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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Chemical factors for chemical-mechanical and electrochemical mechanical planarization of silver examined using potentiodynamic and impedance measurements 显示文摘 | SAMUEL B E JENNIFER L H MARIA A D | 2005 | Materials Chemistry and Physics2005，89，23： | 1 |
| 3 | IL-18 Enhances IL-4 production by ligand-activated NKT lymphocytes:a Pro-Th2 effect of IL-18 exerted through NKT cells显示文摘 | AGATHE H MARIA P | 2001 | J Immunol2001，166，： | 1 |
| 4 | Photoelectro-chemical degradation of naphthol blue-black diazo dye on WO3 film electrode显示文摘 | Jin L Maria H | 2001 | Electrochimica Acta2001，46，15： | 1 |
| 5 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 6 | Identification of Candida albicans exposed surface proteins in vivo by a rapid proteomic approach 显示文摘 | Maria L H Pilar X E Montserrat M G | 2010 | Proteomics2010，73，7： | 1 |
| 7 | Effect of olfactory stimula- tion during suckling on agonistic behavior in weaned pigs显示文摘 | Maria F Julio O Maria L H | 2012 | J Swine Health Prod2012，20，1： | 1 |
| 8 | Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells显示文摘 | Héléne FD Olivier G Maria MM | 2002 | Carcinogenesis2002，23，8： | 1 |
| 9 | Virulence factors of Vibrio metschnikovii strains isolated from fish in Brazil显示文摘 | MARIA H M LUCIA B MARIA L B | 2007 | Food Control2007，18，6： | 1 |
| 10 | Long- term changes in summer phytoplankton communities of the open northern Baltic Sea 显示文摘 | Sanna S Maria L Maija H | 2006 | Estuarine Coastal and Shelt Science2006，71，34： | 1 |
| 11 | Safety and Tolerability of Montelukast in Placebo-Controlled Pediatric Studies and Their Open-Label Extensions显示文摘 | Bisgaard H David S Maria L B | 2009 | Pediatr Pulmonology2009，44，： | 1 |
| 12 | Anti-ulcergenic activity of xanthanolide sesquiterpenes from Xanthium cavaniUesii in rats显示文摘 | Favier L S Maria A O M Wendel G H | 2005 | J Ethnopharmacol2005，100，3： | 1 |
| 13 | Autoimmune pancreatitis:an underdiagnosed autoimmune disease with clinical, imaging and serological features 显示文摘 | Maria S Gonzalo H Marcos L | 2010 | Autoimrnunity Reviews2010，9，4： | 1 |
| 14 | Modulation of the antioxidant system in citrus under waterlogging and subsequent drainage显示文摘 | Zahed H Maria F L Vicent A | 2009 | Plant Physiol2009，166，： | 1 |
| 15 | Long-term changes in summer phytoplankton communities of the open northern Baltic Sea显示文摘 | Sanna S Maria L Maua H | 2006 | Estuarin Coastal and Shelf Science2006，71，3： | 1 |
| 16 | Long-term changes in summer phytoplankton communities of the open northern Baltic Sea显示文摘 | SANNA S MARIA L MAIJA H | 2007 | Estuarine Coastal and Shelf Science2007，71，： | 1 |
| 17 | Up- regulation of the phophatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatmentwith hCG and insulin显示文摘 | Maria H M Lima L l lian C Souza Luciana C Caperuto | 2006 | Journal of Endocrinology2006，190，4： | 1 |
| 18 | Influence of nitric oxide donors on the intrinsic fluorescence of Na:, K:-ATPase and effects on the membrane lipids显示文摘 | Maria L B Carlos F F Aida H V | 2005 | Nitric Oxide2005，13，： | 1 |
| 19 | Long-term changes in summer phytoplankton communities of the open northern Baltic Sea 显示文摘 | SANNA S MARIA L MAIJA H | 2006 | Estuafine Coastal and Shelf Science2006，71，34： | 1 |
| 20 | Side population in human lung cancer cell lines and tumors is enriched with stemlike cancer cells显示文摘 | Maria M H Alvin V N Stephen L | 2007 | Cancer Res2007，67，10： | 1 |
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