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| 1 | The role of small vessel disease in development of Alzheimer's disease显示文摘Classically Alzheimer's disease and vascular dementia have been considered as two different entities,with their own clinical criteria,but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms.Cerebrovascular lesions,especially small vessel disease(lacunar infarcts,white matter hyperintensities and microbleeds),may magnify the effects of mild Alzheimer's disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia.'Vascular hypothesis' of Alzheimer's disease would open a window for new approaches and treatments. | Marta Grau-Slevin Adria Arboix John Gaffney Mark Slevin | 2010 | Neural Regeneration Research2010，5，4： | 4 |
| 2 | Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress显示文摘 | Dong Liu Sic L. Chan Nadja C. Souza-Pinto John R. Slevin Robert P. Wersto Ming Zhan Khadija Mustafa Rafael Cabo Mark P. Mattson | 2006 | NeuroMolecular Medicine2006，，： | 1 |
| 3 | Three-dimensional structure and survival of newly formed blood vessels after focal cerebral ischemia显示文摘 | Jerzy Krupinski Paul Stroemer Mark Slevin Eulalia Marti Pat Kumar Francisco Rubio | 2003 | NeuroReport2003，，8： | 1 |
| 4 | Monomeric C-reactive protein and Notch-3 co-operatively increase angiogenesis through PI3K signalling pathway显示文摘 | Emhamed Boras Mark Slevin M. Yvonne Alexander Ali Aljohi William Gilmore Jason Ashworth Jerzy Krupinski Lawrence A. Potempa Ibrahim Al Abdulkareem Adila Elobeid Sabine Matou-Nasri | 2014 | Cytokine2014，，2： | 1 |
| 5 | Induced pluripotent stem cells as a potential therapeutic source for corneal epithelial stem cells显示文摘Corneal blindness caused by limbal stem cell deficiency(LSCD) is one of the most common debilitating eye disorders. Thus far, the most effective treatment for LSCD is corneal transplantation, which is often hindered by the shortage of donors. Pluripotent stem cell technology including embryonic stem cells(ESCs) and induced pluripotent stem cells(iPSCs) have opened new avenues for treating this disease. iPSCs-derived corneal epithelial cells provide an autologous and unlimited source of cells for the treatment of LSCD. On the other hand, iPSCs of LSCD patients can be used for iPSCs-corneal disease model and new drug discovery. However, prior to clinical trial, the efficacy and safety of these cells in patients with LSCD should be proved. Here we focused on the current status of iPSCs-derived corneal epithelial cells used for cell therapy as well as for corneal disease modeling. The challenges and potential of iPSCs-derived corneal epithelial cells as a choice for clinical treatment in corneal disease were also discussed. | Jie Zhu Mark Slevin Bao-Qiang Guo Shou-Rong Zhu | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 1 |
| 6 | Potential of adipose derived stem cell preparations in neurological repair and regeneration显示文摘Stem cell therapy is a promising treatment for neurogenerative disease as well as inflammatory and immune mediated diseases.Decades of preclinical research has demonstrated stem cell ability to differentiate into multiple cell lineages and be utilised in regeneration and repair with their immunomodulatory and immunosuppressive properties.This work has provided the fundamental scientific knowledge needed to launch various clinical trials studying stem cell therapy in autoimmune disorders,stroke,and other tissue injury.Despite the early success many of these promising therapies are yet to breakthrough into clinical use.In this review,we highlight the recent developments in the use of stem cells as therapeutic agents for neurological conditions as well as their failures and how the clinical translation can be improved. | Laura Combes Xenia Sawkulycz Wen-Hui Fang Baoqiang Guo Mark Slevin | 2021 | Biophysics Reports2021，7，2： | 0 |
| 7 | Monomeric C-reactive protein:a link between chronic inflammation and neurodegeneration?显示文摘Pre-diabetic insulin resistance is associated with sub-clinical inflammation and concomitant increase in systemic C-reactive protein(CRP)levels.Type 2 diabetes mellitus(T2DM)patients register even higher chronic levels of inflammation,with excess circulating CRP originating from both typical hepatic synthesis,and also visceral white adipose tissue. | Nicoleta Arnaut Ylenia Pastorello Mark Slevin | 2024 | Neural Regeneration Research2024，19，8： | 0 |
| 8 | p38-MAPK and CDK5,signaling pathways in neuroinflammation:a potential therapeutic intervention in Alzheimer's disease?显示文摘Alzheimer’s disease(AD),the most common type of dementia,affects millions of people worldwide,putting a significant strain on healthcare infrastructure and societal resources.AD is characte rized by the build-up of amyloid-beta(Aβ)plaques and neurofibrillary to ngles containing hyperphosphorylated tau protein. | Vlad Ionut Viorel Ylenia Pastorello Nosherwan Bajwa Mark Slevin | 2024 | Neural Regeneration Research2024，19，8： | 0 |
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