首次活检时间分别为(18.92±1.63)min、(11.48±0.886)min,差异有统计学意义(P<0.001)。二次检查率分别为3.44%,17.30%(P<0.05),差异有统计学意义。活检出血发生率分别为2.13%、4.85%,差异无统计学意义(P>0.05)。现场细胞学组肺恶性肿瘤标本行术后基因检测EGFR基因突变8例,ALK基因突变1例。常规细胞学组因组织有限,仅有1例肺恶性肿瘤标本行基因检测,未发现基因突变。结论纤维支气管镜活检结合快速现场评估(ROSE)在肺部中央型肿块诊疗中,缩短了诊治时间,是有效且可靠的技术;针对术中ROSE技术提示病变组织部位,可获取更多组织用于术后免疫组化及基因检测,值得临床推广应用。 | 黄秋博 Giuseppe Marciano 胡早秀 谭慧 晋萍 张磊 黄云超 赵光强 | 2018 | 云南医药2018，39，2： | 10 |
| 2 | Imatinib-induced fatal acute liver failure显示文摘Imatinib mesylate is a drug that has been approved for treatment of chronic myeloid leukemia (CML) in blast crisis, accelerated or chronic phase, and also for advanced gastrointestinal stromal tumors. Severe hepatic toxicity and three deaths from hepatic failure have been reported. We report the case of a 51-year-old woman who was admitted to our institution with severe acute hepatitis. She was diagnosed with CML and began treatment with imatinib mesylate at a dose of 400 mg/d. Five months after beginning treatment, she developed severe hepatitis associated with coagulopathy, and was admitted to our institution. She had been consuming acetaminophen 500-1000 mg/d after the onset of symptoms. She had a progressive increase in bilirubin level and a marked decrease of clotting factor Ⅴ. Five days after admission, grade Ⅱ encephalopathy developed and she was referred for liver transplantation. Her clinical condition progressively deteriorated, and 48 h after being referred for transplantation she suffered a cardiac arrest and died. This report adds concern about the possibility of imatinib-mesylate-induced hepatotoxicity and liver failure, particularly in the case of concomitant use with acetaminophen. Liver function tests should be carefully monitored during treatment and, with the appearance of any elevation of liver function tests, treatment should be discontinued. | Ezequiel Ridruejo Roberto Cacchione Alejandra G Villamil Sebastián Marciano Adrián C Gadano Oscar G Mandó | 2007 | World Journal of Gastroenterology2007，13，48： | 5 |
| 3 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 4 | Intermediate-advanced hepatocellular carcinoma in Argentina:Treatment and survival analysis显示文摘BACKGROUND Hepatocellular carcinoma(HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of HCC.AIM To describe real-life treatments performed in patients with intermediateadvanced HCC before the approval of new systemic options.METHODS This longitudinal observational cohort study was conducted between 2009 and2016 in 14 different regional hospitals from Argentina. Included subjects had intermediate-advanced Barcelona Clinic Liver Cancer(BCLC) HCC stages(BCLC B to D). Primary end point analyzed was survival, which was assessed for each BCLC stage from the date of treatment until last patient follow-up or death.Kaplan Meier survival curves and Cox regression analysis were performed, with hazard ratios(HR) calculations and 95% confidence intervals(95%CI).RESULTS From 327 HCC patients, 41% were BCLC stage B, 20% stage C and 39% stage D.Corresponding median survival were 15 mo(IQR 5-26 mo), 5 mo(IQR 2-13 mo)and 3 mo(IQR 1-13 mo)(P < 0.0001), respectively. Among BCLC-B patients(n =135), 57% received TACE with a median number of 2 sessions(IQR 1-3 sessions).Survival was significantly better in BCLC-B patients treated with TACE HR =0.29(CI: 0.21-0.40) than those without TACE. After tumor reassessment by RECIST 1.1 criteria following the first TACE, patients with complete response achieved longer survival (HR = 0.15(CI: 0.04-0.56, P = 0.005))Eighty-two patients were treated with sorafenib, mostly BCLC-B and C(87.8%). However,12.2% were BCLC-D. Median survival with sorafenib was 4.5 mo(IQR 2.3-11.7 mo);which was lower among BCLC-D patients 3.2 mo(IQR 2.0-14.1 mo). A total of 36 BCLC-B patients presented tumor progression after TACE. In these patients,treatment with sorafenib presented better survival when compared to those patients who received sorafenib without prior TACE [HR = 0.26(CI: 0.09-0.71);P= 0.013].CONCLUSION In this real setting, our results were lower than expected. This highlights unmet needs in Argentina, prior to the introduction of new treatments for HCC. | Federico Pinero Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Gustavo Romero Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2019 | World Journal of Gastroenterology2019，25，27： | 3 |
| 5 | Effects of converting enzyme inhibition on heart period variability in patients with acute myocardial infarction显示文摘 | BONADUCE D MARCIANO F PETRETTAM | 1994 | Circulation1994，90，1： | 2 |
| 6 | Long-term interfer- on gamma therapy for patients with chronic granulomatous dis- ease 显示文摘 | Marciano BE Wesley R De Carlo ES | 2004 | Clin Infect Dis2004，39，： | 1 |
| 7 | Pharmacologic manage ment of spinal cord injury:Review of the literature显示文摘 | Marciano FF Greene KA Apostolides PJ | 1995 | BNIQ1995，11，： | 1 |
| 8 | WHO disability grade does not influence physical activity in Brazilian leprosy patients 显示文摘 | Do Prado GD Prado RB Marciano LH | 2011 | Lepr Rev2011，82，3： | 1 |
| 9 | LPS induces the interactionofatranscriptionfactor,LPS-induced TNF-alpha factor,and STAT6(B) with effects on multiple cytokines显示文摘 | Tang X Marciano DL Leeman SE | | 0，，： | 1 |
| 10 | Com- mon severe infections in chronic granulomatous disease 显示文摘 | Marciano B E Spalding C Fitzgerald A | 2014 | Clin Infect Dis2014，，： | 1 |
| 11 | Oxalic acid, cell wall - degrading enzymes and pH in pathogenesis and their significance in the virulence of two Sclerotinia sclerotiorum isolates on sunflower 显示文摘 | Marciano P Lenna P D Magro P | 1983 | Physiol Plant Pathol1983，22，： | 1 |
| 12 | Cardiopulmonary bypass, hypothermic circulatory arrest and barbiturate cerebral protection for the treatment of giant vertebrobasilar aneurysms in children显示文摘 | Marciano F F Hamilton M G | 1994 | Pediatr Neurosurg1994，21，2： | 1 |
| 13 | Is fusion indicated of I,umbar spinal disorders 显示文摘 | Sonntag VK Marciano FF | 1995 | Spine1995，20，24： | 1 |
| 14 | Relapse rates in chronic hepatitis B na?ve patients after discontinuation of antiviral therapy with entecavir显示文摘 | E. Ridruejo S. Marciano O. Galdame M. V. Reggiardo A. E. Mu?oz R. Adrover D. Cocozzella N. Fernandez C. Estepo M. Mendizábal G. A. Romero D. Levi T. Schroder S. Paz H. Fainboim O. G. Mandó A. C. Gadano M. O. Silva | 2014 | J Viral Hepat2014，，8： | 1 |
| 15 | Evaluation of small intestine bacterial overgrowth in patients with func- tional dyspepsia through H2 breath test显示文摘 | Costa MB Azeredo IL Jr Marciano RD | 2012 | Arq Gastroenterol2012，49，4： | 1 |
| 16 | Acute axis fractures:analysis of management outcome in 340 consecutive cases显示文摘 | Greene KA Dickman CA Marciano FF | 1997 | Spine1997，22，16： | 1 |
| 17 | Acute axis fractures: analysis of management and outcome in 340 consecutive cases显示文摘 | Greene KA Dickman CA Marciano FF | 1997 | Spine1997，22，16： | 1 |
| 18 | Effects of converting enzyme inhibition on heart period variability in patients with acute myocardial infarction显示文摘 | Bonaduce D Marciano F Petretta M | 1994 | Circulation1994，90，： | 1 |
| 19 | Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss显示文摘 | Fortunato G Marciano E Zarrilli F | 2004 | Clin Chem2004，50，11： | 1 |
| 20 | LPS induces the interaction of a transcription factor, LPS-induced TNF-α factor, and STAT6(B) with effects on multiple cytokines显示文摘 | TANG X R MARCIANO D L LEEMAN S E | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，14： | 1 |
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