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| 1 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 2 | Assessing Drought Vulnerability of Bulgarian Agriculture through Model Simulations显示文摘 | Zomitsa Popova Maria Ivanova Luis Santos Pereira Vesselin Alexandrov Katerina Doneva Petra Alexandrova Milena Kercheva | 2012 | Journal of Environmental Science and Engineering(B)2012，1，8： | 2 |
| 3 | NMR study of the supramoleeular structure of dual drug-loaded poly(butylcyanoaerylate) nanopartieles显示文摘 | Margarita Simeonova Maria Rangel Galya Ivanova | 2013 | PCCP2013，15，16： | 1 |
| 4 | Hegemony and Seigniorage显示文摘 | Ivanova Maria N | 2010 | International Journal of Political Economy2010，39，1： | 1 |
| 5 | Effects of cigarette smoking on sperm plasma membrane integrity and DNA fragmen- tation 显示文摘 | Antoaneta Belcheva Maria Ivanova - kicheva Petia Tzvetkova | 2004 | International Journal of Andrology2004，27，5： | 1 |
| 6 | 'International Environmental Governance Reform: Options and Implications '显示文摘 | Maria Ivanova | 2007 | Royal Institute of International Affairs2007，，： | 1 |
| 7 | Religious Narratives and Religious Coping Strategies in the Context of COVID-19 Pandemic显示文摘Recent findings demonstrate a growing interest in religiosity during the COVID-19 pandemic and suggest that religiousness has a Janus-face impact on coping with stress.On the one hand,the empirical data indicates a positive link between religiosity and mental health,agreeableness,and higher emotion regulation skills.On the other side,some surveys describe religious people as being reluctant to follow the recommendation of public health experts,and they also tend to score lower on intelligence and analytic thinking measures.However,how religiosity in our country impacts psychological processes of perception and coping with stress during the pandemic is not studied yet.The research reveals religious views on the COVID-19 pandemic through the analysis of semi-structured interviews with believers from different Bulgarian religious communities—Orthodox Christians,Catholics,Protestants,and Muslims.The focus of the one religious interpretation is pandemic as retribution for the self-forgetfulness of a man and the consumerist attitude towards God’s creation.The main narrative in the other interpretation considers diseases and suffering that accompany human life as a natural consequence of original sin and perishable human nature.Both points of view relate to various coping methods with challenges during the COVID-19 pandemic. | Maria Ivanova | 2022 | Cultural and Religious Studies2022，10，10： | 0 |
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