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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Urokinase plasminogen activator, uPA receptor and its inhibitor in vernal keratoconjunctivitis显示文摘 | ANDREA L PAOLA B MARIA T S | 2005 | Invest Ophthalm Vis Sci2005，46，： | 1 |
| 3 | MCM41 functionalized with ethylenediaminetriacetic acid for ion-exchange chromatography 显示文摘 | Maria C B Corrado S Anna M T | 2011 | Journal of Materials Chemistry2011，21，： | 1 |
| 4 | Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies显示文摘 | Maria G T Katerina L Demosthenes B | | 0，，01： | 1 |
| 5 | Analyzing a fLrm' s In- ternational Portfolio of Technological Knowledge: A Declarative Ontology-based OWL Approach for Patent Documents显示文摘 | Maria B E Manuel N Nuria H T | 2013 | Ad- vanced Engineering Informatics2013，27，3： | 1 |
| 6 | Aerobic Denitrifying Bacteria that Produce Low Levels of Nitrous Oxide显示文摘 | Naoki T Maria A B Catalan S | 2003 | Applied and Environemntal Microbiology2003，69，6： | 1 |
| 7 | The problem of assigning responsibility for greenhouse gas emissions 显示文摘 | Simone B Maria P F Enzo T | 2004 | Ecological Economics2004，，49： | 1 |
| 8 | Activators of peroxisome proliferator-activated receptor γhave depot-specific effect on human preadipocyte differentiation显示文摘 | MARIA A CARL T M JOHANNES B P | 1997 | J Clin Invest1997，100，12： | 1 |
| 9 | Trace Analysis of Seven Neonicotinoid Insecticides in Bee Pollen by Solid-liquid Extraction and Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry显示文摘 | KAREN P Y MARIA T M JOSE L B | 2014 | Food Analytical Methods2014，7，2： | 1 |
| 10 | Solid-state synthesis of ultrafine BaTiO3 power from nanocry-stalline BaCO3 and TiO2显示文摘 | Maria T B Marta B Vincenzo B | 2005 | Amer Ceram Soc2005，88，9： | 1 |
| 11 | Extraction of lignin from sugar cane bagasse and Pinus taeda wood chips using ethanol-water mixture and carbon dioxide at high pressures显示文摘 | DANIEL P MARIA T B LUIZ h F | 2005 | The Journal of Supercritical Fluids2005，36，1： | 1 |
| 12 | The role of apoptosis in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS) : an up-to-date cell-specific review 显示文摘 | Vasiliki G Eleftheria T Maria B | 2010 | Pathology Re- search and Practice2010，206，3： | 1 |
| 13 | Solid-state synthesis of ultrafine BaTiO3 power from nanocry-stalline BaCO3 and TiO2 显示文摘 | Maria T B Marta B Vincenzo B | 2005 | J Amer Ceram Soc2005，88，9： | 1 |
| 14 | Subcellular details of early events of differentiation induced by retinoic acid in human neuroblastoma cells detected by atomic force microscope显示文摘 | ANNALISA B MARIA T P GIAN P T | 1995 | Exp Cell Res1995，216，1： | 1 |
| 15 | Evolution of cellulose crystals during prehydrolysis and soda delignification of sugm: cane lignocelluloses 显示文摘 | Carlos D Maria T B George J M | 2011 | Cellulose2011，18，6： | 1 |
| 16 | 显示文摘 | Maria H Wu B H Kollmann T | 2014 | Advanced Functional Materials2014，24，21： | 1 |
| 17 | Acetate as a carbon source for hydrogen production by photosynthetic bacteria显示文摘 | MARIA J B JORGE M S R JOHANNES T | 2001 | J Biotechnol2001，85，1： | 1 |
| 18 | Solid-state synthesis of uhrafine BaTiO3 power from nanocry-stalline BaCO3 and TiO2 显示文摘 | Maria T B Marta B T Vincenzo B | 2005 | Amer Ceram Soc2005，88，9： | 1 |
| 19 | Protein degradation in C3 and C4 plants with particular reference to ribulose bisphosphate carboxylase and glycolate oxidase显示文摘 | MARIA G E RICARDO B F ARTUR R T | 1998 | Journal of Experimental Botany1998，49，： | 1 |
| 20 | Ferroelectric Properties of Dense Nanocrystalline BaTiO3 Ceramics 显示文摘 | Maria T B Buscaglia V Viviani M | 2004 | Nanotechnology2004，15，9： | 1 |
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