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| 1 | Efficacy and safety of endoscopic papillary balloon dilation for the removal of bile duct stones: Data from a “real-life” multicenter study on Dilation-Assisted Stone Extraction显示文摘AIM To report data on Dilation-Assisted Stone Extraction(DASE) use in clinical practice and its efficacy and safety trough three Italian referral centers for biliopancreatic diseases treatment. METHODS From January 2011 to December 2015 we collected data on 120 patients treated with DASE. Technical success was obtained when the endoscopist was able to place the balloon trough the papilla inflating the balloon until the final diameter for an adequate time(at least 30 s). Clinical success was obtained after complete stone removal(no remaining stones were visible at the cholangiogram).RESULTS Forty-nine male(40.8%) and 71 female(59%) were enrolled. The mean age was 67.8 years ± 15.7. The mean common bile duct(CBD) dilation was 19.2 mm± 3.9 and the mean size of stones 15.8 ± 2.9. DASE was applied as first approach in 38%(62% after initial failure of stones extraction). Technical and clinical success was of 91% and 87% respectively. In those in which DASE failed alternative treatment were adopted. After DASE 18% of patients experienced a complication(bleeding 9%, pancreatitis 8%, perforation 0.8%). At univariable analysis, elective endoscopic retrograde cholangiopancreatography(P = 0.031), DASE as first approach(P = 0.032), and cannulation of major papilla followed by guidewire insertion(P = 0.004) were related to low risk of complications. Pre-cut was related to an increased risk of complications(P = 0.01). CONCLUSION DASE allowed a higher first-session success rate and can be consider a valid alternative to endoscopic sphincterotomy not only for bigger CBD stones. | Roberto Di Mitri Filippo Mocciaro Socrate Pallio Giulia Maria Pecoraro Andrea Tortora Claudio Zulli Simona Attardo Attilio Maurano | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
| 2 | Hepatitis Bvirus-related hepatocarcinogenesis: Molecular oncogenic potential of clear or occult infections显示文摘 | Maria Stella De Mitri Romina Cassini Mauro Bernardi | 2010 | Eur J Cancer2010，46，12： | 1 |
| 3 | Covid-19 pneumonia:Timing of pneumomediastinum and pneumothorax in 11 patients显示文摘Purpose:As the pandemic continues,many complications,previously recognized as rare,are now being reported as more than frequent complications of Covid-19 pneumonia.Of those,pneumomediastinum and pneumothorax are gaining attention.Their mechanism of occurrence/trigger is not fully understood,but the timing at which they occur is unclear.Methods:This is a case series of 11 Covid-19 patients with pneumomediastinum;retrospectively,we shed light on some of the patients’characteristics,the role of mechanical ventilation,and the timing of pneumomediastinum after initiation of mechanical ventilation.Results:We found that despite following the lung-protective strategy and despite keeping a plateau pressure at an acceptable range,most of our patients had an acute event around the same timing of mechanical ventilation.Conclusions:The similar timing raises questions about other risk factors that remain unknown.Timing and steroids can contribute to the higher incidence of these complications. | Mostafa Al Turk Maria Mitri Kawthar Jarrah Joanna Abi Chebl Georges Juvelekian | 2021 | Discussion of Clinical Cases2021，8，2： | 0 |
| 4 | Rapid killer:Lung squamous cell cancer显示文摘Background:Lung cancer is one of the leading causes of death despite improvement in treatment modalities such as immunotherapy with chemotherapy and precise radiotherapy.NSCLC is a heterogeneous group of diseases that differs in cytology and includes adenocarcinoma,squamous cell carcinoma,bronchioloalveolar carcinoma,and poorly differentiated carcinoma.Usually,NSCLC,in contrast to SCLC,spreads locally,and the doubling time of squamous cell carcinoma is 133 days which classifies it as a relatively slow-growing tumor.Case presentation:We present the case of a 72-year-old male,recently diagnosed with squamous cell carcinoma in the right upper lobe along with secondary deposits.Few days after diagnosis,the patient had severe respiratory distress.This endobronchial tumor has increased significantly in size upon bronchoscopic visualization causing a complete obstruction of his right main bronchus and hypoxemic respiratory failure requiring intubation.Conclusion:To our knowledge,there are few reported cases where lung adenocarcinoma progressed rapidly over days.Squamous cell carcinoma usually takes 3 to 6 months to double in size,but in our case,the progression was very fast.In the last decade,it was confirmed that the doubling time of a tumor is an independent factor in the prognosis of lung cancer patients.On the other hand,further studies are needed to identify genes associated with rapid progression and a worse prognosis for lung squamous cell carcinoma.Hence,this aggressive tumor is a“rapid killer.” | Maria Mitri Samer F.Nehme | 2021 | Discussion of Clinical Cases2021，8，2： | 0 |
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