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4篇 您的检索式：作者名="Markus Neumeier"

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		题名	作者	年代	出处	被引量
	1	Adiponectin,a key adipokine in obesity related liver diseases显示文摘Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western countries.Fatty liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin resistance.Hepatic steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of patients.Besides liver biopsy no diagnostic tools to identify patients with NASH are available,and no effective treatment has been established.Visceral obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage,insulin resistance,and progressive liver damage.Most of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver damage.Adiponectin is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or NASH.Adiponectin antagonizes excess lipid storage in the liver and protects from inflammation and fibrosis.This review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin.	Christa Buechler Josef Wanninger Markus Neumeier	2011	World Journal of Gastroenterology2011，17，23：	44
	2	Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis.	Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler	2006	World Journal of Gastroenterology2006，12，34：	4
	3	Systemic and hepatic vein galectin-3 are increased in patients with alcoholic liver cirrhosis and negatively correlate with liver function显示文摘	Josef Wanninger Johanna Weigert Reiner Wiest Sabrina Bauer Thomas Karrasch Stefan Farkas Marcus N. Scherer Roland Walter Thomas S. Weiss Claus Hellerbrand Markus Neumeier Andreas Sch?ffler Christa Buechler	2011	Cytokine2011，，3：	1
	4	Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis显示文摘	Roland Walter Josef Wanninger Sabrina Bauer Kristina Eisinger Markus Neumeier Thomas S. Weiss Thomas Amann Claus Hellerbrand Andreas Sch?ffler Jürgen Sch?lmerich Christa Buechler	2011	Experimental and Molecular Pathology2011，，3：	1

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