|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 视放射显微解剖与颞叶切除术后视野缺损显示文摘目的经过人尸脑内视放射纤维解剖,研究颞叶切除术后视野缺损的机制。方法人尸脑标本冷冻2周以上用自来水融冻后作为解剖用标本。用显微神经外科手术技术从大脑外侧面由浅入深进行脑内神经纤维的解剖,其中视放射解剖经过用立体照相技术予以纪录。结果视放射从外侧膝状体起始,途经颞叶和顶叶到达枕叶视觉皮质区。视放射中央束和部分后束纤维集中在侧脑室颞角后部的顶壁和房部前壁之内。成功解剖Meyer袢前界,Meyer袢最前方纤维部分向前伸入到杏仁核实质之内。侧裂点与脑岛后角位置相当,在侧脑室房部的外侧,并在外侧膝状体的上后方。结论向后越过Meyer袢前界的损伤可导致术后视野缺损。因视放射最前部纤维伸入到杏仁核实质之内,所以颞叶切除术后视野缺损并发症几乎不可完全避免。术后视野缺损程度与视放射纤维受损程度呈成正相关,轻者为象限性盲,重者为偏盲;视野缺损严重者具有黄斑视力和后束纤维的损伤。 | 李小勇 Carolina Martin Albert L. Rhoton 王忠诚 陈国强 左焕琮 | 2008 | 中华神经外科杂志2008，24，6： | 13 |
| 2 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 3 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 4 | Low-dose drug combination therapy: An alternative first-line approach to hypertension treatment显示文摘 | L.Michael Prisant Matthew R. Weir Vasilios Papademetriou Michael A. Weber Isaac A. Adegbile Demissie Alemayehu Martin P. Lefkowitz Albert A. Carr | 1995 | American Heart Journal1995，，2： | 2 |
| 5 | 治疗时间对氯胺酮抗抑郁作用影响的研究概况及未来展望显示文摘抑郁障碍是一种常见的严重精神疾病,具有高致残率和致死率,给社会和家庭造成严重负担。目前,近一半抑郁症患者无法得到有效的治疗。在临床实践中,可以广泛观察到氯胺酮具有明显缓解抑郁症状的作用,然而对其抗抑郁机理的研究尚不明确。笔者主要着眼于氯胺酮抗抑郁作用机理的相关研究进展,重点关注氯胺酮抗抑郁作用的短暂急性期和持续的延迟期机制的复杂相互作用的生物学基础,根据已有文献和前期研究结果提出可行的预设方案,旨在为氯胺酮抗抑郁作用的临床应用提供科学依据。 | 李申 李洁 田红军 Albert Leemon Walter Martin 禚传君 | 2018 | 中华诊断学电子杂志2018，6，3： | 2 |
| 6 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 7 | Functional Recovery After Acute Myocardial Infarction显示文摘 | Robin Nijveldt Aernout M. Beek Alexander Hirsch Martin G. Stoel Mark B.M. Hofman Victor A.W.M. Umans Paul R. Algra Jos W.R. Twisk Albert C. van Rossum | 2008 | Journal of the American College of Cardiology2008，，3： | 1 |
| 8 | Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells: Implications in Acute Myocardial Infarction显示文摘 | Roland Schmidt Andreas Bültmann Martin Ungerer Nader Joghetaei ?zgür Bülbül Sven Thieme Triantafyllos Chavakis Bryan P. Toole Meinrad Gawaz Albert Sch?mig Andreas E. May | 2006 | Circulation2006，，6： | 1 |
| 9 | Donor Site Morbidity After Anterior Iliac Crest Bone Harvest for Single-Level Anterior Cervical Discectomy and Fusion显示文摘 | Jeff S. Silber D. Greg Anderson Scott D. Daffner Brian T. Brislin J. Martin Leland Alan S. Hilibrand Alexander R. Vaccaro Todd J. Albert | 2003 | Spine2003，，： | 1 |
| 10 | Practical measurement of the residual stress in coatings显示文摘 | Anthony J Perry Albert Sue J Philip J Martin | 1996 | Surface and Coatings Technology1996，81，： | 1 |
| 11 | Diagnostic Value of Contrast-Enhanced Magnetic Resonance Imaging and Single-Photon Emission Computed Tomography for Detection of Myocardial Necrosis Early After Acute Myocardial Infarction显示文摘 | Tareq Ibrahim Hubertus P. Bülow Thomas Hackl Mira H?rnke Stephan G. Nekolla Martin Breuer Albert Sch?mig Markus Schwaiger | 2007 | Journal of the American College of Cardiology2007，，2： | 1 |
| 12 | Pierson syndrome in an adolescent girl with nephrotic range proteinuria but a normal GFR显示文摘 | Anja Lehnhardt Albert Lama Kerstin Amann Verena Matejas Martin Zenker Markus Kemper | 2012 | Pediatric Nephrology2012，，5： | 1 |
| 13 | Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model显示文摘Background:In vivo diffusion tensor imaging(DTI)of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis(ALS).Methods:Ten mice with TDP-43^(G298S) overexpression under control of the Thy1.2 promoter and 10 wild type(wt)underwent longitudinal DTI scans at 11.7 T,including one baseline and one follow-up scan with an interval of about 5months.Whole brain-based spatial statistics(WBSS)of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43^(G298S) mice compared to wt at the cohort level.Results were supplemented by tractwise fractional anisotropy statistics(TFAS)and histological evaluation of motor cortex for signs of neuronal loss.Results:Alterations at the cohort level in TDP-43^(G298S) mice were observed cross-sectionally and longitudinally in motor areas M1/M2 and in transcallosal fibers but not in the corticospinal tract.Neuronal loss in layer V of motor cortex was detected in TDP-43^(G298S) at the later(but not at the earlier)timepoint compared to wt.Conclusion:DTI mapping of TDP-43^(G298S) mice demonstrated progression in motor areas M1/M2.WBSS and TFAS are useful techniques to localize TDP-43^(G298S) associated alterations over time in this ALS mouse model,as a biological marker. | Hans-Peter Müller David Brenner Francesco Roselli Diana Wiesner Alireza Abaei Martin Gorges Karin M.Danzer Albert C.Ludolph William Tsao Philip C.Wong Volker Rasche Jochen H.Weishaupt Jan Kassubek | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 14 | PillCamColon2 after incomplete colonoscopy-A prospective multicenter study显示文摘AIM To evaluate the ability of PillCamColon2 to visualize colonic segments missed by incomplete optical colonoscopy(OC) and to assess the diagnostic yield.METHODS This prospective multicentre study included 81 patients from nine centres who underwent second-generation colon capsule endoscopy(CCE) following incomplete OC performed by an experienced gastroenterologist(> 1000 colonoscopies). Patients with stenosis were excluded. According to patient preferences, CCE was performed the following day(protocol A) after staying on clear liquids and 0.75 L Moviprep in the morning or within 30 d after new split-dose Moviprep(protocol B). Boosts consisted of 0.75 L and 0.25 L Moviprep, and phospho-soda was given as a rescue if the capsule was not excreted after seven hours.RESULTS Seventy-four patients were analysed(51% of them in group A; 49% in group B). Bowel cleansing was adequate in 67% of cases, and CCE could visualize colonic segments missed by incomplete colonoscopy in 90% of patients under protocol A and 97% of patients under protocol B(P = 0.35, n.s.). Significant polyps including adenocarcinoma were detected in 24% of cases. Detection rates for all polyps and significant polyps per patient were similar in both protocols. Polyps were found predominantly in the right colon(86%) in segments that were not reached by OC. Extracolonic findings-such as reflux esophagitis, suspected Barrett esophagus, upper GI-bleeding, gastric polyps, gastric erosions and angiectasia-were detected in eight patients. Pill Cam Colon2 capsule was retained in the ileum of one patient(1.4%) without symptoms and removed during an uneventful resection for unknown Crohn's disease that was diagnosed as the cause of anemia, which was the indication for colonoscopy. CCE was well tolerated. One patient suffered from selflimiting vomiting after consuming the phospho-soda.CONCLUSION Second-generation CCE using a low-volume preparation is useful after incomplete OC, and it allows for the detection of additional relevant findings, but cleansing efficiency could be improved. | Peter Baltes Marc Bota Jorg Albert Michael Philipper Hans-Georg Horster Friedrich Hagenmüller Ingo Steinbrück Ralf Jakobs Matthias Bechtler Dirk Hartmann Horst Neuhaus Jean-Pierre Charton Rupert Mayershofer Horst Hohn Thomas Rosch Stefan Groth Tanja Nowak Peter Wohlmuth Martin Keuchel | 2018 | World Journal of Gastroenterology2018，24，31： | 1 |
| 15 | Microfabrication of Oxidation-Sharpened Silicon Tips on Silicon Nitride Cantilevers for Atomic Force Microscopy 显示文摘 | Albert Folch Mark S Wrighton and Martin A Schmidt | 1997 | Journal of Microelectromechanical Systems1997，6，4： | 1 |
| 16 | 查看详情显示文摘 | Dai Y Hartandi K Ji Z Ji Z. Ahmed A. Albert D. Bauch J. Bouska J. Bousquet P. Cunha G. Glaser K. Harris C. Hickman D. Guo J. Li J. Marcotte P. Marsh K. Moskey M. Martin R. Olson A. Osterling D. Pease L. Soni N. Stewart K. Stoll V. Tapang P. Reuter D. D | | 0，，： | 1 |
| 17 | Predicting Outcome of Pulmonary Valve Replacement in Adult Tetralogy of Fallot Patients显示文摘 | Ivo R. Henkens Alexander van Straten Martin J. Schalij Mark G. Hazekamp Albert de Roos Ernst E. van der Wall Hubert W. Vliegen | 2007 | The Annals of Thoracic Surgery2007，，3： | 1 |
| 18 | A Simple test of visual neglect显示文摘 | Martin L Albert MD | 1973 | Neurology1973，23，： | 1 |
| 19 | Risk of esophageal variceal bleeding based on endoscopic ultrasound evaluation of the sum of esophageal variceal cross-sectional surface area显示文摘 | Larry Miller Felice L Banson Khalid Bazir Anapurna Korimilli J.i-Bin Liu Richa Dewan Michael Wolfson Kashyap V Panganamamula Jose Carrasquillo Jonathan Schwartz Albert E Chaker Martin Black | 2003 | The American Journal of Gastroenterology2003，，2： | 1 |
| 20 | A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation显示文摘 | Colleen T. O’Loughlin Laura C. Miller Albert Siryaporn Knut Drescher Martin F. Semmelhack Bonnie L. Bassler | 2013 | Proceedings of the National Academy of Sciences2013，，44： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员