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| 1 | Computed tomography findings of pneumatosis and portomesenteric venous gas in acute bowel ischemia显示文摘AIM:To use more representative sample size to evaluate whether computed tomography(CT)scan evidence of the concomitant presence of pneumatosis and portomesenteric venous gas is a predictor of transmural bowel necrosis.METHODS:Data from 208 patients who were referred for a diagnosis of bowel ischemia were retrospectively reviewed.Only patients who underwent a surgical intervention following a diagnosis of bowel ischemia who also had a post-operative histological confirmation of such a diagnosis were included.Patients were split into two groups according to the presence of histological evidence of transmural bowel ischemia(case group)or partial bowel ischemia(control group).CT images were reviewed for findings of ischemia,including mural thickening,pneumatosis,bowel distension,portomesenteric venous gas and arterial or venous thrombi.RESULTS:A total of 248 subjects who underwent surgery for bowel ischemia were identified.Among the208 subjects enrolled in our study,transmural bowel necrosis was identified in 121 subjects(case group),and partial bowel necrosis was identified in 87 subjects(control group).Based on CT findings,including mural thickening,bowel distension,pneumatosis,pneumatosis plus portomesenteric venous gas and presence of thrombi or emboli,there were no significant differences between the case and control groups.The concomitant presence of pneumatosis and porto-mesenteric venous gas showed an odds ratio of 1.95(95%CI:0.491-7.775,P=0.342)for the presence of transmural necrosis.The presence of pneumatosis plus porto-mesenteric venous gas exhibited good specificity(83%)but low sensitivity(17%)in the identification of transmural bowel infarction.Accordingly,the positive and negative predictive values were 60% and 17%,respectively.CONCLUSION:Although pneumatosis plus porto-mesenteric venous gas is associated with bowel ischemia,we have demonstrated that their co-occurrence cannot be used as diagnostic signs of transmural necrosis. | Marco Milone Matteo Nicola Dario Di Minno Mario Musella Paola Maietta Vittorio Iaccarino Giovanni Barone Francesco Milone | 2013 | World Journal of Gastroenterology2013，19，39： | 15 |
| 2 | Role of colonoscopy in the diagnostic work-up of bowel endometriosis显示文摘AIM:To evaluate the accuracy of colonoscopy for the prediction of intestinal involvement in deep pelvic endometriosis.METHODS:This prospective observational study was performed between September 2011 and July 2014.Only women with both a clinical and imaging diagnosis of deep pelvic endometriosis were included.The study was approved by the local ethics committee and written informed consent was obtained in all cases.Both colonoscopy and laparoscopy were performed by expert surgeons with a high level of expertise with these techniques.Laparoscopy was performed within4 wk of colonoscopic examination.All hypothetical colonoscopy findings(eccentric wall thickening with or without surface nodularities and polypoid lesions with or without surface nodularities of endometriosis)were compared with laparoscopic and histological findings.We calculated the sensitivity,specificity,positive predictive value and negative predictive value for the presence of colonoscopic findings of intestinal endometriosis.RESULTS:A total of 174 consecutive women aged between 21-42 years with a diagnosis of deep pelvic endometriosis who underwent colonoscopy andsurgical intervention were included in our analysis.In 76 of the women(43.6%),intestinal endometrial implants were found at surgery and histopathological examination.Specifically,38 of the 76 lesions(50%)were characterized by the presence of serosal bowel nodules;28 of the 76 lesions(36.8%)reached the muscularis layer;8 of the 76 lesions(10.5%)reached the submucosa;and 2 of the 76 lesions(2.6%)reached the mucosa.Colonoscopic findings suggestive of intestinal endometriosis were detected in 7 of the174(4%)examinations.Colonoscopy failed to diagnose intestinal endometriosis in 70 of the 76 women(92.1%).A colonoscopic diagnosis of endometriosis was obtained in all cases of mucosal involvement,in 3of 8 cases(37.5%)of submucosal involvement,in no cases of muscularis layer involvement and in 1 of 38cases(2.6%)of serosa involvement.The sensitivity,specificity,positive predictive and negative predictive values of colonoscopy for the diagnosis of intestinal endometriosis were 7%,98%,85%and 58%,respectively.CONCLUSION:Being an invasive procedure,colonoscopy should not be routinely performed in the diagnostic work-up of bowel endometriosis. | Marco Milone Antonio Mollo Mario Musella Paola Maietta Loredana Maria Sosa Fernandez Olena Shatalova Alessandro Conforti Gianni Barone Giuseppe De Placido Francesco Milone | 2015 | World Journal of Gastroenterology2015，21，16： | 5 |
| 3 | Decrease of serum carnitine levels in patients with or without gastrointestinal cancer cachexia显示文摘瞄准:在消化机关与癌症在病人评估浆液肉毒碱的层次并且把他们与另外的癌症作比较以便提供新卓见进极度瘦弱的机制。方法:55 个恶病质病人与或没有胃肠的癌症在现在的学习被注册。他们经历了平淡的实验室调查,包括在浆液在场的肉毒碱的各种各样的形式的层次的检查(即,长链的酰肉毒碱,短链的酰肉毒碱,免费肉毒碱,和全部的肉毒碱) 。这些价值与 30 个健康控制题目在好营养的地位以及与那些在 60 个癌症病人发现的那些相比。结果:当没有胃肠的癌症,有胃肠的癌症的恶病质病人与恶病质病人相比时,差别是在免费肉毒碱的 -6.8 micromol/L (P <
0.005 ) ,在长链酰肉毒碱的 0.04 micromol/L (P <
0.05 ) ,在全部的肉毒碱的 8.7 micromol/L (P <
0.001 ) 。在恶病质病人与或没有胃肠的癌症,差别是在免费肉毒碱的 12.2 micromol/L ( P <
0.001 ),在短链酰肉毒碱的 4.60 micromol/L ( P <
0.001 ),并且在长链的酰肉毒碱的 0.60 微摩尔 /L ( P <
0.005 )并且在全部的肉毒碱的 17.4 micromol/L ( P <
0.001 )。在有胃肠的癌症和健康控制题目的恶病质病人,差别是在免费肉毒碱的 15.5 micromol/L ( P <
0.001 ),在短链的酰肉毒碱的 5.2 微摩尔 /L ( P <
0.001 ),在长链酰肉毒碱的 1.0 micromol/L ( P <
0.001 ),并且在全部的肉毒碱的 21.8 micromol/L ( P <
0.001 )。结论:在终端的肉毒碱的低浆液层次肿瘤的病人由于减少的饮食的吸入极大地被减少并且损害了这种物质的内长的合成。这些低浆液肉毒碱层次也在癌症病人贡献极度瘦弱的前进。 | Mariano Malaguarnera Corrado Risino Maria Pia Gargante Giovanni Oreste Gloria Barone Anna Veronica Tomasello Mario Costanzo Matteo Angelo Cannizzaro | 2006 | World Journal of Gastroenterology2006，12，28： | 3 |
| 4 | Disconnected pancreatic duct syndrome in severe acute pancreatitis: clinical and imaging characteristics and outcomes in a cohort of 31 cases显示文摘 | Mario Pelaez-Luna Santhi Swaroop Vege Bret T. Petersen Suresh T. Chari Jonathan E. Clain Michael J. Levy Randal K. Pearson Mark D. Topazian Michael B. Farnell Michael L. Kendrick Todd H. Baron | 2008 | Gastrointestinal Endoscopy2008，，1： | 2 |
| 5 | High mobility group box - 1 expression correlates with poor outcome in lunginjury patients 显示文摘 | Alessandra Bitto Mario Barone Polito F | 2010 | Pharmacological Research2010，61，2： | 1 |
| 6 | Spontaneous Pneumomediastinum: Experience in 18 Adult Patients显示文摘 | Baldassare Mondello Rosaria Pavia Paolo Ruggeri Mario Barone Pietro Barresi Maurizio Monaco | 2007 | Lung2007，，1： | 1 |
| 7 | Antigastric autoantibodies inHelicobacter pylori infection: role in gastric mucosal inflammation显示文摘 | D. Basso N. Gallo C. -F. Zambon M. Baron F. Navaglia E. Stockreiter F. Mario M. Rugge M. Plebani | 2000 | International Journal of Clinical & Laboratory Research2000，，4： | 1 |
| 8 | Hydradenitis suppurativa and inflammatory bowel disease: An unusual, but existing association显示文摘Inflammatory bowel disease(IBD) could be associated with several extra-intestinal manifestations(EIMs) involving musculoskeletal, hepatopancreatobiliary, ocular, renal, and pulmonary systems, as well as the skin. In the last years, hidradenitis suppurativa(HS) is acquiring an increasing interest. IBD, especially Crohn's disease(CD), is among the most reported associated diseases in HS patients. The aim of this paper is to give a brief overview of data showing a possible epidemiologic and pathogenetic association between IBD and HS. We performed a pooled-data analysis of four studies and pooled prevalence of HS in IBD patients was 12.8%, with a 95%CI of 11.7%-13.9%. HS was present in 17.3% of subjects with CD(95%CI: 15.5%-19.1%) and in 8.5% of UC patients(95%CI: 7.0%-9.9%). Some items, especially altered immune imbalance, are generally involved in IBD pathogenesis as well as invoked by HS. Smoking is one of the most relevant risk factors for both disorders, representing a predictor of their severity, despite, actually, there being a lack of studies analyzing a possible shared pathway. A role for inheritance in HS and CD pathogenesis has been supposed. Despite a genetic susceptibility having been demonstrated for both diseases, further studies are needed to investigate a genetic mutual route. Although the pathogenesis of IBD and HS is generally linked to alterations of the immune response, recent findings suggest a role for intestinal and skin microbiota, respectively. In detail, the frequent finding of Staphylococcus aureus and coagulase-negative staphylococci on HS cutaneous lesions suggests abacterial involvement in disease pathogenesis. Moreover, microflora varies in the different cutaneous regions of the body and, consequently, two different profiles of HS patients have been identified on these bases. On the other hand, it is well-known that intestinal microbiota may be considered as 'the explosive mixture' at the origin of IBD despite the exact relationship having not been completely clarified yet. A better comprehension of the role that some bacterial species play in the IBD pathogenesis may be essential to develop appropriate management strategies in the near future. A final point is represented by some similarities in the therapeutic management of HS and IBD, since they may be controlled by immunomodulatory drugs. In conclusion, an unregulated inflammation may cause the lesions typical of both HS and IBD, particularly when they coexist. However, this is still a largely unexplored field. | Mariabeatrice Principi Nicoletta Cassano Antonella Contaldo Andrea Iannone Giuseppe Losurdo Michele Barone Mario Mastrolonardo Gino Antonio Vena Enzo Ierardi Alfredo Di Leo | 2016 | World Journal of Gastroenterology2016，22，20： | 1 |
| 9 | A parative study of the synthesis of rcbutyl-oleate using a crude lipolytic extract of penicillum cordophilum in water restricted environments 显示文摘 | Alessandra M Baron Marialnez M Sarquis Mario Baigori | 2005 | Jourual of Molecular Catalysis B: Guzymatic2005，34，： | 1 |
| 10 | Carcinomatous Solitary Pulmontary Nodules:Evaluation of the Tumor-Bronchi Relationship with Thin-Section CT显示文摘 | Gaeta Michele Mario Barone | 1993 | Radiology1993，187，2： | 1 |
| 11 | Disconnected pancreatic duct syndrome in severe acute pancreatitis: clinical and imaging characteristics and outcomes in a cohort of 31 cases显示文摘 | Mario Pelaez-Luna Santhi Swaroop Vege Bret T. Petersen Suresh T. Chari Jonathan E. Clain Michael J. Levy Randal K. Pearson Mark D. Topazian Michael B. Farnell Michael L. Kendrick Todd H. Baron | 2008 | Gastrointestinal Endoscopy2008，，1： | 1 |
| 12 | Spontaneous Pneumomediastinum: Experience in 18 Adult Patients显示文摘 | Baldassare Mondello Rosaria Pavia Paolo Ruggeri Mario Barone Pietro Barresi Maurizio Monaco | 2007 | Lung2007，，1： | 1 |
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