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| 1 | Bile acids:Chemistry,physiology,and pathophysiology显示文摘The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physical-chemical and biological characteristics.They are synthesized by the liver from cholesterol through several complementary pathways that are controlled by mechanisms involving finetuning by the levels of certain bile acid species.Although their best-known role is their participation in the digestion and absorption of fat,they also play an important role in several other physiological processes.Thus,genetic abnormalities accounting for alterations in their synthesis,biotransformation and/or transport may result in severe alterations,even leading to lethal situations for which the sole therapeutic option may be liver transplantation.Moreover,the increased levels of bile acids reached during cholestatic liver diseases are known to induce oxidative stress and apoptosis,resulting in damage to the liver parenchyma and,eventually,extrahepatic tissues.When this occurs during pregnancy,the outcome of gestation may be challenged.In contrast,the physical-chemical and biological properties of these compounds have been used as the bases for the development of drugs and as pharmaceutical tools for the delivery of active agents. | Maria J Monte Jose JG Marin Alvaro Antelo Jose Vazquez-Tato | 2009 | World Journal of Gastroenterology2009，15，7： | 36 |
| 2 | Excretion of biliary compounds during intrauterine life显示文摘In adults,the hepatobiliary system,together with the kidney,constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine,respectively.However,during intrauterine life the biliary route of excretion for cholephilic compounds,such as bile acids and biliary pigments,is very poor.Although very early in pregnancy the fetal liver produces bile acids,bilirubin and biliverdin,these compounds cannot be efficiently eliminated by the fetal hepatobiliary system,owing to the immaturity of the excretory machinery in the fetal liver.Therefore,the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta.Owing to the presence of detoxifying enzymes and specifi c transport systems at different locations of the placental barrier,such as the endothe-lial cells of chorionic vessels and trophoblast cells,this organ plays an important role in the hepatobiliary-like function during intrauterine life.The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother.This may result in oxidative stress and apoptosis,mainly in the placenta and fetal liver,which might affect normal fetal development and challenge the fate of the pregnancy.The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. | Rocio IR Macias Jose JG Marin Maria A Serrano | 2009 | World Journal of Gastroenterology2009，15，7： | 6 |
| 3 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 4 | Long-term Outcome of Bilateral Lung Volume Reduction in 250 Consecutive Patients with Emphysema显示文摘 | Anna Maria Ciccone Bryan FM Tracey JG | 2003 | J Thorac Cardiovasc Surg2003，125，3： | 1 |
| 5 | Transvaginal col or dopp ler sonography versus sonohyster ography in the diagno2 sis of endometrial polyps显示文摘 | Juan LA Maria JG Jose AM | 2004 | Ultrasound2004，23，6： | 1 |
| 6 | HACCP and water safety plans in Icelandic watersupply : preliminary evaluation of experience 显示文摘 | Maria JG Loftur RG | 2008 | J Water Health2008，6，： | 1 |
| 7 | Effect of experimental diabetes on mandible growth in rats显示文摘 | Maria AL | 2001 | Eur J Oral Sci2001，109，3： | 1 |
| 8 | Hypermethylation of P16ink4a and P15ink4b genes as a marker of disease in the follow-up of non-Hodgkin's lymphomas显示文摘 | Beatriz MD Alberto R Maria JG | 2000 | Br J Haematol2000，109，： | 1 |
| 9 | Transvaginal colordoppler sonography versus sonohysterography in the diagnosis of endometri- al polyps显示文摘 | Juan LA Maria JG JoseAM | 2004 | Ultrasound2004，23，6： | 1 |
| 10 | Essential hypertension and histocompatibility antigens 显示文摘 | Maria GD Maria AL Jose JG | 1992 | Hypertension1992，19，： | 1 |
| 11 | Transvaginal color doppler sonography versus sonohysterography in the diagnosis of endometrial polyps显示文摘 | Juan LA Maria JG Jose AM | 2004 | Ultrasound2004，23，： | 1 |
| 12 | Transvaginal color doppler sonography versus sonohysterography in the diagnosis of endometrial polyps 显示文摘 | Juan LA Maria JG Jose AM | 2004 | Ultrasound2004，23，6： | 1 |
| 13 | A human hepatocellular in vitro model to investigate steatosis显示文摘 | MARIA JG MARIA TD ALICIA MR | 2007 | Chemical-biological inaction2007，165，： | 1 |
| 14 | Effect of experimental diabetes on mandible growth in rats显示文摘 | Ma(A)ximo JG Maria AL | 2001 | Eur J Oral Sci2001，109，3： | 1 |
| 15 | Dipyridamole-induced increase in production of rat dopaminergic neurons from mesencephalic precursors 显示文摘 | Jannette RP Hector JC Maria JG | 2002 | Neurosci Lett2002，320，1： | 1 |
| 16 | Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver显示文摘 | Cripps JG Wang J Maria A | 2010 | Hepatology2010，52，4： | 1 |
| 17 | Multiple positional nystagmus suggests multiple canal involvement in benign paroxysmal positional vertigo显示文摘 | Jose AL Maria IM Maria JG | 2005 | Acta Oto- Laryngologica2005，125，： | 1 |
| 18 | G2019S Dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort显示文摘 | Jose MB Rita JG Maria HR | 2005 | Mov Disord2005，20，12： | 1 |
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